دورية أكاديمية
أعرض في EDS

Spatially patterned bi-electrode epiretinal stimulation for axon avoidance at cellular resolution.

التفاصيل البيبلوغرافية
العنوان: Spatially patterned bi-electrode epiretinal stimulation for axon avoidance at cellular resolution.
المؤلفون: Vilkhu RS; Department of Electrical Engineering, Stanford University, Stanford, CA, United States of America., Madugula SS; Departments of Neurosurgery, Ophthalmology, and Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Grosberg LE; Departments of Neurosurgery, Ophthalmology, and Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Gogliettino AR; Departments of Neurosurgery, Ophthalmology, and Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America., Hottowy P; Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow 30-059, Poland., Dabrowski W; Faculty of Physics and Applied Computer Science, AGH University of Science and Technology, Krakow 30-059, Poland., Sher A; Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, United States of America., Litke AM; Santa Cruz Institute for Particle Physics, University of California, Santa Cruz, CA, United States of America., Mitra S; Department of Electrical Engineering, Stanford University, Stanford, CA, United States of America., Chichilnisky EJ; Departments of Neurosurgery, Ophthalmology, and Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA, United States of America.
المصدر: Journal of neural engineering [J Neural Eng] 2021 Nov 15; Vol. 18 (6). Date of Electronic Publication: 2021 Nov 15.
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Institute of Physics Pub Country of Publication: England NLM ID: 101217933 Publication Model: Electronic Cited Medium: Internet ISSN: 1741-2552 (Electronic) Linking ISSN: 17412552 NLM ISO Abbreviation: J Neural Eng Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Bristol, U.K. : Institute of Physics Pub., 2004-
مواضيع طبية MeSH: Retinal Ganglion Cells*/physiology , Visual Prosthesis*, Action Potentials/physiology ; Axons/physiology ; Electric Stimulation ; Electrodes ; Humans ; Retina/physiology
مستخلص: Objective. Epiretinal prostheses are designed to restore vision to people blinded by photoreceptor degenerative diseases by stimulating surviving retinal ganglion cells (RGCs), which carry visual signals to the brain. However, inadvertent stimulation of RGCs at their axons can result in non-focal visual percepts, limiting the quality of artificial vision. Theoretical work has suggested that axon activation can be avoided with current stimulation designed to minimize the second spatial derivative of the induced extracellular voltage along the axon. However, this approach has not been verified experimentally at the resolution of single cells. Approach. In this work, a custom multi-electrode array (512 electrodes, 10 μ m diameter, 60 μ m pitch) was used to stimulate and record RGCs in macaque retina ex vivo at single-cell, single-spike resolution. RGC activation thresholds resulting from bi-electrode stimulation, which consisted of bipolar currents simultaneously delivered through two electrodes straddling an axon, were compared to activation thresholds from traditional single-electrode stimulation. Main results. On average, across three retinal preparations, the bi-electrode stimulation strategy reduced somatic activation thresholds (∼21%) while increasing axonal activation thresholds (∼14%), thus favoring selective somatic activation. Furthermore, individual examples revealed rescued selective activation of somas that was not possible with any individual electrode. Significance. This work suggests that a bi-electrode epiretinal stimulation strategy can reduce inadvertent axonal activation at cellular resolution, for high-fidelity artificial vision.
(© 2021 IOP Publishing Ltd.)
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معلومات مُعتمدة: F30 EY030776 United States EY NEI NIH HHS; P30 EY019005 United States EY NEI NIH HHS; P30 EY026877 United States EY NEI NIH HHS; R01 EY021271 United States EY NEI NIH HHS
فهرسة مساهمة: Keywords: axon activation; cellular resolution; epiretinal prosthesis; retinal electrophysiology; retinal ganglion cells; spatially-patterned stimulation strategy
تواريخ الأحداث: Date Created: 20211028 Date Completed: 20220307 Latest Revision: 20221116
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8736333
DOI: 10.1088/1741-2552/ac3450
PMID: 34710857
قاعدة البيانات: MEDLINE
الوصف
تدمد:1741-2552
DOI:10.1088/1741-2552/ac3450