دورية أكاديمية
The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis.
| العنوان: | The uncinate fasciculus in individuals with and at risk for bipolar disorder: A meta-analysis. |
|---|---|
| المؤلفون: | Xu E; Section on Mood Dysregulation and Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States., Nguyen L; Section on Mood Dysregulation and Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States., Hu R; Section on Mood Dysregulation and Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States., Stavish CM; Section on Mood Dysregulation and Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States., Leibenluft E; Section on Mood Dysregulation and Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States., Linke JO; Section on Mood Dysregulation and Neuroscience, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, United States. |
| المصدر: | Journal of affective disorders [J Affect Disord] 2022 Jan 15; Vol. 297, pp. 208-216. Date of Electronic Publication: 2021 Oct 24. |
| نوع المنشور: | Journal Article; Meta-Analysis; Research Support, N.I.H., Intramural; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier/North-Holland Biomedical Press Country of Publication: Netherlands NLM ID: 7906073 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1573-2517 (Electronic) Linking ISSN: 01650327 NLM ISO Abbreviation: J Affect Disord Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam, Elsevier/North-Holland Biomedical Press. |
| مواضيع طبية MeSH: | Bipolar Disorder*/diagnostic imaging , White Matter*/diagnostic imaging, Anisotropy ; Diffusion Tensor Imaging ; Humans ; Nerve Net ; Uncinate Fasciculus |
| مستخلص: | Background: Bipolar disorder (BD) is a severe mental disorder, characterized by prominent mood swings and emotion regulation (ER) deficits. The uncinate fasciculus (UF), a white matter tract connecting the amygdala and the ventral prefrontal cortex, has been implicated in ER. Aberrancies in UF microstructure may be an endophenotype associated with increased risk for BD. However, studies in individuals with BD and their first-degree relatives (REL) have yielded inconsistent findings. This meta-analysis takes a region-of-interest approach to consolidate the available evidence and elucidate the role of the UF in the risk-architecture of BD. Methods: Using web-based search engines, we identified diffusion tensor imaging (DTI) studies focusing on the left and right UF and conducted meta-analyses comparing fractional anisotropy (FA) and radial diffusivity (RD) between BD or REL and healthy control participants (HC). Results: We included 32 studies (n Conclusion: Our findings support aberrant UF microstructure, potentially related to alterations in myelination, as a mechanism, but not as an endophenotype of BD. However, given the limited power in the REL subsample, the latter finding must be considered preliminary. Studies examining the role of the UF in individuals at familial risk for BD are warranted. (Copyright © 2021. Published by Elsevier B.V.) |
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| معلومات مُعتمدة: | Z01 MH002778 United States ImNIH Intramural NIH HHS; ZIA MH002778 United States ImNIH Intramural NIH HHS |
| فهرسة مساهمة: | Keywords: At-risk relatives; Bipolar disorder; Endophenotype; Uncinate fasciculus; White matter |
| تواريخ الأحداث: | Date Created: 20211026 Date Completed: 20220125 Latest Revision: 20230116 |
| رمز التحديث: | 20240628 |
| مُعرف محوري في PubMed: | PMC8631233 |
| DOI: | 10.1016/j.jad.2021.10.045 |
| PMID: | 34699854 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1573-2517 |
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| DOI: | 10.1016/j.jad.2021.10.045 |