دورية أكاديمية
Role of serological rapid antibody test in the management of possible COVID-19 cases.
| العنوان: | Role of serological rapid antibody test in the management of possible COVID-19 cases. |
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| المؤلفون: | Yıldırım F; Department of Pulmonary and Critical Care Medicine, University of Health Sciences Diskapi Yildirim Beyazit Research and Education Hospital, Ankara 06110, Turkey., Gulhan PY; Department of Pulmonary Medicine, Düzce University, Faculty of Medicine, Düzce 81100, Turkey., Diken ÖE; Department of Chest Diseases, Adana Research and Education Hospital, University of Health Sciences, Adana 01230, Turkey., Capraz A; Department of Pulmonary Medicine, Amasya University Sabuncuoglu Serefeddin Research and Education Hospital, Amasya 05200, Turkey., Simsek M; Medical Intensive Care Unit, University of Health Sciences Diskapi Yildirim Beyazit Research and Education Hospital, Ankara 06110, Turkey., Yildirim BB; Department of Pulmonology, Research and Education Hospital of Baskent University, Konya 42030, Turkey., Taysi MR; Department of Infectious and Clinical Microbiology, University of Health Sciences Diskapi Yildirim Beyazit Research and Education Hospital, Ankara 06110, Turkey., Ozturk SY; Department of Pulmonary Medicine, Vezirkopru State Hospital, Samsun 55090, Turkey., Demirtas N; Department of Pulmonary Medicine, Kumluca State Hospital, Antalya 07070, Turkey., Ergil J; Department of Anaesthesiology and Reanimation, Diskapi Yildirim Beyazit Research and Education Hospital, University of Health Sciences, Ankara 06110, Turkey., Dirican A; Department of Pulmonary Medicine, Samsun Medicalpark Hospital, Samsun 55090, Turkey., Uzar T; Medical Student/Intern, Bahcesehir University Faculty of Medicine, Istanbul 34734, Turkey., Karaman I; Medical Student/Intern, Bahcesehir University Faculty of Medicine, Istanbul 34734, Turkey., Ozkaya S; Department of Pulmonary Medicine, Bahcesehir University, Faculty of Medicine, Istanbul 34734, Turkey. ozkayasevket@yahoo.com. |
| المصدر: | World journal of experimental medicine [World J Exp Med] 2021 Sep 20; Vol. 11 (4), pp. 44-54. Date of Electronic Publication: 2021 Sep 20 (Print Publication: 2021). |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Baishideng Publishing Group Country of Publication: United States NLM ID: 101618808 Publication Model: eCollection Cited Medium: Print ISSN: 2220-315X (Print) Linking ISSN: 2220315X NLM ISO Abbreviation: World J Exp Med Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Publication: 2014-: Pleasanton, CA : Baishideng Publishing Group Original Publication: Hong Kong, China : Baishideng Publishing Group Co., Limited |
| مستخلص: | Background: Although the detection of viral particles by reverse transcription polymerase chain reaction (RT-PCR) is the gold standard diagnostic test for coronavirus disease 2019 (COVID-19), the false-negative results constitute a big challenge. Aim: To examine a group of patients diagnosed and treated as possible COVID-19 pneumonia whose multiple nasopharyngeal swab samples were negative for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by RT-PCR but then serological immunoglobulin M/immunoglobulin G (IgM/IgG) antibody against SARS-CoV-2 were detected by rapid antibody test. Methods: Eighty possible COVID-19 patients who had at least two negative consecutive COVID-19 RT-PCR test and were subjected to serological rapid antibody test were evaluated in this study. Results: The specific serological total IgM/IgG antibody against SARS-CoV-2 was detected in twenty-two patients. The mean age of this patient group was 63.2± 13.1-years-old with a male/female ratio of 11/11. Cough was the most common symptom (90.9%). The most common presenting chest computed tomography findings were bilateral ground glass opacities (77.2%) and alveolar consolidations (50.1%). The mean duration of time from appearance of first symptoms to hospital admission, to hospital admission, to treatment duration and to serological positivity were 8.6 d, 11.2 d, 7.9 d, and 24 d, respectively. Compared with reference laboratory values, serologically positive patients have shown increased levels of acute phase reactants, such as C-reactive protein, ferritin, and procalcitonin and higher inflammatory markers, such as erythrocyte sedimentation rate, lactate dehydrogenase enzyme, and fibrin end-products, such as D-dimer. A left shift on white blood cell differential was observed with increased neutrophil counts and decreased lymphocytes. Conclusion: Our study demonstrated the feasibility of a COVID-19 diagnosis based on rapid antibody test in the cases of patients whose RT-PCR samples were negative. Detection of antibodies against SARS-CoV-2 with rapid antibody test should be included in the diagnostic algorithm in patients with possible COVID-19 pneumonia. Competing Interests: Conflict-of-interest statement: All authors have contributed significantly, and that all authors are in agreement with the content and honesty of the manuscript. All authors declare that they have no conflict of interest. (©The Author(s) 2021. Published by Baishideng Publishing Group Inc. All rights reserved.) |
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| فهرسة مساهمة: | Keywords: COVID-19; High resolution computed tomography; Pneumonia; Rapid antibody test; Reverse transcription polymerase chain reaction; Serology |
| تواريخ الأحداث: | Date Created: 20211007 Latest Revision: 20211008 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8462010 |
| DOI: | 10.5493/wjem.v11.i4.44 |
| PMID: | 34616666 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 2220-315X |
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| DOI: | 10.5493/wjem.v11.i4.44 |