دورية أكاديمية
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Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry.

التفاصيل البيبلوغرافية
العنوان: Evaluation of the Free Radical Scavenging Activities of Ellagic Acid and Ellagic Acid Peracetate by EPR Spectrometry.
المؤلفون: Kumar A; Department of Chemistry, SRM University, Delhi-NCR, Haryana, 39, RGEC, Sonepat 131 029, India.; Department of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi 110 007, India., Kaushik P; Department of Chemistry, SRM University, Delhi-NCR, Haryana, 39, RGEC, Sonepat 131 029, India., Incerpi S; Department of Sciences, University of Rome 'Roma Tre', 00146 Rome, Italy., Pedersen JZ; Department of Biology, University of Rome 'Tor Vergata', Via della Ricerca, Scientifica 1, 00133 Rome, Italy., Goel S; Department of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi 110 007, India., Prasad AK; Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India., Rohil V; Department of Biochemistry, V. P. Chest Institute, University of Delhi, Delhi 110 007, India., Parmar VS; Bioorganic Laboratory, Department of Chemistry, University of Delhi, Delhi 110 007, India.; Department of Chemistry and Environmental Science, Medgar Evers College, The City University of New York, 1638 Bedford Avenue, Brooklyn, NY 11225, USA., Saso L; Department of Physiology and Pharmacology 'Vittorio Erspamer', Sapienza University, P. le. Aldo Moro 5, 00185 Rome, Italy., Len C; Institute of Chemistry for Life and Health Sciences, Chimie ParisTech, PSL Research University, CNRS, UMR8060, 11 rue Pierre et Marie Curie, F-75005 Paris, France.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Aug 08; Vol. 26 (16). Date of Electronic Publication: 2021 Aug 08.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Ellagic Acid*/pharmacology , Ellagic Acid*/chemistry , Ellagic Acid*/metabolism , Lipid Peroxidation*/drug effects , Free Radical Scavengers*/chemistry , Free Radical Scavengers*/pharmacology, Animals ; Rats ; Electron Spin Resonance Spectroscopy/methods ; Reactive Oxygen Species/metabolism ; Microsomes, Liver/metabolism ; Cell Line ; Myoblasts/metabolism ; Myoblasts/drug effects ; Kinetics
مستخلص: The purpose of this study was to examine the free radical scavenging and antioxidant activities of ellagic acid (EA) and ellagic acid peracetate (EAPA) by measuring their reactions with the radicals, 2,2-diphenyl-1-picrylhydrazyl and galvinoxyl using EPR spectroscopy. We have also evaluated the influence of EA and EAPA on the ROS production in L-6 myoblasts and rat liver microsomal lipid peroxidation catalyzed by NADPH. The results obtained clearly indicated that EA has tremendous ability to scavenge free radicals, even at concentration of 1 µM. Interestingly even in the absence of esterase, EAPA, the acetylated product of EA, was also found to be a good scavenger but at a relatively slower rate. Kinetic studies revealed that both EA and EAPA have ability to scavenge free radicals at the concentrations of 1 µM over extended periods of time. In cellular systems, EA and EAPA were found to have similar potentials for the inhibition of ROS production in L-6 myoblasts and NADPH-dependent catalyzed microsomal lipid peroxidation.
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فهرسة مساهمة: Keywords: L-6 myoblasts; cytotoxicity; electron paramagnetic resonance; ellagic acid; ellagic acid peracetate; free radical
المشرفين على المادة: 19YRN3ZS9P (Ellagic Acid)
0 (Free Radical Scavengers)
0 (Reactive Oxygen Species)
تواريخ الأحداث: Date Created: 20210827 Date Completed: 20240724 Latest Revision: 20240724
رمز التحديث: 20240726
مُعرف محوري في PubMed: PMC8399592
DOI: 10.3390/molecules26164800
PMID: 34443388
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26164800