دورية أكاديمية
أعرض في EDS

Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism.

التفاصيل البيبلوغرافية
العنوان: Case report: hepatitis in a child infected with SARS-CoV-2 presenting toll-like receptor 7 Gln11Leu single nucleotide polymorphism.
المؤلفون: Pessoa NL; Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.; Imunologia de Doenças Virais, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil., Bentes AA; Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.; Hospital João Paulo II, Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, MG, Brazil., de Carvalho AL; Hospital João Paulo II, Fundação Hospitalar do Estado de Minas Gerais, Belo Horizonte, MG, Brazil., de Souza Silva TB; Imunologia de Doenças Virais, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil., Alves PA; Imunologia de Doenças Virais, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil., de Sousa Reis EV; Imunologia de Doenças Virais, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil., Rodrigues TA; Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.; Quibasa Química Básica, Belo Horizonte, MG, Brazil., Kroon EG; Laboratório de Vírus, Departamento de Microbiologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil., Campos MA; Imunologia de Doenças Virais, Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil. marco.campos@fiocruz.br.
المصدر: Virology journal [Virol J] 2021 Sep 05; Vol. 18 (1), pp. 180. Date of Electronic Publication: 2021 Sep 05.
نوع المنشور: Case Reports; Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101231645 Publication Model: Electronic Cited Medium: Internet ISSN: 1743-422X (Electronic) Linking ISSN: 1743422X NLM ISO Abbreviation: Virol J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: [London] : BioMed Central, 2004-
مواضيع طبية MeSH: COVID-19/*genetics , COVID-19/*virology , Hepatitis, Viral, Human/*genetics , Hepatitis, Viral, Human/*virology , Toll-Like Receptor 7/*genetics, Antibodies, Viral/blood ; COVID-19/immunology ; Child, Preschool ; Epstein-Barr Virus Infections/genetics ; Epstein-Barr Virus Infections/virology ; Feces/virology ; Hepatitis, Viral, Human/immunology ; Herpesvirus 4, Human/isolation & purification ; Humans ; Immunity, Innate ; Influenza, Human ; Male ; Polymorphism, Single Nucleotide ; SARS-CoV-2/isolation & purification
مستخلص: Background: Covid-19 has the respiratory tract as the main target of infection, and patients present mainly dyspnea, pneumonia, dry cough, and fever. Nevertheless, organs outside the respiratory tract had been reported in recent studies, including the gastrointestinal tract and liver. The host innate immune system recognizes pathogen-associated molecular patterns (PAMPs) through their pattern recognition receptor (PRRs). Toll-like receptor 7 (TLR-7) is a pattern recognition receptor recognizing ssRNA (SARS-CoV-2 is an ssRNA). Polymorphisms are characterized by two or more alternative forms of a distinct phenotype in the same population. Polymorphisms in tlrs genes can negatively influence the immune response to infectious diseases. There are several references in the literature to non-synonymous single nucleotide (rs) polymorphisms related to several genes. Some of them are important for the innate immunity, as rs 179008 (tlr-7), rs3775291 (tlr3), rs8177374 (tir domain-containing adaptor protein, tirap), rs1024611 (monocyte chemoattractant protein-1, mcp-1) and rs61942233 (2'-5'-oligoadenylate synthase-3, oas-3).
Case Presentation: We identified a 5-year-old-male child with gastrointestinal symptoms and fever presenting acholic stool and jaundice, who was positive for SARS-CoV-2 IgM, IgA, and IgG and presenting the Gln11Leu rs 179008 in tlr-7. The child presented high levels of aspartate aminotransferase, alanine aminotransferase, bilirubin, C-reactive protein, D-dimer, gamma-glutamyl transferase, alkaline phosphatase, and was negative for serological tests for hepatitis A, B, C, E, HIV 1 and 2, herpes virus, cytomegalovirus, Epstein-Barr virus, and negative for RTqPCR for Influenza A and B, RSV and SARS-CoV-2. We also investigated other SNPs in the tlr-3 (rs3775291), tirap (rs8177374), mcp-1 (rs1024611), and oas-3 (rs61942233) genes, and no mutation was detected. After an interview with the child's caregivers, any possible accidental ingestion of drugs or hepatotoxic substances was ruled out.
Conclusion: To our knowledge, this is the first report of a SARS-CoV-2 caused hepatitis in a male child that has the tlr-7 Gln11Leu rs 179008, which could impair an efficient initial immune response. The knowledge of the patient's immune deficiency could improve the treatment to correct this deficiency with specific medications.
(© 2021. The Author(s).)
التعليقات: Comment in: Int J Surg. 2022 Jun;102:106682. (PMID: 35597436)
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معلومات مُعتمدة: 2071001135/2020 Deputy state parliamentary MG, Beatriz Cerqueira; APQ-00846-20 FAPEMIG PPSUS
فهرسة مساهمة: Keywords: Children; Covid-19; Hepatitis; Innate immune defense; SARS-CoV-2; Single nucleotide polymorphism; TLR-7; Toll-like receptor 7 Gln11Leu; rs 179008
المشرفين على المادة: 0 (Antibodies, Viral)
0 (TLR7 protein, human)
0 (Toll-Like Receptor 7)
تواريخ الأحداث: Date Created: 20210906 Date Completed: 20210915 Latest Revision: 20220619
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8418785
DOI: 10.1186/s12985-021-01656-3
PMID: 34482844
قاعدة البيانات: MEDLINE
الوصف
تدمد:1743-422X
DOI:10.1186/s12985-021-01656-3