دورية أكاديمية
Stimuli-Responsive Amphiphilic Pillar[ n ]arene Nanovesicles for Targeted Delivery of Cancer Drugs.
| العنوان: | Stimuli-Responsive Amphiphilic Pillar[ n ]arene Nanovesicles for Targeted Delivery of Cancer Drugs. |
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| المؤلفون: | Fahmy SA; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, New Cairo 11835, Egypt.; School of Life and Medical Sciences, University of Hertfordshire Hosted by Global Academic Foundation, R5 New Garden City, New Capital, Cairo 11835, Egypt., Ramzy A; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, New Cairo 11835, Egypt., Saleh BM; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, New Cairo 11835, Egypt., El-Said Azzazy HM; Department of Chemistry, School of Sciences & Engineering, The American University in Cairo, AUC Avenue, New Cairo 11835, Egypt. |
| المصدر: | ACS omega [ACS Omega] 2021 Sep 30; Vol. 6 (40), pp. 25876-25883. Date of Electronic Publication: 2021 Sep 30 (Print Publication: 2021). |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Washington, D.C. : American Chemical Society, [2016]- |
| مستخلص: | Cancer chemotherapeutics face several challenges, including uncontrollable drug release, off-target toxic effects, and poor bioavailability. Recently, supramolecular nanovesicles, such as calix[ n ]arenes (CXs), cyclodextrins (CDs), cucurbiturils (CBs), and pillar[ n ]arenes (PRs), have attracted attention as potential smart nanocarriers for chemotherapeutics because of their exceptional cavities that can achieve high encapsulation capacity and accommodate both hydrophilic and hydrophobic drugs. In addition, they can be functionalized with different stimuli-responsive groups, which facilitate controlled drug release. Supramolecular nanovesicles, loaded with drugs and decorated with stimuli-responsive targeting moieties, are designed by either host-guest complexation or self-assembly of amphiphilic cavitands. Pillar[ n ]arenes, in particular, are novel supramolecular host molecules that have recently been employed in cancer targeted drug delivery because of their symmetric pillar-shaped structure, simplicity of functionalization, and biocompatibility. This review summarizes state-of-the-art strategies for developing single or multiple stimuli-responsive pillar[ n ]arene nanovesicles for effective cancer treatment. Competing Interests: The authors declare no competing financial interest. (© 2021 The Authors. Published by American Chemical Society.) |
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| تواريخ الأحداث: | Date Created: 20211018 Latest Revision: 20240403 |
| رمز التحديث: | 20240403 |
| مُعرف محوري في PubMed: | PMC8515365 |
| DOI: | 10.1021/acsomega.1c04297 |
| PMID: | 34660950 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 2470-1343 |
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| DOI: | 10.1021/acsomega.1c04297 |