دورية أكاديمية
Impact of eugenol on in vivo model of 6-hydroxydopamine-induced oxidative stress.
| العنوان: | Impact of eugenol on in vivo model of 6-hydroxydopamine-induced oxidative stress. |
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| المؤلفون: | Pontes NHL; Biotechnology Core of Sobral, State University of Vale do Acaraú - UVA, Sobral, Brazil.; Faculty of Medicine, Federal University of Ceará - UFC, Sobral, Brazil., Reis TDSD; Faculty of Medicine, Federal University of Ceará - UFC, Sobral, Brazil., Vasconcelos CFM; Biotechnology Core of Sobral, State University of Vale do Acaraú - UVA, Sobral, Brazil.; Faculty of Medicine, Federal University of Ceará - UFC, Sobral, Brazil., Aragão PTTD; Biotechnology Core of Sobral, State University of Vale do Acaraú - UVA, Sobral, Brazil.; Faculty of Medicine, Federal University of Ceará - UFC, Sobral, Brazil., Souza RB; Department of Biochemistry and Molecular Biology, Federal University of Ceará - UFC, Fortaleza, Brazil., Catunda Junior FEA; Centre of Exact, Natural and Technological Sciences (CCENT), State University of the Tocantina Region of Maranhão - UEMASUL, Imperatriz, Brazil., Aguiar LMV; Faculty of Medicine, Federal University of Ceará - UFC, Sobral, Brazil., Cunha RMSD; Biotechnology Core of Sobral, State University of Vale do Acaraú - UVA, Sobral, Brazil. |
| المصدر: | Free radical research [Free Radic Res] 2021 May; Vol. 55 (5), pp. 556-568. Date of Electronic Publication: 2021 Sep 01. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Informa Healthcare Country of Publication: England NLM ID: 9423872 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1029-2470 (Electronic) Linking ISSN: 10292470 NLM ISO Abbreviation: Free Radic Res Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : Informa Healthcare Original Publication: Yverdon, Switzerland : New York, NY : Harwood Academic ; distributed by STBS Ltd., c1994- |
| مواضيع طبية MeSH: | Eugenol*/pharmacology , Neuroprotective Agents*/pharmacology, Animals ; Antioxidants/pharmacology ; Oxidative Stress ; Oxidopamine/toxicity ; Rats |
| مستخلص: | Oxidative stress is involved in many pathological disturbs, such as neurodegenerative disorders. Eugenol (Eug) is a phenolic compound with antioxidant and neuroprotective activities. Then, this study was conducted to investigate the potential neuroprotective effects of Eug on oxidative stress model induced by 6-hydroxydopamine (6-OHDA) in rats. First, the in vivo oxidative stress model was performed by intrastriatal injection (int.) of 6-OHDA (21 µg), followed by the treatment of Eug (0.1, 1, and 10 mg/kg/7 d) per os (p.o.). On the 7 d, behavioral tests were performed. On the 8 d, all the animals were euthanasied and their cerebral areas were excised for neurochemical and transcriptional analyses. The results showed that the treatment with Eug promoted neuroprotective effects on in vivo through reducing of oxidative stress and modulation of genes related to antioxidant activity. Furthermore, animals treated with Eug demonstrated returning of behavioral performance and body weight gain to normal conditions. Thus, this study reports the neuroprotective effects of Eug against oxidative stress induced by 6-OHDA in rats. |
| فهرسة مساهمة: | Keywords: 6-hydroxydopamine; Parkinson’s disease; Reactive oxygen species (ROS); antioxidant potential; lipid peroxidation; nitrosative stress |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Neuroprotective Agents) 3T8H1794QW (Eugenol) 8HW4YBZ748 (Oxidopamine) |
| تواريخ الأحداث: | Date Created: 20210823 Date Completed: 20220211 Latest Revision: 20220211 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1080/10715762.2021.1971662 |
| PMID: | 34424800 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1029-2470 |
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| DOI: | 10.1080/10715762.2021.1971662 |