دورية أكاديمية
Label-free detection of virus-like particles employing rotationally symmetric nanowire array based whispering gallery and quasi-whispering gallery resonant modes onto a silicon platform.
| العنوان: | Label-free detection of virus-like particles employing rotationally symmetric nanowire array based whispering gallery and quasi-whispering gallery resonant modes onto a silicon platform. |
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| المؤلفون: | Hassan MM, Baten MZ |
| المصدر: | Optics express [Opt Express] 2021 Aug 02; Vol. 29 (16), pp. 25745-25761. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Optica Publishing Group Country of Publication: United States NLM ID: 101137103 Publication Model: Print Cited Medium: Internet ISSN: 1094-4087 (Electronic) Linking ISSN: 10944087 NLM ISO Abbreviation: Opt Express Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Washington, DC : Optica Publishing Group Original Publication: Washington, DC : Optical Society of America, 1997- |
| مواضيع طبية MeSH: | Models, Theoretical* , Nanowires* , Optical Devices* , Silicon*, Virion/*isolation & purification, Optics and Photonics/methods ; Signal-To-Noise Ratio ; Virion/ultrastructure |
| مستخلص: | In spite of tremendous advancements in modern diagnostics, there is a dire need for reliable, label-free detection of highly contagious pathogens like viruses. In view of the limitations of existing diagnostic techniques, the present theoretical study proposes a novel scheme of detecting virus-like particles employing whispering gallery and quasi-whispering gallery resonant modes of a composite optical system. Whereas whispering gallery mode (WGM) resonators are conventionally realized using micro-disk, -ring, -toroid or spherical structures, the present study utilizes a rotationally symmetric array of silicon nanowires which offers higher sensitivity compared to the conventional WGM resonator while detecting virus-like particles. Notwithstanding the relatively low quality factor of the system, the underlying multiple-scattering mediated photon entrapment, coupled with peripheral total-internal reflection, results in high fidelity of the system against low signal-to-noise ratio. Finite difference time domain based numerical analysis has been performed to correlate resonant modes of the array with spatial location of the virus. The correlation has been subsequently utilized for statistical analysis of simulated test cases. Assuming detection to be limited by resolution of the measurement system, results of the analysis suggest that for only about 5% of the simulate test cases the resonant wavelength shift lies within the minimum detection range of 0.001-0.01 nm. For a single virus of 160 nm diameter, more than 8 nm shift of the resonant mode and nearly 100% change of quality factor are attained with the proposed nanowire array based photonic structure. |
| المشرفين على المادة: | Z4152N8IUI (Silicon) |
| تواريخ الأحداث: | Date Created: 20211007 Date Completed: 20220117 Latest Revision: 20220117 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1364/OE.432064 |
| PMID: | 34614897 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1094-4087 |
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| DOI: | 10.1364/OE.432064 |