دورية أكاديمية
أعرض في EDS

LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.

التفاصيل البيبلوغرافية
العنوان: LIN37-DREAM prevents DNA end resection and homologous recombination at DNA double-strand breaks in quiescent cells.
المؤلفون: Chen BR; Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, United States.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, United States., Wang Y; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States., Tubbs A; Laboratory of Genome Integrity, National Cancer Institute, Bethesda, United States., Zong D; Laboratory of Genome Integrity, National Cancer Institute, Bethesda, United States., Fowler FC; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States., Zolnerowich N; Laboratory of Genome Integrity, National Cancer Institute, Bethesda, United States., Wu W; Laboratory of Genome Integrity, National Cancer Institute, Bethesda, United States., Bennett A; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States., Chen CC; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States., Feng W; Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, United States., Nussenzweig A; Laboratory of Genome Integrity, National Cancer Institute, Bethesda, United States., Tyler JK; Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, United States., Sleckman BP; Division of Hematology and Oncology, Department of Medicine, University of Alabama at Birmingham, Birmingham, United States.; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, United States.
المصدر: ELife [Elife] 2021 Sep 03; Vol. 10. Date of Electronic Publication: 2021 Sep 03.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: eLife Sciences Publications, Ltd Country of Publication: England NLM ID: 101579614 Publication Model: Electronic Cited Medium: Internet ISSN: 2050-084X (Electronic) Linking ISSN: 2050084X NLM ISO Abbreviation: Elife Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Cambridge, UK : eLife Sciences Publications, Ltd., 2012-
مواضيع طبية MeSH: DNA Breaks, Double-Stranded* , DNA End-Joining Repair*, Rad51 Recombinase/*metabolism , Trans-Activators/*metabolism, BRCA1 Protein/metabolism ; DNA Repair Enzymes/metabolism ; DNA Replication ; G1 Phase ; G2 Phase ; Homologous Recombination ; Humans ; S Phase ; Trans-Activators/genetics ; Tumor Suppressor p53-Binding Protein 1/metabolism
مستخلص: DNA double-strand break (DSB) repair by homologous recombination (HR) is thought to be restricted to the S- and G 2 - phases of the cell cycle in part due to 53BP1 antagonizing DNA end resection in G 1 -phase and non-cycling quiescent (G 0 ) cells. Here, we show that LIN37, a component of the DREAM transcriptional repressor, functions in a 53BP1-independent manner to prevent DNA end resection and HR in G 0 cells. Loss of LIN37 leads to the expression of HR proteins, including BRCA1, BRCA2, PALB2, and RAD51, and promotes DNA end resection in G 0 cells even in the presence of 53BP1. In contrast to 53BP1-deficiency, DNA end resection in LIN37-deficient G 0 cells depends on BRCA1 and leads to RAD51 filament formation and HR. LIN37 is not required to protect DNA ends in cycling cells at G 1 -phase. Thus, LIN37 regulates a novel 53BP1-independent cell phase-specific DNA end protection pathway that functions uniquely in quiescent cells.
Competing Interests: BC, YW, AT, DZ, FF, NZ, WW, AB, CC, WF, AN, BS No competing interests declared, JT Senior editor, eLife
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معلومات مُعتمدة: R35 GM139816 United States GM NIGMS NIH HHS; P30 CA013148 United States CA NCI NIH HHS; R01 CA095641 United States CA NCI NIH HHS; R01 AI074953 United States AI NIAID NIH HHS; R01 GM064475 United States GM NIGMS NIH HHS; R01 AI047829 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: DSB repair; HR; LIN37; NHEJ; cell biology; chromosomes; gene expression; human; mouse; quiescence; resection
المشرفين على المادة: 0 (BRCA1 Protein)
0 (BRCA1 protein, human)
0 (Lin37 protein, human)
0 (TP53BP1 protein, human)
0 (Trans-Activators)
0 (Tumor Suppressor p53-Binding Protein 1)
EC 2.7.7.- (RAD51 protein, human)
EC 2.7.7.- (Rad51 Recombinase)
EC 6.5.1.- (DNA Repair Enzymes)
تواريخ الأحداث: Date Created: 20210903 Date Completed: 20211019 Latest Revision: 20211214
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8416021
DOI: 10.7554/eLife.68466
PMID: 34477552
قاعدة البيانات: MEDLINE
الوصف
تدمد:2050-084X
DOI:10.7554/eLife.68466