دورية أكاديمية
Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks.
العنوان: | Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks. |
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المؤلفون: | Weissman JL; Department of Biological Sciences-Marine and Environmental Biology, University of Southern California, Los Angeles, CA, USA., Alseth EO; Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn Campus, Penryn, UK., Meaden S; Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn Campus, Penryn, UK., Westra ER; Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn Campus, Penryn, UK., Fuhrman JA; Department of Biological Sciences-Marine and Environmental Biology, University of Southern California, Los Angeles, CA, USA. |
المصدر: | Proceedings. Biological sciences [Proc Biol Sci] 2021 Oct 27; Vol. 288 (1961), pp. 20211555. Date of Electronic Publication: 2021 Oct 20. |
نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
اللغة: | English |
بيانات الدورية: | Publisher: Royal Society of London Country of Publication: England NLM ID: 101245157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2954 (Electronic) Linking ISSN: 09628452 NLM ISO Abbreviation: Proc Biol Sci Subsets: MEDLINE |
أسماء مطبوعة: | Original Publication: London : Royal Society of London, c1990- |
مواضيع طبية MeSH: | Bacteriophages* , Viruses*, Archaea ; Bacteria/genetics ; CRISPR-Cas Systems ; Disease Outbreaks |
مستخلص: | Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptive immune systems enable bacteria and archaea to efficiently respond to viral pathogens by creating a genomic record of previous encounters. These systems are broadly distributed across prokaryotic taxa, yet are surprisingly absent in a majority of organisms, suggesting that the benefits of adaptive immunity frequently do not outweigh the costs. Here, combining experiments and models, we show that a delayed immune response which allows viruses to transiently redirect cellular resources to reproduction, which we call 'immune lag', is extremely costly during viral outbreaks, even to completely immune hosts. Critically, the costs of lag are only revealed by examining the early, transient dynamics of a host-virus system occurring immediately after viral challenge. Lag is a basic parameter of microbial defence, relevant to all intracellular, post-infection antiviral defence systems, that has to-date been largely ignored by theoretical and experimental treatments of host-phage systems. |
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فهرسة مساهمة: | Keywords: CRISPR-Cas; adaptive immunity; bacteriophage; host–virus interactions |
سلسلة جزيئية: | figshare 10.6084/m9.figshare.c.5647985 |
تواريخ الأحداث: | Date Created: 20211020 Date Completed: 20220321 Latest Revision: 20220321 |
رمز التحديث: | 20231215 |
مُعرف محوري في PubMed: | PMC8527200 |
DOI: | 10.1098/rspb.2021.1555 |
PMID: | 34666523 |
قاعدة البيانات: | MEDLINE |
تدمد: | 1471-2954 |
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DOI: | 10.1098/rspb.2021.1555 |