دورية أكاديمية
Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma.
| العنوان: | Eosinophilic endotype of chronic obstructive pulmonary disease: similarities and differences from asthma. |
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| المؤلفون: | Li A; Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Chan HP; Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore., Gan PXL; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.; Singapore-HUJ Alliance for Research and Enterprise, National University of Singapore, Singapore., Liew MF; Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore.; FAST and Chronic Programmes, Alexandra Hospital, National University Health System, Singapore., Wong WSF; Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.; Singapore-HUJ Alliance for Research and Enterprise, National University of Singapore, Singapore., Lim HF; Division of Respiratory and Critical Care Medicine, Department of Medicine, National University Hospital, National University Health System, Singapore.; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. |
| المصدر: | The Korean journal of internal medicine [Korean J Intern Med] 2021 Nov; Vol. 36 (6), pp. 1305-1319. Date of Electronic Publication: 2021 Oct 12. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Association of Internal Medicine Country of Publication: Korea (South) NLM ID: 8712418 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 2005-6648 (Electronic) Linking ISSN: 12263303 NLM ISO Abbreviation: Korean J Intern Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: [Seoul] : Korean Association of Internal Medicine |
| مواضيع طبية MeSH: | Asthma*/diagnosis , Asthma*/drug therapy , Pulmonary Disease, Chronic Obstructive*/diagnosis , Pulmonary Disease, Chronic Obstructive*/drug therapy, Adrenal Cortex Hormones/therapeutic use ; Eosinophils ; Forced Expiratory Volume ; Humans ; Leukocyte Count ; Sputum |
| مستخلص: | Approximately 25% to 40% of patients with chronic obstructive pulmonary disease (COPD) have the eosinophilic endotype. It is important to identify this group accurately because they are more symptomatic and are at increased risk for exacerbations and accelerated decline in forced expiratory volume in the 1st second. Importantly, this endotype is a marker of treat ment responsiveness to inhaled corticosteroid (ICS), resulting in decreased mortality risk. In this review, we highlight differences in the biology of eosinophils in COPD compared to asthma and the different definitions of the COPD eosinophilic endotype based on sputum and blood eosinophil count (BEC) with the corresponding limitations. Although BEC is useful as a biomarker for eosinophilic COPD endotype, optimal BEC cut-offs can be combined with clinical characteristics to improve its sensitivity and specificity. A targeted approach comprising airway eosinophilia and appropriate clinical and physiological features may improve identification of subgroups of patients who would benefit from biologic therapy or early use of ICS for disease modification. |
| References: | N Engl J Med. 2010 Sep 16;363(12):1128-38. (PMID: 20843247) N Engl J Med. 2009 Mar 5;360(10):973-84. (PMID: 19264686) Am J Respir Crit Care Med. 1998 Nov;158(5 Pt 1):1511-7. (PMID: 9817701) Allergy Asthma Immunol Res. 2010 Apr;2(2):87-101. (PMID: 20358022) Chest. 2019 Sep;156(3):456-465. (PMID: 31047957) Am J Respir Crit Care Med. 2018 May 1;197(9):1223-1226. (PMID: 29099609) Front Immunol. 2012 Aug 28;3:270. (PMID: 22973272) Front Immunol. 2017 Dec 11;8:1781. (PMID: 29321780) Am J Respir Crit Care Med. 2018 Aug 1;198(3):329-339. (PMID: 29779416) N Engl J Med. 2017 Jun 22;376(25):2448-2458. (PMID: 28530840) Lancet Respir Med. 2016 May;4(5):390-8. (PMID: 27066739) Int J Chron Obstruct Pulmon Dis. 2012;7:587-95. (PMID: 23055709) Eur Respir J. 2017 Nov 22;50(5):. (PMID: 29167301) N Engl J Med. 2019 Sep 12;381(11):1023-1034. (PMID: 31112385) Respirology. 2021 Jan;26(1):52-61. (PMID: 32428971) Lancet Respir Med. 2015 Jun;3(6):435-42. (PMID: 25878028) Eur Respir J. 2014 Dec;44(6):1697-700. (PMID: 25323230) Eur Respir J. 2019 May 30;53(5):. (PMID: 30728205) Lancet Respir Med. 2017 May;5(5):390-400. (PMID: 28395936) Lancet. 2017 Sep 2;390(10098):980-987. (PMID: 28872030) Eur Respir J. 2016 May;47(5):1562-4. (PMID: 26846827) Lancet Respir Med. 2019 Sep;7(9):745-756. (PMID: 31281061) Am J Respir Crit Care Med. 2016 May 1;193(9):937-8. (PMID: 27128699) J Allergy Clin Immunol. 2015 Jan;135(1):63-72. (PMID: 25129678) Eur Respir J. 2018 Apr 19;51(4):. (PMID: 29563173) Respir Med. 2001 Dec;95(12):999-1002. (PMID: 11778799) Am J Respir Crit Care Med. 1999 Nov;160(5 Pt 2):S53-7. (PMID: 10556171) N Engl J Med. 2018 May 03;378(18):1671-1680. (PMID: 29668352) Am J Respir Crit Care Med. 2012 Jul 1;186(1):48-55. (PMID: 22447964) Lancet Respir Med. 2020 Feb;8(2):158-170. (PMID: 31575508) Respirology. 2020 Mar;25(3):259-266. (PMID: 31385389) Eur Respir J. 2017 Jul 20;50(1):. (PMID: 28729477) Eur Respir J. 2018 Dec 13;52(6):. (PMID: 30190269) Mediators Inflamm. 2015;2015:879783. (PMID: 25878402) Lancet Respir Med. 2017 Dec;5(12):956-967. (PMID: 29146301) J Allergy Clin Immunol. 2019 Jul;144(1):1-12. (PMID: 31277742) Viral Immunol. 2019 Jun;32(5):198-207. (PMID: 31140942) Int J Chron Obstruct Pulmon Dis. 2016 Jul 01;11:1495-504. (PMID: 27445469) Ther Adv Chronic Dis. 2016 Jan;7(1):34-51. (PMID: 26770668) Int J Chron Obstruct Pulmon Dis. 2020 Apr 20;15:821-829. (PMID: 32368028) Respirology. 2020 Aug;25(8):836-849. (PMID: 32064708) N Engl J Med. 1999 Jun 24;340(25):1941-7. (PMID: 10379017) Am J Respir Crit Care Med. 1998 Sep;158(3):723-7. (PMID: 9730996) ERJ Open Res. 2020 May 11;6(2):. (PMID: 32420313) Life Sci. 2019 Sep 15;233:116671. (PMID: 31336122) Thorax. 2013 Nov;68(11):1029-36. (PMID: 24130228) Am J Respir Crit Care Med. 2017 Dec 1;196(11):1385-1395. (PMID: 28862877) Respirology. 2019 Aug;24(8):765-776. (PMID: 30897284) Scand J Immunol. 2016 Aug;84(2):75-85. (PMID: 27167590) Eur Respir J. 2015 Sep;46(3):671-9. (PMID: 26113674) J Clin Invest. 2018 Mar 1;128(3):997-1009. (PMID: 29400693) Int J Chron Obstruct Pulmon Dis. 2006;1(1):39-47. (PMID: 18046901) Asthma Res Pract. 2017 Jan 6;3:1. (PMID: 28078100) Front Med (Lausanne). 2017 Jun 30;4:93. (PMID: 28713812) Semin Respir Crit Care Med. 2018 Feb;39(1):56-63. (PMID: 29427986) N Engl J Med. 2020 Jul 2;383(1):35-48. (PMID: 32579807) Thorax. 2012 Mar;67(3):199-208. (PMID: 20937641) Thorax. 2009 Aug;64(8):728-35. (PMID: 19638566) Lancet. 2012 Aug 18;380(9842):651-9. (PMID: 22901886) Eur Respir J. 2009 Oct;34(4):812-8. (PMID: 19357143) Respir Res. 2017 May 8;18(1):88. (PMID: 28482840) Lancet Respir Med. 2016 Jun;4(6):454-62. (PMID: 27061878) Am J Respir Crit Care Med. 2011 Sep 15;184(6):662-71. (PMID: 21680942) J Asthma. 2016 Dec;53(10):1026-32. (PMID: 27366830) Lancet Respir Med. 2017 Sep;5(9):691-706. (PMID: 28822787) Clin Exp Allergy. 2017 Nov;47(11):1374-1382. (PMID: 28658564) Lancet Respir Med. 2016 Sep;4(9):731-741. (PMID: 27460163) Lancet. 2016 Sep 3;388(10048):963-73. (PMID: 27598678) Am J Respir Crit Care Med. 2017 May 15;195(10):1402-1404. (PMID: 28165763) J Allergy Clin Immunol. 2017 Oct;140(4):1181-1184.e7. (PMID: 28506852) Lancet. 2016 Oct 29;388(10056):2115-2127. (PMID: 27609408) Chest. 2019 Jul;156(1):92-100. (PMID: 30978330) Lancet. 2017 May 13;389(10082):1919-1929. (PMID: 28385353) Can Respir J. 2013 Nov-Dec;20(6):415-6. (PMID: 24324980) Eur Respir J. 2018 May 24;51(5):. (PMID: 29650563) Front Immunol. 2018 Sep 28;9:2220. (PMID: 30323811) Lancet. 2000 Oct 28;356(9240):1480-5. (PMID: 11081531) Respir Med. 2001 Feb;95(2):115-21. (PMID: 11217907) Lancet. 2016 Oct 29;388(10056):2128-2141. (PMID: 27609406) Int J Chron Obstruct Pulmon Dis. 2016 Jun 16;11:1297-306. (PMID: 27366057) N Engl J Med. 1999 Jun 24;340(25):1948-53. (PMID: 10379018) Inflammation. 2013 Oct;36(5):1178-85. (PMID: 23681903) Biochem Pharmacol. 2020 Sep;179:113963. (PMID: 32278006) Eur Respir J. 2019 Jul 18;54(1):. (PMID: 31000678) Am J Respir Crit Care Med. 2016 May 1;193(9):965-74. (PMID: 26641631) Lancet Respir Med. 2018 Oct;6(10):747-758. (PMID: 30232048) Lancet Respir Med. 2018 Feb;6(2):117-126. (PMID: 29331313) Chest. 2003 Mar;123(3):778-83. (PMID: 12628878) Clinicoecon Outcomes Res. 2013 Jun 17;5:235-45. (PMID: 23818799) Drug Des Devel Ther. 2017 Oct 30;11:3137-3144. (PMID: 29133975) Lancet. 2018 Mar 17;391(10125):1076-1084. (PMID: 29429593) N Engl J Med. 2017 Oct 26;377(17):1613-1629. (PMID: 28893134) COPD. 2018 Jun-Aug;15(4):377-391. (PMID: 30067401) Clin Respir J. 2013 Jan;7(1):101-9. (PMID: 22452898) Glob Health Epidemiol Genom. 2018 Apr 6;3:e4. (PMID: 29868229) |
| معلومات مُعتمدة: | NUHSRO/2020/044/T1/1 National University of Singapore |
| فهرسة مساهمة: | Keywords: Eosinophilia; Inhaled corticosteroids; Pulmonary disease, chronic obstructive |
| المشرفين على المادة: | 0 (Adrenal Cortex Hormones) |
| تواريخ الأحداث: | Date Created: 20211012 Date Completed: 20211115 Latest Revision: 20211119 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8588979 |
| DOI: | 10.3904/kjim.2021.180 |
| PMID: | 34634855 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2005-6648 |
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| DOI: | 10.3904/kjim.2021.180 |