دورية أكاديمية
The role of circulating miRNAs and CA19-9 in pancreatic cancer diagnosis.
| العنوان: | The role of circulating miRNAs and CA19-9 in pancreatic cancer diagnosis. |
|---|---|
| المؤلفون: | Vieira NF; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Serafini LN; Department of Pathology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Novais PC; Postgraduate Program in Structural and Functional Interactions in Rehabilitation, University of Marilia, Marília, Brazil., Neto FSL; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Cirino MLA; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Kemp R; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Ardengh JC; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; Clinical Hospital of the Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Saggioro FP; Department of Pathology, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; Clinical Hospital of the Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Gaspar AF; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; Clinical Hospital of the Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Sankarankutty AK; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Júnior JRL; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.; Clinical Hospital of the Medical School of Ribeirão Preto, University of São Paulo, São Paulo, Brazil., Tirapelli DPDC; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil., Dos Santos JS; Department of Surgery and Anatomy, Medical School of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. |
| المصدر: | Oncotarget [Oncotarget] 2021 Aug 17; Vol. 12 (17), pp. 1638-1650. Date of Electronic Publication: 2021 Aug 17 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Impact Journals Country of Publication: United States NLM ID: 101532965 Publication Model: eCollection Cited Medium: Internet ISSN: 1949-2553 (Electronic) Linking ISSN: 19492553 NLM ISO Abbreviation: Oncotarget Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Albany, N.Y. : Impact Journals |
| مستخلص: | Diagnosis and treatment of pancreatic ductal adenocarcinoma (PA) remains a challenge in clinical practice. The aim of this study was to assess the role of microRNAs (miRNAs-21, -23a, -100, -107, -181c, -210) in plasma and tissue as possible biomarkers in the diagnosis of PA. Samples of plasma (PAp-n = 13), pancreatic tumors (PAt-n = 18), peritumoral regions (PPT-n = 9) were collected from patients during the surgical procedure. The control group consisted of samples from patients submitted to pancreatic surgery for trauma or cadaveric organs (PC-n = 7) and healthy volunteers donated blood (PCp-n = 6). The expression profile of microRNAs was measured in all groups using RT-PCR, serum CA19-9 levels were determined in PA and PC. In tissue samples, there was a difference in the expression of miRNAs-21, -210 ( p < 0.05) across the PAt, PC and PPT groups. The PAp showed overexpression of miRNAs-181c, -210 ( p < 0.05) when compared to PCp. The combination of miRNAs-21, -210 tissue expression and serum CA19-9 showed 100% accuracy in the diagnosis of PA, as well as miR-181c expression in the plasma (PApxPCp). The expression of microRNAs in plasma proved to be a promising tool for a noninvasive detection test for PA, as well as further studies will evaluate the utility of microRNAs expression as biomarkers for prognostic and response to therapy in PA. Competing Interests: CONFLICTS OF INTEREST The authors declare that there was no conflicts of interest that could be perceived to impair the impartiality of the research reported. (Copyright: © 2021 Vieira et al.) |
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| فهرسة مساهمة: | Keywords: CA19-9; biomarkers; cancer recurrence; microRNA; pancreatic cancer |
| تواريخ الأحداث: | Date Created: 20210826 Latest Revision: 20210827 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8378767 |
| DOI: | 10.18632/oncotarget.28038 |
| PMID: | 34434493 |
| قاعدة البيانات: | MEDLINE |
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