دورية أكاديمية
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The Effects of General Anaesthesia and Light on Behavioural Rhythms and GABA A Receptor Subunit Expression in the Mouse SCN.

التفاصيل البيبلوغرافية
العنوان: The Effects of General Anaesthesia and Light on Behavioural Rhythms and GABA A Receptor Subunit Expression in the Mouse SCN.
المؤلفون: Chong J; Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland 1142, New Zealand., Cheeseman JF; Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland 1142, New Zealand., Pawley MDM; Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland 1142, New Zealand.; School of Natural and Computational Sciences, Massey University, Auckland 0745, New Zealand., Kwakowsky A; Department of Anatomy and Medical Imaging, School of Medical Sciences, University of Auckland, Auckland 1142, New Zealand., Warman GR; Department of Anaesthesiology, School of Medicine, University of Auckland, Auckland 1142, New Zealand.
المصدر: Clocks & sleep [Clocks Sleep] 2021 Sep 17; Vol. 3 (3), pp. 482-494. Date of Electronic Publication: 2021 Sep 17.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 101736579 Publication Model: Electronic Cited Medium: Internet ISSN: 2624-5175 (Electronic) Linking ISSN: 26245175 NLM ISO Abbreviation: Clocks Sleep Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: [Basel, Switzerland] : MDPI, [2019]-
مستخلص: General anaesthesia (GA) is known to affect the circadian clock. However, the mechanisms that underlie GA-induced shifting of the clock are less well understood. Activation of γ-aminobutyric acid (GABA) - type A receptors (GABA A R) in the suprachiasmatic nucleus (SCN) can phase shift the clock and thus GABA and its receptors represent a putative pathway via which GA exerts its effect on the clock. Here, we investigated the concurrent effects of the inhalational anaesthetic, isoflurane, and light, on mouse behavioural locomotor rhythms and on α1, β3, and γ2 GABA A R subunit expression in the SCN of the mouse brain. Behavioural phase shifts elicited by exposure of mice to four hours of GA (2% isoflurane) and light (400 lux) (n = 60) were determined by recording running wheel activity rhythms in constant conditions (DD). Full phase response curves for the effects of GA + light on behavioural rhythms show that phase shifts persist in anaesthetized mice exposed to light. Daily variation was detected in all three GABA A R subunits in LD 12:12. The γ2 subunit expression was significantly increased following GA in DD (compared to light alone) at times of large behavioural phase delays. We conclude that the phase shifting effect of light on the mouse clock is not blocked by GA administration, and that γ2 may potentially be involved in the phase shifting effect of GA on the clock. Further analysis of GABA A R subunit expression in the SCN will be necessary to confirm its role.
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معلومات مُعتمدة: School of Medicine PBRF fund University of Auckland
فهرسة مساهمة: Keywords: GABA; GABAA receptor; circadian clock; general anaesthesia; phase response curve
تواريخ الأحداث: Date Created: 20210925 Latest Revision: 20211002
رمز التحديث: 20240628
مُعرف محوري في PubMed: PMC8482144
DOI: 10.3390/clockssleep3030034
PMID: 34563056
قاعدة البيانات: MEDLINE
الوصف
تدمد:2624-5175
DOI:10.3390/clockssleep3030034