دورية أكاديمية
Maternal sucrose consumption alters behaviour and steroids in adult rat offspring.
| العنوان: | Maternal sucrose consumption alters behaviour and steroids in adult rat offspring. |
|---|---|
| المؤلفون: | Tobiansky DJ; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada.; Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada., Kachkovski GV; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada., Enos RT; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA., Schmidt KL; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada., Murphy EA; Department of Pathology, Microbiology, and Immunology, School of Medicine, University of South Carolina, Columbia, South Carolina, USA., Floresco SB; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada.; Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada., Soma KK; Department of Psychology, The University of British Columbia, Vancouver, British Columbia, Canada.; Djavad Mowafaghian Centre for Brain Health, The University of British Columbia, Vancouver, British Columbia, Canada.; Department of Zoology, The University of British Columbia, Vancouver, British Columbia, Canada. |
| المصدر: | The Journal of endocrinology [J Endocrinol] 2021 Nov 05; Vol. 251 (3), pp. 161-180. Date of Electronic Publication: 2021 Nov 05. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioScientifica Country of Publication: England NLM ID: 0375363 Publication Model: Electronic Cited Medium: Internet ISSN: 1479-6805 (Electronic) Linking ISSN: 00220795 NLM ISO Abbreviation: J Endocrinol Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Jan. 2011- : Bristol, UK : BioScientifica Original Publication: Bristol, UK : Society for Endocrinology |
| مواضيع طبية MeSH: | Prenatal Nutritional Physiological Phenomena*, Behavior, Animal/*drug effects , Brain/*metabolism , Steroids/*metabolism , Sucrose/*administration & dosage, Animal Feed ; Animals ; Biomarkers ; Choice Behavior/drug effects ; Diet ; Energy Metabolism/drug effects ; Energy Metabolism/physiology ; Female ; Gene Expression Regulation/drug effects ; Pregnancy ; RNA, Messenger/genetics ; RNA, Messenger/metabolism ; Random Allocation ; Rats ; Receptors, Dopamine/genetics ; Receptors, Dopamine/metabolism ; Receptors, Steroid/genetics ; Receptors, Steroid/metabolism |
| مستخلص: | Maternal diets can have dramatic effects on the physiology, metabolism, and behaviour of offspring that persist into adulthood. However, the effects of maternal sucrose consumption on offspring remain unclear. Here, female rats were fed either a sucrose diet with a human-relevant level of sucrose (25% of kcal) or a macronutrient-matched, isocaloric control diet before, during, and after pregnancy. After weaning, all offspring were fed a standard low-sucrose rodent chow. We measured indicators of metabolism (weight, adipose, glucose tolerance, and liver lipids) during development and adulthood (16-24 weeks). We also measured food preference and motivation for sugar rewards in adulthood. Finally, in brain regions regulating these behaviours, we measured steroids and transcripts for steroidogenic enzymes, steroid receptors, and dopamine receptors. In male offspring, maternal sucrose intake decreased body mass and visceral adipose tissue, increased preference for high-sucrose and high-fat diets, increased motivation for sugar rewards, and decreased mRNA levels of Cyp17a1 (an androgenic enzyme) in the nucleus accumbens. In female offspring, maternal sucrose intake increased basal corticosterone levels. These data demonstrate the enduring, diverse, and sex-specific effects of maternal sucrose consumption on offspring phenotype. |
| معلومات مُعتمدة: | 133606 Canada CIHR; 426459 Canada CIHR |
| فهرسة مساهمة: | Keywords: mass spectrometry; mesocorticolimbic system; neurosteroids; progressive ratio; sugar |
| المشرفين على المادة: | 0 (Biomarkers) 0 (RNA, Messenger) 0 (Receptors, Dopamine) 0 (Receptors, Steroid) 0 (Steroids) 57-50-1 (Sucrose) |
| تواريخ الأحداث: | Date Created: 20210928 Date Completed: 20211221 Latest Revision: 20211221 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1530/JOE-21-0166 |
| PMID: | 34582358 |
| قاعدة البيانات: | MEDLINE |
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