دورية أكاديمية
Collagen XI Alpha 1 (COL11A1) Expression in the Tumor Microenvironment Drives Neuroblastoma Dissemination.
| العنوان: | Collagen XI Alpha 1 (COL11A1) Expression in the Tumor Microenvironment Drives Neuroblastoma Dissemination. |
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| المؤلفون: | Truong DQ; City Children's Hospital, Ho Chi Minh City, Vietnam., Ho BT; Department of Paediatric Surgery, Faculty of Medicine, University of medicine and pharmacy at Hochiminh city, Vietnam.; Children Hospital 2, Ho Chi Minh City, Vietnam., Chau GC; School of Medicine, Sungkyunkwan University, Suwon, Korea., Truong DK; Department of Paediatric Surgery, Faculty of Medicine, University of medicine and pharmacy at Hochiminh city, Vietnam.; Children Hospital 2, Ho Chi Minh City, Vietnam., Pham TTT; Epigenetic Unit, DNA Medical Technology, Ho Chi Minh City, Vietnam., Nakagawara A; Division of Innovative Cancer Therapeutics, Chiba Cancer Center Research Institute, Chiba, Japan., Bui CB; City Children's Hospital, Ho Chi Minh City, Vietnam.; Vietnam National University Ho Chi Minh city, Ho Chi Minh, Vietnam.; School of Medicine, Ho Chi Minh city, Vietnam. |
| المصدر: | Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society [Pediatr Dev Pathol] 2022 Mar-Apr; Vol. 25 (2), pp. 91-98. Date of Electronic Publication: 2021 Aug 30. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: SAGE Publishing Country of Publication: United States NLM ID: 9809673 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1615-5742 (Electronic) Linking ISSN: 10935266 NLM ISO Abbreviation: Pediatr Dev Pathol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2017-: Thousand Oaks, CA : SAGE Publishing Original Publication: New York, NY : Springer, c1998- |
| مواضيع طبية MeSH: | Cancer-Associated Fibroblasts*/metabolism , Cancer-Associated Fibroblasts*/pathology , Collagen Type XI*/genetics , Collagen Type XI*/metabolism , Neuroblastoma*/pathology, Child ; Collagen/metabolism ; Humans ; Infant ; Neoplasm Recurrence, Local/pathology ; Tumor Microenvironment |
| مستخلص: | Background: Neuroblastoma (NB) is among the most common cancers in children. A highly aggressive form of cancer, NB relies on cells in the microenvironment for dissemination particularly cancer associated fibroblast (CAFs). CAFs synthesise the extracellular matrix to create a scaffold for tumor growth thus enabling the carcinogenesis of NB, Collagen, an abundant scaffold protein produced by CAFs, has been implicated in the creation of an optimal tumor microenvironment, however, the expression profile of collagen within NB is not yet known. Methods: We characterised collagen expression within the tumor-stroma boundary by microarray and confirmed by qRT-PCR and immunohistochemistry. Results: The collagen marker, COL11A1, was also upregulated in NB CD45+ cells and SMA+ CAFs. Furthermore, SMA+ CAFs led to neuroblastoma cell invasion in an in vitro co-culture system which was subsequently attenuated by gene silencing COL11A1. Immunohistochemical staining of clinical tumor samples revealed that high COL11A1 expression in the stroma adjacent to tumour site, significantly associated with advanced cancer stages, age ≥18 months, undifferentiated tumor status, relapse and poor overall survival. Conclusion: Collectively, these results suggest that a COL11A1 signature in the NB microenvironment could represent a novel target for therapeutic intervention. |
| فهرسة مساهمة: | Keywords: COL11A1; cancer associated fibroblast; collagen; microenvironment; molecular oncology; neuroblastoma |
| المشرفين على المادة: | 0 (COL11A1 protein, human) 0 (Collagen Type XI) 9007-34-5 (Collagen) |
| تواريخ الأحداث: | Date Created: 20210830 Date Completed: 20220516 Latest Revision: 20220531 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1177/10935266211039200 |
| PMID: | 34460335 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1615-5742 |
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| DOI: | 10.1177/10935266211039200 |