دورية أكاديمية
Antidiabetic Effects and Antioxidant Properties of the Saggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), in Streptozotocin-Induced Hyperglycemic Rats.
| العنوان: | Antidiabetic Effects and Antioxidant Properties of the Saggy Ink Cap Medicinal Mushroom, Coprinus comatus (Agaricomycetes), in Streptozotocin-Induced Hyperglycemic Rats. |
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| المؤلفون: | Husen F; Biology Department, Faculty of Biology, Universitas Jenderal Soedirman, Karangwangkal, Banyumas 53122, Indonesia., Hernayanti H; Biology Department, Faculty of Biology, Universitas Jenderal Soedirman, Karangwangkal, Banyumas 53122, Indonesia., Ekowati N; Biology Department, Faculty of Biology, Universitas Jenderal Soedirman, Karangwangkal, Banyumas 53122, Indonesia., Sukmawati D; Biology Department, Universitas Negeri Jakarta, Rawamangun, Pulo Gadung, Jakarta 13220, Indonesia., Ratnaningtyas NI; Biology Department, Faculty of Biology, Universitas Jenderal Soedirman, Karangwangkal, Banyumas 53122, Indonesia. |
| المصدر: | International journal of medicinal mushrooms [Int J Med Mushrooms] 2021; Vol. 23 (10), pp. 9-21. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Begell House, Inc Country of Publication: United States NLM ID: 100886202 Publication Model: Print Cited Medium: Internet ISSN: 1940-4344 (Electronic) Linking ISSN: 19404344 NLM ISO Abbreviation: Int J Med Mushrooms Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Begell House, Inc., c1999- |
| مواضيع طبية MeSH: | Agaricales* , Coprinus*, Animals ; Antioxidants ; Blood Glucose ; Hypoglycemic Agents ; Ink ; Plant Extracts ; Rats ; Rats, Wistar ; Streptozocin |
| مستخلص: | Coprinus comatus is known for its antihyperglycemic benefits. This study aimed to identify the effect of bioactive compounds of C. comatus extract as an antidiabetic agent linked to glucagon-like peptide 1 (GLP-1) and antioxidant properties in increasing glutathione (GSH) levels. This study used six groups of Wistar rats (n = 24). Group 1 comprised the healthy control. Groups 2-6 received 45 mg of streptozotocin/kg body weight (BW) once. Group 3 was also given 45 mg of metformin/kg BW, whereas groups 4-6 were also given 250, 500, and 750 mg of C. comatus ethyl acetate extract/kg BW for 14 days. Antidiabetic effects of alkaloids and saponin were seen in blood glucose and glycated hemoglobin (HbA1c) degradation, increased insulin, and increased inhibition of GLP-1 through dipeptidyl peptidase-4 activity. Flavonoid antioxidants, ascorbic acid (vitamin C), and α-tocopherol (vitamin E) are useful in protecting pancreatic в cells from free radicals. Data were analyzed using analysis of variance and Duncan's multiple range test. C. comatus ethyl acetate extract at doses of 250, 500, and 750 mg/kg BW worked as an antidiabetic and antioxidant agent that contained flavonoids (16.4 mg/L), alkaloids (2.97 mg/L), saponin, rutin (351.13 ppm), vitamin C (132.342 mg/L), and vitamin E (102.320 g/L). The 250-mg dose was effective in increasing insulin (8.11 mlU/mL) and reducing blood glucose (23.92%) and HbA1c (3.775%), whereas the 500-mg dose was effective in increasing levels of GLP-1 (1056.923 ng/L) and GSH (4.62 μmol/L). |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Blood Glucose) 0 (Hypoglycemic Agents) 0 (Plant Extracts) 5W494URQ81 (Streptozocin) |
| SCR Organism: | Coprinus comatus |
| تواريخ الأحداث: | Date Created: 20211001 Date Completed: 20211125 Latest Revision: 20211125 |
| رمز التحديث: | 20231215 |
| DOI: | 10.1615/IntJMedMushrooms.2021040020 |
| PMID: | 34595888 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1940-4344 |
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| DOI: | 10.1615/IntJMedMushrooms.2021040020 |