دورية أكاديمية
أعرض في EDS

An update on oral drug delivery via intestinal lymphatic transport.

التفاصيل البيبلوغرافية
العنوان: An update on oral drug delivery via intestinal lymphatic transport.
المؤلفون: Zhang Z; Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China., Lu Y; Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China., Qi J; Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China., Wu W; Key Laboratory of Smart Drug Delivery of MOE, School of Pharmacy, Fudan University, Shanghai 201203, China.; Center for Medical Research and Innovation, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China.
المصدر: Acta pharmaceutica Sinica. B [Acta Pharm Sin B] 2021 Aug; Vol. 11 (8), pp. 2449-2468. Date of Electronic Publication: 2021 Apr 09.
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: Netherlands NLM ID: 101600560 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2211-3835 (Print) Linking ISSN: 22113835 NLM ISO Abbreviation: Acta Pharm Sin B Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Amsterdam] : Elsevier, 2011-
مستخلص: Orally administered drug entities have to survive the harsh gastrointestinal environment, penetrate the enteric epithelia and circumvent hepatic metabolism before reaching the systemic circulation. Whereas the gastrointestinal stability can be well maintained by taking proper measures, hepatic metabolism presents as a formidable barrier to drugs suffering from first-pass metabolism. The pharmaceutical academia and industries are seeking alternative pathways for drug transport to circumvent problems associated with the portal pathway. Intestinal lymphatic transport is emerging as a promising pathway to this end. In this review, we intend to provide an updated overview on the rationale, strategies, factors and applications involved in intestinal lymphatic transport. There are mainly two pathways for peroral lymphatic transport-the chylomicron and the microfold cell pathways. The underlying mechanisms are being unraveled gradually and nowadays witness increasing research input and applications.
Competing Interests: The authors have no conflicts of interest to declare.
(© 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.)
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فهرسة مساهمة: Keywords: ACQ, aggregation-caused quenching; ASRT, apical sodium-dependent bile acid transporter; AUC, area under curve; BCS, biopharmaceutics classification system; CM, chylomicron; Chylomicron; DC, dendritic cell; DDT, dichlorodiphenyltrichloroethane; DTX, docetaxel; Drug absorption; Drug carriers; Drug delivery; FA, fatty acid; FAE, follicle-associated epithelia; FRET, Föster resonance energy transfer; GIT, gastrointestinal tract; HBsAg, hepatitis B surface antigen; HIV, human immunodeficiency virus; LDL, low-density lipoprotein; LDV, Leu-Asp-Val; LDVp, LDV peptidomimetic; Lymphatic transport; M cell, microfold cells; MG, monoglyceride; MPA, mycophenolic acid; MPS, mononuclear phagocyte system; Microfold cell; Nanoparticles; OA, oleate; Oral; PCL, polycaprolactone; PEG-PLA, polyethylene glycol-poly(lactic acid); PEI, polyethyleneimine; PLGA, poly(lactic-co-glycolic acid); PVA, poly(vinyl alcohol); RGD, Arg-Gly-Asp; RGDp, RGD peptidomimetic; SEDDS, self-emulsifying drug delivery system; SLN, solid lipid nanoparticles; SNEDDS, self-nanoemulsifying drug delivery system; TEM, transmission electron microscopy; TG, triglyceride; TPGS, D-α-tocopherol polyethylene glycol 1000 succinate; TU, testosterone undecanoate; WGA, wheat germ agglutinin; YCW, yeast cell wall
تواريخ الأحداث: Date Created: 20210915 Latest Revision: 20240403
رمز التحديث: 20240403
مُعرف محوري في PubMed: PMC8424224
DOI: 10.1016/j.apsb.2020.12.022
PMID: 34522594
قاعدة البيانات: MEDLINE
الوصف
تدمد:2211-3835
DOI:10.1016/j.apsb.2020.12.022