دورية أكاديمية
أعرض في EDS

Association between incidental statin use and skeletal myopathies in patients treated with immune checkpoint inhibitors.

التفاصيل البيبلوغرافية
العنوان: Association between incidental statin use and skeletal myopathies in patients treated with immune checkpoint inhibitors.
المؤلفون: Drobni ZD; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Murphy SP; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Alvi RM; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Lee C; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gong J; Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA., Mosarla RC; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Rambarat PK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Hartmann SB; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Gilman HK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zubiri L; Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Raghu VK; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sullivan RJ; Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zafar A; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Zlotoff DA; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Sise ME; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Guidon AC; Division of Neuromuscular Medicine, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Reynolds KL; Division of Oncology and Hematology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Dougan M; Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA., Neilan TG; Cardiovascular Imaging Research Center, Department of Radiology and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.; Cardio-Oncology Program, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
المصدر: Immunotherapy advances [Immunother Adv] 2021 Jun 16; Vol. 1 (1), pp. ltab014. Date of Electronic Publication: 2021 Jun 16 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Oxford University Press Country of Publication: England NLM ID: 101776979 Publication Model: eCollection Cited Medium: Internet ISSN: 2732-4303 (Electronic) Linking ISSN: 27324303 NLM ISO Abbreviation: Immunother Adv Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Oxford] : Oxford University Press, [2021]-
مستخلص: Objectives: Skeletal myopathies are highly morbid, and in rare cases even fatal, immune-related adverse events (irAE) associated with immune checkpoint inhibitors (ICI). Skeletal myopathies are also a recognized statin-associated side effect. It is unknown whether concurrent use of statins and ICIs increases the risk of skeletal myopathies.
Methods: This was a retrospective cohort study of all patients who were treated with an ICI at a single academic institution (Massachusetts General Hospital, Boston, MA, USA). The primary outcome of interest was the development of a skeletal myopathy. The secondary outcome of interest was an elevated creatine kinase level (above the upper limit of normal).
Results: Among 2757 patients, 861 (31.2%) were treated with a statin at the time of ICI start. Statin users were older, more likely to be male and had a higher prevalence of cardiovascular and non-cardiovascular co-morbidities. During a median follow-up of 194 days (inter quartile range 65-410), a skeletal myopathy occurred in 33 patients (1.2%) and was more common among statin users (2.7 vs. 0.9%, P < 0.001). Creatine kinase (CK) elevation was present in 16.3% (114/699) and was higher among statin users (20.0 vs. 14.3%, P = 0.067). In a multivariable Cox model, statin therapy was associated with a >2-fold higher risk for skeletal myopathy (HR, 2.19; 95% confidence interval, 1.07-4.50; P = 0.033).
Conclusion: In this large cohort of ICI-treated patients, a higher risk was observed for skeletal myopathies and elevation in CK levels in patients undergoing concurrent statin therapy. Prospective observational studies are warranted to further elucidate the potential association between statin use and ICI-associated myopathies.
(© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Immunology.)
References: Circulation. 2016 Mar 15;133(11):1104-14. (PMID: 26976915)
Circulation. 2018 Aug 14;138(7):743-745. (PMID: 30359135)
JACC CardioOncol. 2021 Mar;3(1):35-47. (PMID: 33842895)
Front Oncol. 2019 Jun 20;9:530. (PMID: 31293970)
Int J Mol Sci. 2020 Apr 26;21(9):. (PMID: 32357515)
J Neuromuscul Dis. 2018;5(2):109-129. (PMID: 29865091)
Curr Drug Saf. 2018;13(3):150-164. (PMID: 29745339)
N Engl J Med. 2018 Jan 11;378(2):158-168. (PMID: 29320654)
Circulation. 2020 Jun 16;141(24):2031-2034. (PMID: 32539614)
Eur Heart J. 2020 May 7;41(18):1733-1743. (PMID: 32112560)
Clin Pharmacol Ther. 2014 Oct;96(4):470-6. (PMID: 24897241)
Circulation. 2020 Dec 15;142(24):2299-2311. (PMID: 33003973)
Nat Rev Drug Discov. 2014 Dec;13(12):883-4. (PMID: 25345674)
J Am Coll Cardiol. 2018 Apr 24;71(16):1755-1764. (PMID: 29567210)
Semin Arthritis Rheum. 2019 Feb;48(4):736-740. (PMID: 29909921)
Circulation. 2019 Jun 18;139(25):e1082-e1143. (PMID: 30586774)
Eur Heart J. 2019 Dec 21;40(48):3889-3897. (PMID: 31761945)
J Clin Oncol. 2016 Apr 1;34(10):1122-30. (PMID: 26834065)
Ann Rheum Dis. 2018 Mar;77(3):393-398. (PMID: 29146737)
RMD Open. 2017 Mar 20;3(1):e000412. (PMID: 28405474)
Science. 2020 Jan 31;367(6477):. (PMID: 32001626)
Arterioscler Thromb Vasc Biol. 2019 Feb;39(2):e38-e81. (PMID: 30580575)
Indian J Nephrol. 2015 Jan-Feb;25(1):54-6. (PMID: 25684874)
Cancer Treat Rev. 2017 Jun;57:36-49. (PMID: 28550712)
JAMA Oncol. 2018 Dec 1;4(12):1721-1728. (PMID: 30242316)
Oncologist. 2018 Sep;23(9):991-997. (PMID: 29853659)
J Immunother Cancer. 2019 Feb 22;7(1):53. (PMID: 30795818)
JAMA Netw Open. 2020 Mar 2;3(3):e200423. (PMID: 32150268)
J Am Soc Nephrol. 2020 Feb;31(2):435-446. (PMID: 31896554)
Neurology. 2018 Sep 4;91(10):e985-e994. (PMID: 30089619)
Immunotherapy. 2019 Nov;11(16):1409-1422. (PMID: 31621445)
Curr Rheumatol Rep. 2019 Feb 21;21(4):10. (PMID: 30790071)
J Am Coll Cardiol. 2020 Feb 11;75(5):467-478. (PMID: 32029128)
J Am Coll Cardiol. 2021 Mar 30;77(12):1503-1516. (PMID: 33766256)
Kidney Int. 2016 Sep;90(3):638-47. (PMID: 27282937)
Arthritis Care Res (Hoboken). 2017 Nov;69(11):1751-1763. (PMID: 27998041)
Nephrol Dial Transplant. 2004 Dec;19(12):3176-9. (PMID: 15575008)
JAMA Cardiol. 2017 Jan 1;2(1):56-65. (PMID: 27842171)
J Immunother Cancer. 2019 Jan 6;7(1):2. (PMID: 30612580)
Ann Rheum Dis. 2020 Feb 17;:. (PMID: 32066555)
معلومات مُعتمدة: K08 DK114563 United States DK NIDDK NIH HHS; K24 HL150238 United States HL NHLBI NIH HHS
فهرسة مساهمة: Keywords: immune checkpoint inhibitors; immune-related adverse events; skeletal myopathy; statin therapy
تواريخ الأحداث: Date Created: 20210920 Latest Revision: 20220426
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8444991
DOI: 10.1093/immadv/ltab014
PMID: 34541581
قاعدة البيانات: MEDLINE
الوصف
تدمد:2732-4303
DOI:10.1093/immadv/ltab014