دورية أكاديمية
Hydroalcoholic leaves extract of Vaccinium ashei Reade promotes cell cycle arrest and apoptosis on T-cell acute lymphoblastic leukemia.
| العنوان: | Hydroalcoholic leaves extract of Vaccinium ashei Reade promotes cell cycle arrest and apoptosis on T-cell acute lymphoblastic leukemia. |
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| المؤلفون: | Meneghetti D; Universidade Regional Integrada do Alto Uruguai e das Missões, Frederico Westphalen, RS, Brazil., Cezarotto VS; Universidade Regional Integrada do Alto Uruguai e das Missões, Frederico Westphalen, RS, Brazil., do Nascimento NP; Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Estadual de Campinas, Campinas, SP, Brazil.; Centro Infantil Boldrini, Campinas, SP, Brazil., Migita NA; Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Estadual de Campinas, Campinas, SP, Brazil.; Centro Infantil Boldrini, Campinas, SP, Brazil., Corrêa JR; Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Estadual de Campinas, Campinas, SP, Brazil.; Centro Infantil Boldrini, Campinas, SP, Brazil., Riccio MF; Centro Infantil Boldrini, Campinas, SP, Brazil., Zambaldi LG; Centro Infantil Boldrini, Campinas, SP, Brazil., Yunes JA; Centro Infantil Boldrini, Campinas, SP, Brazil.; Departamento de Genética Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brazil., Artico LL; Programa de Pós-graduação em Genética e Biologia Molecular, Universidade Estadual de Campinas, Campinas, SP, Brazil.; Centro Infantil Boldrini, Campinas, SP, Brazil. |
| المصدر: | Natural product research [Nat Prod Res] 2022 Sep; Vol. 36 (17), pp. 4520-4524. Date of Electronic Publication: 2021 Oct 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Taylor & Francis Health Sciences Country of Publication: England NLM ID: 101167924 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1478-6427 (Electronic) Linking ISSN: 14786419 NLM ISO Abbreviation: Nat Prod Res Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Milton Park, UK : Taylor & Francis Health Sciences, c2003- |
| مواضيع طبية MeSH: | Blueberry Plants*/chemistry , Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* , Vaccinium*/chemistry, Hydrocarbons/*pharmacology, Apoptosis ; Cell Cycle Checkpoints ; Humans ; Hydrocarbons/chemistry ; Phenols/analysis ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; T-Lymphocytes ; Tumor Suppressor Protein p53 |
| مستخلص: | Vaccinium ashei Reade, popularly known as Rabbiteye blueberry, has several therapeutic properties attributed to the phenolic compounds present in its leaves and fruits. Here, we sought to evaluate the effects of the hydroalcoholic extract from V. ashei leaves (Bluegem cultivar, VAB) in T-cell Acute lymphoblastic leukemia (T-ALL). The VAB extract was toxic to T-ALL cells at the ∼60 µg/ml concentration. T-ALL cell death occurred through apoptosis. VAB extract was found to induce micronuclei formation, p53 pathway activation, and cell cycle arrest. Those mutagenic effects were evidenced through microscopy analysis and molecular p53 pathway activation. A series of phenolic compounds were identified in VAB extract by mass spectrometry, such as vanillic acid, catechin, caffeic acid, chlorogenic acid, rutin, coumaric acid, taxifolin, quercetin and naringenin, some of which are presumed to induce DNA damage. In conclusion, the V. ashei leaves extract may have important secondary metabolites with antileukemic properties. |
| فهرسة مساهمة: | Keywords: Blueberry; mutagenesis; p53 pathway; phenolic compounds |
| المشرفين على المادة: | 0 (Hydrocarbons) 0 (Phenols) 0 (Plant Extracts) 0 (Tumor Suppressor Protein p53) |
| تواريخ الأحداث: | Date Created: 20211029 Date Completed: 20220907 Latest Revision: 20220908 |
| رمز التحديث: | 20221213 |
| DOI: | 10.1080/14786419.2021.1990281 |
| PMID: | 34711101 |
| قاعدة البيانات: | MEDLINE |
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