دورية أكاديمية
Contribution of non-selective membrane channels and receptors in epilepsy.
| العنوان: | Contribution of non-selective membrane channels and receptors in epilepsy. |
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| المؤلفون: | García-Rodríguez C; Instituto de Neurociencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Chile. Electronic address: claudia.garciar@postgrado.uv.cl., Bravo-Tobar ID; Instituto de Neurociencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Chile., Duarte Y; Center for Bioinformatics and Integrative Biology, Facultad de Ciencias de la Vida, Universidad Andres Bello, Santiago, Chile., Barrio LC; Hospital Ramon y Cajal-IRYCIS, Centro de Tecnología Biomédica de la Universidad Politécnica, Madrid, Spain., Sáez JC; Instituto de Neurociencia, Centro Interdisciplinario de Neurociencia de Valparaíso, Universidad de Valparaíso, Chile. Electronic address: juancarlos.saez@uv.cl. |
| المصدر: | Pharmacology & therapeutics [Pharmacol Ther] 2022 Mar; Vol. 231, pp. 107980. Date of Electronic Publication: 2021 Sep 03. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Pergamon Press Country of Publication: England NLM ID: 7905840 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-016X (Electronic) Linking ISSN: 01637258 NLM ISO Abbreviation: Pharmacol Ther Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, Elmsford, N. Y., Pergamon Press. |
| مواضيع طبية MeSH: | Epilepsy*/drug therapy , Epilepsy*/metabolism , Transient Receptor Potential Channels*/metabolism, Connexins/metabolism ; Humans ; Microglia/metabolism ; Nerve Tissue Proteins/metabolism ; Neurons/metabolism ; Seizures/metabolism |
| مستخلص: | Overcoming refractory epilepsy's resistance to the combination of antiepileptic drugs (AED), mitigating side effects, and preventing sudden unexpected death in epilepsy are critical goals for therapy of this disorder. Current therapeutic strategies are based primarily on neurocentric mechanisms, overlooking the participation of astrocytes and microglia in the pathophysiology of epilepsy. This review is focused on a set of non-selective membrane channels (permeable to ions and small molecules), including channels and ionotropic receptors of neurons, astrocytes, and microglia, such as: the hemichannels formed by Cx43 and Panx1; the purinergic P2X7 receptors; the transient receptor potential vanilloid (TRPV1 and TRPV4) channels; calcium homeostasis modulators (CALHMs); transient receptor potential canonical (TRPC) channels; transient receptor potential melastatin (TRPM) channels; voltage-dependent anion channels (VDACs) and volume-regulated anion channels (VRACs), which all have in common being activated by epileptic activity and the capacity to exacerbate seizure intensity. Specifically, we highlight evidence for the activation of these channels/receptors during epilepsy including neuroinflammation and oxidative stress, discuss signaling pathways and feedback mechanisms, and propose the functions of each of them in acute and chronic epilepsy. Studying the role of these non-selective membrane channels in epilepsy and identifying appropriate blockers for one or more of them could provide complementary therapies to better alleviate the disease. (Copyright © 2021 Elsevier Inc. All rights reserved.) |
| فهرسة مساهمة: | Keywords: CALHM1 channels; Epilepsy; Hemichannels; P2X receptors; TRP channels; VDACs; VRACs |
| المشرفين على المادة: | 0 (Connexins) 0 (Nerve Tissue Proteins) 0 (PANX1 protein, human) 0 (Transient Receptor Potential Channels) |
| تواريخ الأحداث: | Date Created: 20210905 Date Completed: 20220331 Latest Revision: 20220401 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.pharmthera.2021.107980 |
| PMID: | 34481811 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1879-016X |
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| DOI: | 10.1016/j.pharmthera.2021.107980 |