دورية أكاديمية
Cerebellar Dentate Connectivity across Adulthood: A Large-Scale Resting State Functional Connectivity Investigation.
| العنوان: | Cerebellar Dentate Connectivity across Adulthood: A Large-Scale Resting State Functional Connectivity Investigation. |
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| المؤلفون: | Bernard JA; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX 77843, USA., Ballard HK; Texas A&M Institute for Neuroscience, Texas A&M University, College Station, TX 77843, USA., Jackson TB; Department of Psychological and Brain Sciences, Texas A&M University, College Station, TX 77843, USA. |
| المصدر: | Cerebral cortex communications [Cereb Cortex Commun] 2021 Aug 10; Vol. 2 (3), pp. tgab050. Date of Electronic Publication: 2021 Aug 10 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: United States NLM ID: 101767128 Publication Model: eCollection Cited Medium: Internet ISSN: 2632-7376 (Electronic) Linking ISSN: 26327376 NLM ISO Abbreviation: Cereb Cortex Commun Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Cary, N.C. : Oxford University Press, [2020]- |
| مستخلص: | Cerebellar contributions to behavior in advanced age are of interest and importance, given its role in motor and cognitive performance. There are differences and declines in cerebellar structure in advanced age and cerebellar resting state connectivity is lower. However, the work on this area to date has focused on the cerebellar cortex. The deep cerebellar nuclei provide the primary cerebellar inputs and outputs to the cortex, as well as the spinal and vestibular systems. Dentate networks can be dissociated such that the dorsal region is associated with the motor cortex, whereas the ventral aspect is associated with the prefrontal cortex. However, whether dentato-thalamo-cortical networks differ across adulthood remains unknown. Here, using a large adult sample ( n = 590) from the Cambridge Center for Ageing and Neuroscience, we investigated dentate connectivity across adulthood. We replicated past work showing dissociable resting state networks in the dorsal and ventral aspects of the dentate. In both seeds, we demonstrated that connectivity is lower with advanced age, indicating that connectivity differences extend beyond the cerebellar cortex. Finally, we demonstrated sex differences in dentate connectivity. This expands our understanding of cerebellar circuitry in advanced age and underscores the potential importance of this structure in age-related performance differences. (© The Author(s) 2021. Published by Oxford University Press.) |
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| معلومات مُعتمدة: | BB/H008217/1 United Kingdom BB_ Biotechnology and Biological Sciences Research Council; R01 AG064010 United States AG NIA NIH HHS |
| فهرسة مساهمة: | Keywords: aging; cerebellum; dentate; resting state connectivity; sex differences |
| تواريخ الأحداث: | Date Created: 20210916 Latest Revision: 20220413 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8436571 |
| DOI: | 10.1093/texcom/tgab050 |
| PMID: | 34527949 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2632-7376 |
|---|---|
| DOI: | 10.1093/texcom/tgab050 |