دورية أكاديمية
أعرض في EDS

Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation.

التفاصيل البيبلوغرافية
العنوان: Monocyte Reconstitution and Gut Microbiota Composition after Hematopoietic Stem Cell Transplantation.
المؤلفون: Morjaria S; Infectious Disease, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Zhang AW; Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA., Kim S; Immunology Program and Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Peled JU; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Becattini S; Immunology Program and Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Littmann ER; Immunology Program and Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA., Pamer EG; Infectious Disease, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Immunology Program and Infectious Disease Service, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.; Lucielle Castori Center for Microbes, Inflammation and Cancer, Sloan Kettering Institute, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA., Abt MC; Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA., Perales MA; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.; Department of Medicine, Weill Cornell Medical College, New York, NY, USA.
المصدر: Clinical hematology international [Clin Hematol Int] 2020 Nov 23; Vol. 2 (4), pp. 156-164. Date of Electronic Publication: 2020 Nov 23 (Print Publication: 2020).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: International Academy for Clinical Hematology Country of Publication: England NLM ID: 101759455 Publication Model: eCollection Cited Medium: Internet ISSN: 2590-0048 (Electronic) Linking ISSN: 25900048 NLM ISO Abbreviation: Clin Hematol Int Subsets: PubMed not MEDLINE
أسماء مطبوعة: Publication: 2023- : London : International Academy for Clinical Hematology
Original Publication: [Paris, France] : Atlantis Press International, [2019]-
مستخلص: Background: Monocytes are an essential cellular component of the innate immune system that support the host's effectiveness to combat a range of infectious pathogens. Hemopoietic cell transplantation (HCT) results in transient monocyte depletion, but the factors that regulate recovery of monocyte populations are not fully understood. In this study, we investigated whether the composition of the gastrointestinal microbiota is associated with the recovery of monocyte homeostasis after HCT.
Methods: We performed a single-center, prospective, pilot study of 18 recipients of either autologous or allogeneic HCT. Serial blood and stool samples were collected from each patient during their HCT hospitalization. Analysis of the gut microbiota was done using 16S rRNA gene sequencing, and flow cytometric analysis was used to characterize the phenotypic composition of monocyte populations.
Results: Dynamic fluctuations in monocyte reconstitution occurred after HCT, and large differences were observed in monocyte frequency among patients over time. Recovery of absolute monocyte counts and subsets showed significant variability across the heterogeneous transplant types and conditioning intensities; no relationship to the microbiota composition was observed in this small cohort.
Conclusion: In this pilot study, a relationship between the microbiota composition and monocyte homeostasis could not be firmly established. However, we identify multivariate associations between clinical factors and monocyte reconstitution post-HCT. Our findings encourage further longitudinal surveillance of the intestinal microbiome and its link to immune reconstitution.
Competing Interests: Dr. Perales reports honoraria from Abbvie, Bellicum, Bristol-Myers Squibb, Incyte, Merck, Novartis, Nektar Therapeutics, Omeros, and Takeda. He serves on DSMBs for Servier and Medigene, and the scientific advisory boards of MolMed and NexImmune. He has received research support for clinical trials from Incyte, Kite/Gilead and Miltenyi Biotec. He serves in a volunteer capacity as a member of the Board of Directors of American Society for Transplantation and Cellular Therapy (ASTCT) and Be The Match (National Marrow Donor Program, NMDP), as well as on the CIBMTR Cellular Immunotherapy Data Resource (CIDR) Committee. The other authors declare no conflict of interests.
(© 2020 International Academy for Clinical Hematology. Publishing services by Atlantis Press International B.V.)
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معلومات مُعتمدة: R00 AI125786 United States AI NIAID NIH HHS
فهرسة مساهمة: Keywords: Immune reconstitution; bone marrow transplantation; microbiome; monocytes
تواريخ الأحداث: Date Created: 20211001 Latest Revision: 20231215
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8432405
DOI: 10.2991/chi.k.201108.002
PMID: 34595456
قاعدة البيانات: MEDLINE
الوصف
تدمد:2590-0048
DOI:10.2991/chi.k.201108.002