دورية أكاديمية
Serine/threonine kinase inhibition as antifibrotic therapy: transforming growth factor-β and Rho kinase inhibitors.
| العنوان: | Serine/threonine kinase inhibition as antifibrotic therapy: transforming growth factor-β and Rho kinase inhibitors. |
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| المؤلفون: | Mendoza FA; Division of Rheumatology, Department of Medicine.; Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, USA., Jimenez SA; Jefferson Institute of Molecular Medicine and Scleroderma Center, Thomas Jefferson University, Philadelphia, PA, USA. |
| المصدر: | Rheumatology (Oxford, England) [Rheumatology (Oxford)] 2022 Apr 11; Vol. 61 (4), pp. 1354-1365. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Oxford University Press Country of Publication: England NLM ID: 100883501 Publication Model: Print Cited Medium: Internet ISSN: 1462-0332 (Electronic) Linking ISSN: 14620324 NLM ISO Abbreviation: Rheumatology (Oxford) Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Oxford, UK : Avenel, N.J. : Oxford University Press ; Distributed by Mercury International, c1999- |
| مواضيع طبية MeSH: | Protein Serine-Threonine Kinases* , Transforming Growth Factor beta*/metabolism, Fibrosis ; Humans ; Phosphorylation ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use ; Serine/metabolism ; Threonine/metabolism ; Transforming Growth Factors/metabolism ; rho-Associated Kinases/metabolism |
| مستخلص: | Serine/threonine kinases mediate the phosphorylation of intracellular protein targets, transferring a phosphorus group from an adenosine triphosphate molecule to the specific amino acid residues within the target proteins. Serine/threonine kinases regulate multiple key cellular functions. From this large group of kinases, TGF-β through serine/threonine activity of its receptors and Rho kinase (ROCK) play an important role in the development and maintenance of fibrosis in various human diseases, including SSc. In recent years, multiple drugs targeting and inhibiting these kinases have been developed, opening the possibility of becoming potential antifibrotic agents of clinical value for treating fibrotic diseases. This review analyses the contribution of TGF-β and ROCK-mediated serine/threonine kinase molecular pathways to the development and maintenance of pathological fibrosis and the potential clinical use of their inhibition. (© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissions@oup.com.) |
| فهرسة مساهمة: | Keywords: ROCK; ROCK inhibitors; TGF-β; antifibrotic treatment; fibrosis; inhibitors; kinase inhibitors; serine/threonine kinase |
| المشرفين على المادة: | 0 (Protein Kinase Inhibitors) 0 (Transforming Growth Factor beta) 2ZD004190S (Threonine) 452VLY9402 (Serine) 76057-06-2 (Transforming Growth Factors) EC 2.7.11.1 (Protein Serine-Threonine Kinases) EC 2.7.11.1 (rho-Associated Kinases) |
| تواريخ الأحداث: | Date Created: 20211019 Date Completed: 20220413 Latest Revision: 20220525 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1093/rheumatology/keab762 |
| PMID: | 34664623 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 1462-0332 |
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| DOI: | 10.1093/rheumatology/keab762 |