دورية أكاديمية
Von Willebrand Factor Multimeric Assay in Acquired von Willebrand Disease Diagnosis: A Report of Experience from North Estonia Medical Centre.
| العنوان: | Von Willebrand Factor Multimeric Assay in Acquired von Willebrand Disease Diagnosis: A Report of Experience from North Estonia Medical Centre. |
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| المؤلفون: | Pikta M; Department of Health Technologies, Tallinn University of Technology, Tallinn, Estonia.; Department of Laboratory Medicine, North Estonia Medical Centre, Tallinn, Estonia., Banys V; Department of Physiology, Biochemistry, Microbiology and Laboratory Medicine, Faculty of Medicine, Institute of Biomedical Sciences, Vilnius University, Vilnius, Lithuania., Szanto T; Research Program Unit of Systems Oncology, Helsinki University Hospital, Unit of Coagulation Disorders, Helsinki, Finland., Joutsi-Korhonen L; Department of Clinical Chemistry, Unit of Coagulation Disorders, HUSLAB Laboratory Services, Helsinki University Hospital and University of Helsinki, Helsinki, Finland., Vaide I; Hemato-Oncology Clinic, Institute of Clinical Medicine, Tartu University, Tartu, Estonia., Varik M; Hematology Department, North Estonia Medical Centre, Tallinn, Estonia., Lehtinen AE; Department of Hematology, Unit of Coagulation Disorders, Helsinki University Hospital Comprehensive Cancer Center and University of Helsinki, Helsinki, Finland., Giangrande P; Green Templeton College, University of Oxford, Oxford, United Kingdom., Laane E; Hemato-Oncology Clinic, Institute of Clinical Medicine, Tartu University, Tartu, Estonia. |
| المصدر: | Journal of laboratory physicians [J Lab Physicians] 2021 Sep; Vol. 13 (3), pp. 195-201. Date of Electronic Publication: 2021 Jun 28. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Thieme Country of Publication: Germany NLM ID: 101551511 Publication Model: Print-Electronic Cited Medium: Print ISSN: 0974-2727 (Print) Linking ISSN: 09742727 NLM ISO Abbreviation: J Lab Physicians Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2020- : [Stuttgart] : Thieme Original Publication: Mumbai : Medknow Publications |
| مستخلص: | Objectives Acquired von Willebrand syndrome (AVWS) is a rare and frequently underdiagnosed bleeding disorder with an unknown prevalence. The diagnosis of AVWS is made based on laboratory investigations and the presence of clinical symptoms. Evaluation and management of affected patients are complex due to the need for multiple laboratory assays. Materials and Methods Here, we describe the clinical and laboratory data of seven patients with a diagnosis of AVWS. All patients met the criteria for AVWS based on laboratory findings, bleeding symptoms, and the absence of any previous history of a bleeding disorder. Results In all cases, the laboratory findings, lack of bleeding anamnesis, and family history suggested the presence of AVWS. Von Willebrand factor multimeric analysis showed decreased high-molecular weight (HMW) multimers in six cases. Patients with lower HMW multimers experienced more severe bleeding complications. Conclusions The diagnosis of AVWS is complex and requires extensive laboratory evaluation. Interdisciplinary collaboration and complex laboratory evaluations are of paramount importance for the early recognition of AVWS and optimal AVWS diagnosis as well as successful clinical management. Competing Interests: Conflicts of Interests None declared. (The Indian Association of Laboratory Physicians. This is an open access article published by Thieme under the terms of the Creative Commons Attribution-NonDerivative-NonCommercial-License, permitting copying and reproduction so long as the original work is given appropriate credit. Contents may not be used for commercial purposes, or adapted, remixed, transformed or built upon. (https://creativecommons.org/licenses/by-nc-nd/4.0/).) |
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| فهرسة مساهمة: | Keywords: acquired von Willebrand syndrome; von Willebrand factor; von Willebrand factor multimers |
| تواريخ الأحداث: | Date Created: 20211004 Latest Revision: 20211005 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8478502 |
| DOI: | 10.1055/s-0041-1730818 |
| PMID: | 34602781 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 0974-2727 |
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| DOI: | 10.1055/s-0041-1730818 |