دورية أكاديمية
Tamm-Horsfall protein. Abnormal localization in renal disease.
| العنوان: | Tamm-Horsfall protein. Abnormal localization in renal disease. |
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| المؤلفون: | Resnick JS, Sisson S, Vernier RL |
| المصدر: | Laboratory investigation; a journal of technical methods and pathology [Lab Invest] 1978 May; Vol. 38 (5), pp. 550-5. |
| نوع المنشور: | Journal Article; Research Support, U.S. Gov't, P.H.S. |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Inc Country of Publication: United States NLM ID: 0376617 Publication Model: Print Cited Medium: Print ISSN: 0023-6837 (Print) Linking ISSN: 00236837 NLM ISO Abbreviation: Lab Invest Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2023- : [New York] : Elsevier Inc. Original Publication: Baltimore : Williams & Wilkins |
| مواضيع طبية MeSH: | Kidney Diseases/*metabolism , Mucoproteins/*analysis, Fluorescent Antibody Technique ; Histocytochemistry ; Humans ; Kidney/analysis ; Kidney/ultrastructure ; Kidney Diseases/pathology ; Prospective Studies ; Retrospective Studies |
| مستخلص: | Interstitial deposits of periodic acid-Schiff positive fibrillar material have been detected in a variety of diseases associated with tubulointerstitial pathology. This material has been shown to be Tamm-Horsfall protein by immunofluorescent, immunochemical, and electron microscopic studies. Prospective evaluation of 133 kidneys revealed deposits in 11 per cent. These deposits included medullary cystic disease (50 per cent), obstructive uropathy and vesicoureteral reflux (21 per cent), and tubulointerstitial disease (29 per cent). Tamm-Horsfall protein was also detected in Bowman's space in four cases of obstructive uropathy. It is proposed that these deposits result from severe tubular damage with release of Tamm-Horsfall protein from its normal intracellular and intralumenal locations into the renal interstitium. We speculate that the intersitial deposition of this sequestered protein may result in a continued inflammatory response and progressive renal damage. |
| المشرفين على المادة: | 0 (Mucoproteins) |
| تواريخ الأحداث: | Date Created: 19780501 Date Completed: 19780628 Latest Revision: 20061115 |
| رمز التحديث: | 20240829 |
| PMID: | 347168 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 0023-6837 |
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