دورية أكاديمية
أعرض في EDS

Frailty and health related quality of life three months after non-metastatic colorectal cancer diagnosis in older patients: A multi-centre prospective observational study.

التفاصيل البيبلوغرافية
العنوان: Frailty and health related quality of life three months after non-metastatic colorectal cancer diagnosis in older patients: A multi-centre prospective observational study.
المؤلفون: van der Vlies E; Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, the Netherlands., Vernooij LM; Department of Anesthesiology and Intensive Care, St. Antonius Hospital, Nieuwegein, the Netherlands; Department of Anesthesiology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands., Hamaker ME; Department of Geriatric Medicine, Diakonessenhuis, Utrecht, the Netherlands., van der Velden AMT; Department of Medical Oncology, Tergooi Hospital, Hilversum, the Netherlands., Smits M; Department of Gastroenterology and Hepatology, Tergooi Hospital, Hilversum, the Netherlands., Intven MPW; Department of Radiotherapy, University Medical Center Utrecht, the Netherlands., van Dodewaard JM; Department of Internal Medicine, Meander Medical Center, the Netherlands., Takkenberg M; Department of Surgery, Rivierenland Ziekenhuis, Tiel, the Netherlands., Vink GR; Department of Research and Development, Netherlands Comprehensive Cancer Organisation (IKNL), Utrecht, Netherlands; Department of Medical Oncology, University Medical Centre Utrecht, Utrecht University, Utrecht, the Netherlands., Smits AB; Department of Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands., Bos WJW; Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, the Netherlands; Department of Internal Medicine, Leiden University Medical Center, the Netherlands., van Dongen EPA; Department of Anesthesiology and Intensive Care, St. Antonius Hospital, Nieuwegein, the Netherlands., Los M; Department of Internal Medicine, St. Antonius Hospital, Nieuwegein, the Netherlands., Noordzij PG; Department of Anesthesiology and Intensive Care, St. Antonius Hospital, Nieuwegein, the Netherlands. Electronic address: p.noordzij@antoniusziekenhuis.nl.
المصدر: Journal of geriatric oncology [J Geriatr Oncol] 2022 Jan; Vol. 13 (1), pp. 74-81. Date of Electronic Publication: 2021 Aug 24.
نوع المنشور: Journal Article; Multicenter Study; Observational Study; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101534770 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-4076 (Electronic) Linking ISSN: 18794068 NLM ISO Abbreviation: J Geriatr Oncol Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Amsterdam : Elsevier
مواضيع طبية MeSH: Colorectal Neoplasms*/surgery , Frailty*/diagnosis , Frailty*/epidemiology, Aged ; Cohort Studies ; Humans ; Quality of Life ; Surveys and Questionnaires
مستخلص: Background: Health related quality of life (HRQL) is an important outcome measure in geriatric oncology. Surgery is the main treatment for colorectal cancer (CRC) but has been associated with a loss of HRQL in older patients. This study aimed to identify determinants for a decreased HRQL at three months after CRC diagnosis.
Method: This multi-centre observational cohort study (NCT04443816) included 273 patients aged ≥70 years diagnosed with non-metastatic CRC. A multi-domain frailty screening was performed in each patient. A decreased HRQL was defined as a mean difference ≥ 10 on the EORTC QLQ-C30 questionnaire between baseline and three months after CRC diagnosis. Determinants of a decreased HRQL were analysed using multivariable logistic regression.
Results: A decrease in HRQL occurred in 63 patients (23.1%). Non-surgical patients had the highest risk of decreased HRQL three months after diagnosis (adjusted odds ratio (OR) 6.4 (95% confidence interval (CI) 2.0-19.8)). The Charlson Comorbidity Index (CCI) (aOR 2.3 (95% (CI) 1.2-4.2)), the American Association of Anesthesiologists class (aOR 2.6 (95%CI 1.4-4.9)), impaired daily functioning (aOR 2.7 (95%CI 1.3-5.6)) and dependent living (aOR 1.9 (95%CI 1.1-4.5)) were associated with a decreased HRQL, mainly caused by non-surgical patients. In surgical patients, a major postoperative complication was a strong determinant of decreased HRQL and was associated with preoperative comorbidity and cognitive impairment (aOR 4.0 (95%CI 1.9-8.8)).
Conclusion: Frailty characteristics are highly prevalent in older patients at time of CRC diagnosis but not strongly associated with a decreased HRQL after three months. Non-surgical patients and patients with major postoperative complications had the highest risk of decreased HRQL. Registered at clinicaltrials.gov trial number: NCT04443816.
Competing Interests: Declaration of Competing Interest The authors have declared no conflicts of interest.
(Copyright © 2021 Elsevier Ltd. All rights reserved.)
فهرسة مساهمة: Keywords: Colorectal cancer; Frailty; Health related quality of life; Older patients
سلسلة جزيئية: ClinicalTrials.gov NCT04443816
تواريخ الأحداث: Date Created: 20210827 Date Completed: 20220228 Latest Revision: 20220228
رمز التحديث: 20240829
DOI: 10.1016/j.jgo.2021.08.005
PMID: 34446378
قاعدة البيانات: MEDLINE
الوصف
تدمد:1879-4076
DOI:10.1016/j.jgo.2021.08.005