دورية أكاديمية
mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates.
| العنوان: | mRNA-1273 protects against SARS-CoV-2 beta infection in nonhuman primates. |
|---|---|
| المؤلفون: | Corbett KS; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA., Werner AP; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Connell SO; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Gagne M; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lai L; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA, USA., Moliva JI; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Flynn B; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Choi A; Moderna, Cambridge, MA, USA., Koch M; Moderna, Cambridge, MA, USA., Foulds KE; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Andrew SF; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Flebbe DR; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Lamb E; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Nurmukhambetova ST; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Provost SJ; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Bock KW; Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Minai M; Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Nagata BM; Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Ry AV; Bioqual, Rockville, MD, USA., Flinchbaugh Z; Bioqual, Rockville, MD, USA., Johnston TS; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Mokhtari EB; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Mudvari P; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Henry AR; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Laboune F; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Chang B; Bioqual, Rockville, MD, USA., Porto M; Bioqual, Rockville, MD, USA., Wear J; Bioqual, Rockville, MD, USA., Alvarado GS; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Boyoglu-Barnum S; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Todd JM; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Bart B; Bioqual, Rockville, MD, USA., Cook A; Bioqual, Rockville, MD, USA., Dodson A; Bioqual, Rockville, MD, USA., Pessaint L; Bioqual, Rockville, MD, USA., Steingrebe K; Bioqual, Rockville, MD, USA., Elbashir S; Moderna, Cambridge, MA, USA., Sriparna M; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Pekosz A; Department of Microbiology and Immunology, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, MD, USA., Andersen H; Bioqual, Rockville, MD, USA., Wu K; Moderna, Cambridge, MA, USA., Edwards DK; Moderna, Cambridge, MA, USA., Kar S; Bioqual, Rockville, MD, USA., Lewis MG; Bioqual, Rockville, MD, USA., Boritz E; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Moore IN; Infectious Disease Pathogenesis Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Carfi A; Moderna, Cambridge, MA, USA., Suthar MS; Center for Childhood Infections and Vaccines of Children's Healthcare of Atlanta, Department of Pediatrics, Department of Microbiology and Immunology, Emory Vaccine Center, Emory University, Atlanta, GA, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, USA., McDermott A; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Roederer M; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Nason MC; Biostatistics Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Baltimore, MD, USA., Sullivan NJ; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Douek DC; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA., Graham BS; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. bgraham@nih.gov., Seder RA; Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. rseder@mail.nih.gov. |
| المصدر: | Nature immunology [Nat Immunol] 2021 Oct; Vol. 22 (10), pp. 1306-1315. Date of Electronic Publication: 2021 Aug 20. |
| نوع المنشور: | Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature America Inc Country of Publication: United States NLM ID: 100941354 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1529-2916 (Electronic) Linking ISSN: 15292908 NLM ISO Abbreviation: Nat Immunol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Nature America Inc. c2000- |
| مواضيع طبية MeSH: | COVID-19/*immunology , COVID-19 Vaccines/*immunology , Primates/*immunology , SARS-CoV-2/*immunology, 2019-nCoV Vaccine mRNA-1273 ; Animals ; Antibodies, Neutralizing/immunology ; Antibodies, Viral/immunology ; COVID-19/virology ; Cell Line ; Chlorocebus aethiops ; Female ; Humans ; Macaca mulatta ; Male ; Mesocricetus ; Primates/virology ; RNA, Viral/immunology ; Spike Glycoprotein, Coronavirus/immunology ; Vaccination/methods ; Vero Cells ; Viral Load/methods |
| مستخلص: | B.1.351 is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant most resistant to antibody neutralization. We demonstrate how the dose and number of immunizations influence protection. Nonhuman primates received two doses of 30 or 100 µg of Moderna's mRNA-1273 vaccine, a single immunization of 30 µg, or no vaccine. Two doses of 100 µg of mRNA-1273 induced 50% inhibitory reciprocal serum dilution neutralizing antibody titers against live SARS-CoV-2 p.Asp614Gly and B.1.351 of 3,300 and 240, respectively. Higher neutralizing responses against B.1.617.2 were also observed after two doses compared to a single dose. After challenge with B.1.351, there was ~4- to 5-log (© 2021. This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.) |
| التعليقات: | Comment in: Nat Immunol. 2021 Oct;22(10):1201-1203. (PMID: 34531563) |
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| معلومات مُعتمدة: | HHSN272201400004C United States AI NIAID NIH HHS; Z01 AI005030 United States ImNIH Intramural NIH HHS |
| المشرفين على المادة: | 0 (Antibodies, Neutralizing) 0 (Antibodies, Viral) 0 (COVID-19 Vaccines) 0 (RNA, Viral) 0 (Spike Glycoprotein, Coronavirus) EPK39PL4R4 (2019-nCoV Vaccine mRNA-1273) |
| تواريخ الأحداث: | Date Created: 20210821 Date Completed: 20211012 Latest Revision: 20231107 |
| رمز التحديث: | 20231107 |
| مُعرف محوري في PubMed: | PMC8488000 |
| DOI: | 10.1038/s41590-021-01021-0 |
| PMID: | 34417590 |
| قاعدة البيانات: | MEDLINE |
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