دورية أكاديمية
Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization.
| العنوان: | Chronic exposure to lead acetate promotes changes in the alveolar bone of rats: microstructural and physical-chemical characterization. |
|---|---|
| المؤلفون: | Davis LL; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil., Aragão WAB; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil., de Oliveira Lopes G; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil., Eiró LG; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil., Freire AR; Laboratory of research in Mechanobiology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil., Prado FB; Laboratory of research in Mechanobiology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil., Rossi AC; Laboratory of research in Mechanobiology, Piracicaba Dental School, University of Campinas - UNICAMP, Piracicaba, Brazil., da Silva Cruz A; Group of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil., das Graças Fernandes Dantas K; Group of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil., Albuquerque ARL; Group of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil., Paz SPA; Group of Applied Analytical Spectrometry, Institute of Natural and Exact Sciences, Federal University of Pará, Belém, PA, Brazil., Angélica RS; Laboratory of Mineral Characterization, Institute of Geology and Geochemistry, Federal University of Pará, Belém, PA, Brazil., Lima RR; Laboratory of Functional and Structural Biology, Institute of Biological Sciences, Federal University of Pará, Augusto Corrêa street, N. 1. Campus do Guamá. - CEP, Belém, PA, 66075-110, Brazil. rafalima@ufpa.br. |
| المصدر: | Environmental science and pollution research international [Environ Sci Pollut Res Int] 2022 Feb; Vol. 29 (10), pp. 13930-13940. Date of Electronic Publication: 2021 Oct 02. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Springer Country of Publication: Germany NLM ID: 9441769 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1614-7499 (Electronic) Linking ISSN: 09441344 NLM ISO Abbreviation: Environ Sci Pollut Res Int Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: <2013->: Berlin : Springer Original Publication: Landsberg, Germany : Ecomed |
| مواضيع طبية MeSH: | Bone and Bones* , Lead*, Acetates ; Animals ; Rats ; Rats, Wistar ; X-Ray Microtomography |
| مستخلص: | There are a few data relating to the effects of lead (Pb) exposure on the alveolar bone, which has very distinct morphophysiological characteristics and is of great importance in the oral cavity. In this context, the aim of this study was to investigate the changes promoted after long-term exposure to Pb in the microstructure of the alveolar bone of rats. Twenty adult Wistar rats were exposed to 50 mg/kg/day of lead acetate for 55 days. These animals were euthanized and had their mandible removed. Each mandible was divided into hemimandibles, and the alveolar bone was used for bone lead quantification, crystallinity analysis, microstructure evaluation by the percentage of bone volume (BV/TV), number of trabeculae (Tb.N), thickness of the trabecular (Tb.Th), and trabecular space (Tb.Sp). Morphometric analysis of the exposed root area was also performed. Long-term exposure to Pb resulted in high levels of Pb in the alveolar bone but showed no changes in the organization of crystallinity. The microstructural analyses showed a reduction of BV/TV, Tb.Th, and Tb.N and increase of Tb.Sp parameters, resulting in an increase in the exposed root area and an alveolar bone loss in height. The findings of this study reveal the ability of Pb to alter the alveolar bone microstructure after long-term exposure to the metal, possibly due to changes in tissue homeostasis, contributing to the reduction of bone quality. (© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.) |
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| فهرسة مساهمة: | Keywords: Alveolar bone loss; Environmental exposure; Lead; MicroCT; Periodontium; Toxicology |
| المشرفين على المادة: | 0 (Acetates) 2P299V784P (Lead) |
| تواريخ الأحداث: | Date Created: 20211002 Date Completed: 20220204 Latest Revision: 20220204 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1007/s11356-021-16723-z |
| PMID: | 34599710 |
| قاعدة البيانات: | MEDLINE |
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