دورية أكاديمية
أعرض في EDS

Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks.

التفاصيل البيبلوغرافية
العنوان: Immune lag is a major cost of prokaryotic adaptive immunity during viral outbreaks.
المؤلفون: Weissman JL; Department of Biological Sciences-Marine and Environmental Biology, University of Southern California, Los Angeles, CA, USA., Alseth EO; Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn Campus, Penryn, UK., Meaden S; Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn Campus, Penryn, UK., Westra ER; Environment and Sustainability Institute, Biosciences, University of Exeter, Penryn Campus, Penryn, UK., Fuhrman JA; Department of Biological Sciences-Marine and Environmental Biology, University of Southern California, Los Angeles, CA, USA.
المصدر: Proceedings. Biological sciences [Proc Biol Sci] 2021 Oct 27; Vol. 288 (1961), pp. 20211555. Date of Electronic Publication: 2021 Oct 20.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Royal Society of London Country of Publication: England NLM ID: 101245157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1471-2954 (Electronic) Linking ISSN: 09628452 NLM ISO Abbreviation: Proc Biol Sci Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Royal Society of London, c1990-
مواضيع طبية MeSH: Bacteriophages* , Viruses*, Archaea ; Bacteria/genetics ; CRISPR-Cas Systems ; Disease Outbreaks
مستخلص: Clustered regularly interspaced short palindromic repeat (CRISPR)-Cas adaptive immune systems enable bacteria and archaea to efficiently respond to viral pathogens by creating a genomic record of previous encounters. These systems are broadly distributed across prokaryotic taxa, yet are surprisingly absent in a majority of organisms, suggesting that the benefits of adaptive immunity frequently do not outweigh the costs. Here, combining experiments and models, we show that a delayed immune response which allows viruses to transiently redirect cellular resources to reproduction, which we call 'immune lag', is extremely costly during viral outbreaks, even to completely immune hosts. Critically, the costs of lag are only revealed by examining the early, transient dynamics of a host-virus system occurring immediately after viral challenge. Lag is a basic parameter of microbial defence, relevant to all intracellular, post-infection antiviral defence systems, that has to-date been largely ignored by theoretical and experimental treatments of host-phage systems.
References: Annu Rev Genet. 2020 Nov 23;54:93-120. (PMID: 32857635)
mBio. 2018 Nov 13;9(6):. (PMID: 30425154)
Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180095. (PMID: 30905281)
Science. 2007 Mar 23;315(5819):1709-12. (PMID: 17379808)
Nature. 2020 Feb;578(7793):149-153. (PMID: 31969710)
Proc Natl Acad Sci U S A. 2017 Jan 3;114(1):131-135. (PMID: 27849583)
Nature. 2019 Oct;574(7779):549-552. (PMID: 31645729)
PLoS One. 2012;7(4):e35888. (PMID: 22558257)
Nat Commun. 2016 Feb 03;7:10613. (PMID: 26837824)
Curr Protoc Microbiol. 2013 Feb;Chapter 9:Unit 9C.1. (PMID: 23408134)
Proc Biol Sci. 2016 Aug 31;283(1837):. (PMID: 27581884)
ISME J. 2016 Apr;10(4):858-70. (PMID: 26394009)
Nature. 2016 Apr 21;532(7599):385-8. (PMID: 27074511)
Mol Microbiol. 2002 Mar;43(6):1565-75. (PMID: 11952905)
Nat Methods. 2005 Sep;2(9):685-9. (PMID: 16118639)
Nat Microbiol. 2019 Jun;4(6):956-963. (PMID: 30886355)
Nature. 2017 Apr 6;544(7648):101-104. (PMID: 28355179)
Science. 2015 May 22;348(6237):1261498. (PMID: 25999515)
Nucleic Acids Res. 2014;42(16):10618-31. (PMID: 25120263)
Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20190101. (PMID: 30905294)
Curr Biol. 2015 Apr 20;25(8):1043-9. (PMID: 25772450)
BMC Evol Biol. 2017 Apr 4;17(1):94. (PMID: 28376755)
Curr Opin Microbiol. 2017 Jun;37:1-7. (PMID: 28359988)
Philos Trans R Soc Lond B Biol Sci. 2019 May 13;374(1772):20180088. (PMID: 30905287)
ISME J. 2021 Feb;15(2):534-544. (PMID: 33011743)
Cell. 2018 Mar 8;172(6):1239-1259. (PMID: 29522745)
ISME J. 2019 Oct;13(10):2589-2602. (PMID: 31239539)
Mol Microbiol. 2012 Sep;85(6):1057-71. (PMID: 22834929)
FEMS Microbiol Lett. 2019 Jun 1;366(11):. (PMID: 31226710)
Science. 2018 Mar 2;359(6379):. (PMID: 29371424)
Nat Rev Microbiol. 2020 Feb;18(2):113-119. (PMID: 31695182)
PLoS Comput Biol. 2017 Apr 17;13(4):e1005486. (PMID: 28414716)
Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10098-103. (PMID: 21646539)
Nat Commun. 2017 Dec 12;8(1):2094. (PMID: 29234047)
J Bacteriol. 2013 Sep;195(17):3834-44. (PMID: 23794616)
Nat Commun. 2013;4:1430. (PMID: 23385575)
ISME J. 2020 Apr;14(4):881-895. (PMID: 31896786)
Cell Host Microbe. 2019 Feb 13;25(2):242-249.e3. (PMID: 30709780)
Nature. 2015 Apr 23;520(7548):505-510. (PMID: 25874675)
mBio. 2012 Dec 04;3(6):e00456-12. (PMID: 23221803)
Curr Opin Infect Dis. 2015 Jun;28(3):267-74. (PMID: 25887612)
PLoS Genet. 2010 Oct 28;6(10):e1001171. (PMID: 21060859)
Mol Microbiol. 2000 Apr;36(1):244-6. (PMID: 10760181)
Mol Microbiol. 2014 Jun;92(5):1072-91. (PMID: 24720807)
Nat Microbiol. 2018 Jan;3(1):90-98. (PMID: 29085076)
Nat Commun. 2014 Jul 24;5:4399. (PMID: 25056268)
Res Microbiol. 2011 Jan;162(1):27-38. (PMID: 20863886)
Nat Rev Microbiol. 2019 Jan;17(1):7-12. (PMID: 30171202)
Proc Natl Acad Sci U S A. 2018 Aug 7;115(32):E7462-E7468. (PMID: 30038015)
ISME J. 2020 Mar;14(3):828-836. (PMID: 31896785)
RNA. 2008 Dec;14(12):2572-9. (PMID: 18971321)
EMBO J. 2015 Jan 13;34(2):169-83. (PMID: 25452498)
Nat Rev Microbiol. 2020 Feb;18(2):67-83. (PMID: 31857715)
PLoS Genet. 2013;9(3):e1003312. (PMID: 23516369)
Evolution. 2012 Jul;66(7):2015-29. (PMID: 22759281)
PLoS Genet. 2013;9(9):e1003844. (PMID: 24086164)
Biol Direct. 2006 Mar 16;1:7. (PMID: 16545108)
PLoS Comput Biol. 2012;8(4):e1002475. (PMID: 22532794)
Science. 2008 Aug 15;321(5891):960-4. (PMID: 18703739)
Mol Cell. 2016 Dec 15;64(6):1102-1108. (PMID: 27867010)
ISME J. 2018 Feb;12(2):585-597. (PMID: 29328063)
J Mol Evol. 2005 Feb;60(2):174-82. (PMID: 15791728)
PLoS One. 2014 Jul 07;9(7):e101710. (PMID: 25000306)
Genes Dev. 2008 Dec 15;22(24):3489-96. (PMID: 19141480)
Nat Commun. 2012 Jul 10;3:945. (PMID: 22781758)
Evolution. 2019 Dec;73(12):2461-2475. (PMID: 31433508)
Nucleic Acids Res. 2015 Jul 13;43(12):6038-48. (PMID: 26007654)
ISME J. 2020 Jun;14(6):1479-1493. (PMID: 32132663)
G3 (Bethesda). 2020 Mar 5;10(3):1039-1050. (PMID: 31937548)
Trends Genet. 2010 Aug;26(8):335-40. (PMID: 20598393)
فهرسة مساهمة: Keywords: CRISPR-Cas; adaptive immunity; bacteriophage; host–virus interactions
سلسلة جزيئية: figshare 10.6084/m9.figshare.c.5647985
تواريخ الأحداث: Date Created: 20211020 Date Completed: 20220321 Latest Revision: 20220321
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8527200
DOI: 10.1098/rspb.2021.1555
PMID: 34666523
قاعدة البيانات: MEDLINE
الوصف
تدمد:1471-2954
DOI:10.1098/rspb.2021.1555