دورية أكاديمية
Biological effectiveness of He-3 and He-4 ion beams for cancer hadrontherapy: a study based on the BIANCA biophysical model.
| العنوان: | Biological effectiveness of He-3 and He-4 ion beams for cancer hadrontherapy: a study based on the BIANCA biophysical model. |
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| المؤلفون: | Carante MP; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, via Bassi 6, I-27100 Pavia, Italy.; University of Pavia, Physics Department, via Bassi 6, I-27100 Pavia, Italy., Embriaco A; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, via Bassi 6, I-27100 Pavia, Italy., Aricò G; CERN-European Organization for Nuclear Research, Geneva, Switzerland., Ferrari A; University Hospital Heidelberg, Germany.; Gangneung-Wonju National University-Gangneung, Republic of Korea., Mairani A; HIT (Heidelberg Ion-beam Therapy center), Heidelberg, Germany., Mein S; HIT (Heidelberg Ion-beam Therapy center), Heidelberg, Germany., Ramos R; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, via Bassi 6, I-27100 Pavia, Italy., Sala P; INFN (Italian National Institute for Nuclear Physics), Sezione di Milano, via Celoria 16, I-20133 Milano, Italy., Ballarini F; INFN (Italian National Institute for Nuclear Physics), Sezione di Pavia, via Bassi 6, I-27100 Pavia, Italy.; University of Pavia, Physics Department, via Bassi 6, I-27100 Pavia, Italy. |
| المصدر: | Physics in medicine and biology [Phys Med Biol] 2021 Sep 28; Vol. 66 (19). Date of Electronic Publication: 2021 Sep 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: IOP Publishing Country of Publication: England NLM ID: 0401220 Publication Model: Electronic Cited Medium: Internet ISSN: 1361-6560 (Electronic) Linking ISSN: 00319155 NLM ISO Abbreviation: Phys Med Biol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Bristol : IOP Publishing |
| مواضيع طبية MeSH: | Neoplasms*/radiotherapy , Proton Therapy*, Animals ; Cricetinae ; Cricetulus ; Humans ; Protons ; Relative Biological Effectiveness |
| مستخلص: | While cancer therapy with protons and C-ions is continuously spreading, in the near future patients will be also treated with He-ions which, in comparison to photons, combine the higher precision of protons with the higher relative biological effectiveness (RBE) of C-ions. Similarly to C-ions, also for He-ions the RBE variation along the beam must be known as precisely as possible, especially for active beam delivery systems. In this framework the BIANCA biophysical model, which has already been applied to calculate the RBE along proton and C-ion beams, was extended to 4 He-ions and, following interface with the FLUKA code, was benchmarked against cell survival data on CHO normal cells and Renca tumour cells irradiated at different positions along therapeutic-like 4 He-ion beams at the Heidelberg Ion-beam Therapy centre, where the first He-ion patient will be treated soon. Very good agreement between simulations and data was obtained, showing that BIANCA can now be used to predict RBE following irradiation with all ion types that are currently used, or will be used soon, for hadrontherapy. Thanks to the development of a reference simulation database describing V79 cell survival for ion and photon irradiation, these predictions can be cell-type specific because analogous databases can be produced, in principle, for any cell line. Furthermore, survival data on CHO cells irradiated by a He-3 beam were reproduced to compare the biophysical properties of He-4 and He-3 beams, which is currently an open question. This comparison showed that, at the same depth, He-4 beams tend to have a higher RBE with respect to He-3 beams, and that this difference is also modulated by the considered physical dose, as well as the cell radiosensitivity. However, at least for the considered cases, no significant difference was found for the ratio between the RBE-weighted dose in the SOBP and that in the entrance plateau. (© 2021 Institute of Physics and Engineering in Medicine.) |
| فهرسة مساهمة: | Keywords: He ions; Monte Carlo simulations; biophysical models; cell survival; hadrontherapy; relative biological effectiveness |
| المشرفين على المادة: | 0 (Protons) |
| تواريخ الأحداث: | Date Created: 20210910 Date Completed: 20220404 Latest Revision: 20220405 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1088/1361-6560/ac25d4 |
| PMID: | 34507306 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1361-6560 |
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| DOI: | 10.1088/1361-6560/ac25d4 |