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A numerical study to investigate the effects of tumour position on the treatment of bladder cancer in mice using gold nanorods assisted photothermal ablation.

التفاصيل البيبلوغرافية
العنوان: A numerical study to investigate the effects of tumour position on the treatment of bladder cancer in mice using gold nanorods assisted photothermal ablation.
المؤلفون: Cheong JK; Ascend Technologies Ltd, Southampton Science Park, 2 Venture Road, SO16 7NP, Southampton, United Kingdom; School of Engineering and Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia., Popov V; Ascend Technologies Ltd, Southampton Science Park, 2 Venture Road, SO16 7NP, Southampton, United Kingdom. Electronic address: viktor@ascendtechnologies.co.uk., Alchera E; Division of Experimental Oncology/Unit of Urology, URI, IRCCS, Ospedale San Raffaele, Milan, Italy., Locatelli I; Division of Experimental Oncology/Unit of Urology, URI, IRCCS, Ospedale San Raffaele, Milan, Italy., Alfano M; Division of Experimental Oncology/Unit of Urology, URI, IRCCS, Ospedale San Raffaele, Milan, Italy. Electronic address: alfano.massimo@hsr.it., Menichetti L; Istituto di Fisiologia Clinica, Sede Principale, Via G. Moruzzi 1, 56124, Pisa, Italy., Armanetti P; Istituto di Fisiologia Clinica, Sede Principale, Via G. Moruzzi 1, 56124, Pisa, Italy., Maturi M; Department of Industrial Chemistry Toso Montanari, University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy., Franchini MC; Department of Industrial Chemistry Toso Montanari, University of Bologna, Viale Risorgimento 4, 40136, Bologna, Italy., Ooi EH; Ascend Technologies Ltd, Southampton Science Park, 2 Venture Road, SO16 7NP, Southampton, United Kingdom; School of Engineering and Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia. Electronic address: ooi.ean.hin@monash.edu., Chiew YS; School of Engineering and Advanced Engineering Platform, Monash University Malaysia, Jalan Lagoon Selatan, 47500, Bandar Sunway, Selangor, Malaysia.
المصدر: Computers in biology and medicine [Comput Biol Med] 2021 Nov; Vol. 138, pp. 104881. Date of Electronic Publication: 2021 Sep 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Elsevier Country of Publication: United States NLM ID: 1250250 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1879-0534 (Electronic) Linking ISSN: 00104825 NLM ISO Abbreviation: Comput Biol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: New York : Elsevier
Original Publication: New York, Pergamon Press.
مواضيع طبية MeSH: Hyperthermia, Induced* , Nanotubes* , Urinary Bladder Neoplasms*/therapy, Animals ; Cell Line, Tumor ; Gold ; Humans ; Lasers ; Mice
مستخلص: Gold nanorods assisted photothermal therapy (GNR-PTT) is a new cancer treatment technique that has shown promising potential for bladder cancer treatment. The position of the bladder cancer at different locations along the bladder wall lining can potentially affect the treatment efficacy since laser is irradiated externally from the skin surface. The present study investigates the efficacy of GNR-PTT in the treatment of bladder cancer in mice for tumours growing at three different locations on the bladder, i.e., Case 1: closest to skin surface, Case 2: at the bottom half of the bladder, and Case 3: at the side of the bladder. Investigations were carried out numerically using an experimentally validated framework for optical-thermal simulations. An in-silico approach was adopted due to the flexibility in placing the tumour at a desired location along the bladder lining. Results indicate that for the treatment parameters considered (laser power 0.3 W, GNR volume fraction 0.01% v/v), only Case 1 can be used for an effective GNR-PTT. No damage to the tumour was observed in Cases 2 and 3. Analysis of the thermo-physiological responses showed that the effectiveness of GNR-PTT in treating bladder cancer depends not only on the depth of the tumour from the skin surface, but also on the type of tissue that the laser must pass through before reaching the tumour. In addition, the results are reliant on GNRs with a diameter of 10 nm and an aspect ratio of 3.8 - tuned to exhibit peak absorption for the chosen laser wavelength. Results from the present study can be used to highlight the potential for using GNR-PTT for treatment of human bladder cancer. It appears that Cases 2 and 3 suggest that GNR-PTT, where the laser passes through the skin to reach the bladder, may be unfeasible in humans. While this study shows the feasibility of using GNRs for photothermal ablation of bladder cancer, it also identifies the current limitations needed to be overcome for an effective clinical application in the bladder cancer patients.
(Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved.)
فهرسة مساهمة: Keywords: Bladder cancer; GNR; Laser therapy; Nanoparticles; Thermal therapy
المشرفين على المادة: 7440-57-5 (Gold)
تواريخ الأحداث: Date Created: 20210928 Date Completed: 20211104 Latest Revision: 20211104
رمز التحديث: 20221213
DOI: 10.1016/j.compbiomed.2021.104881
PMID: 34583149
قاعدة البيانات: MEDLINE
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