دورية أكاديمية
Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma.
| العنوان: | Arginase-1 and P-glycoprotein are downregulated in canine hepatocellular carcinoma. |
|---|---|
| المؤلفون: | Kim SH; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Seung BJ; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Cho SH; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Lim HY; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Bae MK; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea., Sur JH; Department of Veterinary Pathology, Small Animal Diagnostic Center, College of Veterinary Medicine, Konkuk University, Seoul 05029, Korea. jsur@konkuk.ac.kr. |
| المصدر: | Journal of veterinary science [J Vet Sci] 2021 Sep; Vol. 22 (5), pp. e61. Date of Electronic Publication: 2021 Jul 12. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society of Veterinary Science Country of Publication: Korea (South) NLM ID: 100964185 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1976-555X (Electronic) Linking ISSN: 1229845X NLM ISO Abbreviation: J Vet Sci Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean Society of Veterinary Science, 2000- |
| مواضيع طبية MeSH: | Down-Regulation*, ATP Binding Cassette Transporter, Subfamily B, Member 1/*genetics , Arginase/*genetics , Carcinoma, Hepatocellular/*veterinary , Dog Diseases/*metabolism, ATP Binding Cassette Transporter, Subfamily B, Member 1/metabolism ; Animals ; Arginase/metabolism ; Carcinoma, Hepatocellular/etiology ; Carcinoma, Hepatocellular/metabolism ; Dog Diseases/etiology ; Dogs |
| مستخلص: | Background: Hepatocellular carcinoma is the most common primary hepatic malignancy in humans and dogs. Several differentially expressed molecules have been studied and reported in human hepatocellular carcinoma and non-neoplastic liver lesions. However, studies on the features of canine hepatocellular carcinoma are limited, especially related to the differential characteristics of neoplastic and non-neoplastic lesions. Objectives: The study's objective was 1) to examine and evaluate the expression of arginase-1, P-glycoprotein, and cytokeratin 19 in canine liver tissues and 2) to investigate the differential features of hepatocellular carcinomas, liver tissue with non-neoplastic lesions, and paracancerous liver tissues in dogs. Methods: The expression levels of three markers underwent immunohistochemical analysis in 40 non-neoplastic liver tissues, 32 hepatocellular carcinoma tissues, and 11 paracancerous liver tissues. Scoring of each marker was performed semi-quantitatively. Results: Arginase-1 and P-glycoprotein were significantly downregulated in hepatocellular carcinoma, compared with hepatic tissues with non-neoplastic diseases ( p < 0.001). Expression levels of arginase-1 and P-glycoprotein were also significantly lower in hepatocellular carcinoma than in paracancerous liver tissues (arginase-1, p = 0.0195; P-glycoprotein, p = 0.047). Few cytokeratin 19-positive hepatocytes were detected and only in one hepatocellular carcinoma and one cirrhotic liver sample. Conclusions: The results of this study suggest that downregulation of arginase-1 and P-glycoprotein is a feature of canine hepatocellular carcinoma; thus, those markers are potential candidates for use in differentiating hepatocellular carcinomas from non-neoplastic liver lesions in dogs. Competing Interests: The authors declare no conflicts of interest. (© 2021 The Korean Society of Veterinary Science.) |
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| معلومات مُعتمدة: | 2016M3A9B6903437 Korea NRF National Research Foundation of Korea |
| فهرسة مساهمة: | Keywords: Arginase; P-glycoprotein; dog; hepatocellular carcinoma; liver |
| المشرفين على المادة: | 0 (ATP Binding Cassette Transporter, Subfamily B, Member 1) EC 3.5.3.1 (Arginase) |
| تواريخ الأحداث: | Date Created: 20210823 Date Completed: 20211115 Latest Revision: 20211115 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8460467 |
| DOI: | 10.4142/jvs.2021.22.e61 |
| PMID: | 34423599 |
| قاعدة البيانات: | MEDLINE |
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