دورية أكاديمية
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Volunteer Recovery Support for Adolescents: Using propensity score based methods to understand dosage effects within a randomized controlled trial.

التفاصيل البيبلوغرافية
العنوان: Volunteer Recovery Support for Adolescents: Using propensity score based methods to understand dosage effects within a randomized controlled trial.
المؤلفون: Godley MD; Chestnut Health Systems, 448 Wylie Drive, Normal, IL 61761, USA. Electronic address: mgodley@chestnut.org., Passetti LL; Chestnut Health Systems, 448 Wylie Drive, Normal, IL 61761, USA. Electronic address: lpassetti@chestnut.org., Hunter BD; Chestnut Health Systems, 448 Wylie Drive, Normal, IL 61761, USA. Electronic address: bdhunter@chestnut.org., Griffin BA; RAND Corporation, 1200 South Hayes Street, Arlington, VA 22202, USA. Electronic address: bethg@rand.org.
المصدر: Journal of substance abuse treatment [J Subst Abuse Treat] 2022 Jan; Vol. 132, pp. 108637. Date of Electronic Publication: 2021 Oct 08.
نوع المنشور: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural
اللغة: English
بيانات الدورية: Publisher: Pergamon Press Country of Publication: United States NLM ID: 8500909 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-6483 (Electronic) Linking ISSN: 07405472 NLM ISO Abbreviation: J Subst Abuse Treat Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York : Pergamon Press, c1984-
مواضيع طبية MeSH: Substance-Related Disorders*/therapy, Adolescent ; Humans ; Patient Compliance ; Propensity Score ; Telephone ; Volunteers
مستخلص: Background: In a recently published randomized controlled trial (RCT) of Volunteer Recovery Support for Adolescents (VRSA), a secondary finding indicated that better adherence to planned VRSA telephone session frequency resulted in significantly higher remission rates relative to lower session adherence. However, interpretation of this dose-response relationship may have been confounded by participant characteristics such as baseline levels of substance use and mental health problems.
Methods: The present study used statistical methods designed to approximate RCTs when comparing more than two nonequivalent groups that include an assessment of the potential impact of omitted variables. Classification and Regression Tree (CRT) analysis was used to establish the cut-point between high (H) and low (L) VRSA dosage groups. Because we were interested in generalizing to youth with poor attendance, the L-VRSA group served as the reference group. Balancing weights for H-VRSA and a services as usual (SAU) control group were calculated to ensure similarity of baseline pretreatment characteristics to the reference group, and sensitivity of findings to unobserved confounding variables was assessed.
Results: Findings suggested that superior remission rates at the end of the intervention phase were the result of high adherence to planned VRSA session frequency. Recommendations to achieve high VRSA participation among a larger segment of youth and to test whether longer VRSA duration improves the stability of recovery outcomes are provided.
Conclusion: Few published dose-response studies have adequately controlled for selection confounds from both observed and unobserved confounding. As such, the present study aims to both assess the impact of different dosage levels of VRSA and provide a template for how to apply state-of-the-art statistical methods designed to approximate randomized controlled trials to such studies.
(Copyright © 2021 Elsevier Inc. All rights reserved.)
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معلومات مُعتمدة: R01 AA021118 United States AA NIAAA NIH HHS; R01 DA045049 United States DA NIDA NIH HHS
فهرسة مساهمة: Keywords: Adolescent; Causal inference; Omitted variable; Propensity scores; Recovery support; Substance use disorder
تواريخ الأحداث: Date Created: 20211016 Date Completed: 20220321 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8671322
DOI: 10.1016/j.jsat.2021.108637
PMID: 34654584
قاعدة البيانات: MEDLINE
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