دورية أكاديمية
أعرض في EDS

Low frequency of community-acquired bacterial co-infection in patients hospitalized for COVID-19 based on clinical, radiological and microbiological criteria: a retrospective cohort study.

التفاصيل البيبلوغرافية
العنوان: Low frequency of community-acquired bacterial co-infection in patients hospitalized for COVID-19 based on clinical, radiological and microbiological criteria: a retrospective cohort study.
المؤلفون: Coenen S; Division of Infectious Diseases, Department of Internal Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Univ of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., de la Court JR; Division of Infectious Diseases, Department of Internal Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands.; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Univ of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Buis DTP; Division of Infectious Diseases, Department of Internal Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands., Meijboom LJ; Department of Radiology and Nuclear Medicine, Amsterdam Cardiovascular Sciences, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands., Schade RP; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Univ of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Visser CE; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Univ of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., van Hest R; Department of Clinical Pharmacy and Pharmacology, Amsterdam UMC, Univ of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Kuijvenhoven M; Department of Clinical Pharmacy and Pharmacology, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands., Prins JM; Division of Infectious Diseases, Department of Internal Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands., Nijman SFM; Department of Pulmonary Medicine, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands., Sieswerda E; Department of Medical Microbiology and Infection Prevention, Amsterdam UMC, Univ of Amsterdam, Meibergdreef 9, Amsterdam, The Netherlands., Sigaloff KCE; Division of Infectious Diseases, Department of Internal Medicine, Amsterdam Institute for Infection and Immunity, Amsterdam UMC, Vrije Universiteit Amsterdam, De Boelelaan 1117, Amsterdam, The Netherlands. k.sigaloff@amsterdamumc.nl.
المصدر: Antimicrobial resistance and infection control [Antimicrob Resist Infect Control] 2021 Oct 30; Vol. 10 (1), pp. 155. Date of Electronic Publication: 2021 Oct 30.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: BioMed Central Country of Publication: England NLM ID: 101585411 Publication Model: Electronic Cited Medium: Internet ISSN: 2047-2994 (Electronic) Linking ISSN: 20472994 NLM ISO Abbreviation: Antimicrob Resist Infect Control Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : BioMed Central
مواضيع طبية MeSH: Bacterial Infections/*epidemiology , COVID-19/*diagnosis , Coinfection/*epidemiology , Community-Acquired Infections/*epidemiology , Hospitalization/*statistics & numerical data , Pneumonia/*epidemiology, Adult ; Anti-Bacterial Agents/therapeutic use ; Antimicrobial Stewardship ; Bacterial Infections/drug therapy ; Bacterial Infections/microbiology ; COVID-19/complications ; Cohort Studies ; Coinfection/drug therapy ; Community-Acquired Infections/microbiology ; Female ; Humans ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2
مستخلص: Background: We defined the frequency of respiratory community-acquired bacterial co-infection in patients with COVID-19, i.e. patients with a positive SARS-CoV-2 PCR or a COVID-19 Reporting and Data System (CO-RADS) score ≥ 4, based on a complete clinical assessment, including prior antibiotic use, clinical characteristics, inflammatory markers, chest computed tomography (CT) results and microbiological test results.
Methods: Our retrospective study was conducted within a cohort of prospectively included patients admitted for COVID-19 in our tertiary medical centres between 1-3-2020 and 1-6-2020. A multidisciplinary study team developed a diagnostic protocol to retrospectively categorize patients as unlikely, possible or probable bacterial co-infection based on clinical, radiological and microbiological parameters in the first 72 h of admission. Within the three categories, we summarized patient characteristics and antibiotic consumption.
Results: Among 281 included COVID-19 patients, bacterial co-infection was classified as unlikely in 233 patients (82.9%), possible in 35 patients (12.4%) and probable in 3 patients (1.1%). Ten patients (3.6%) could not be classified due to inconclusive data. Within 72 h of hospital admission, 81% of the total study population and 78% of patients classified as unlikely bacterial co-infection received antibiotics.
Conclusions: COVID-19 patients are unlikely to have a respiratory community-acquired bacterial co-infection. This study underpins recommendations for restrictive use of antibacterial drugs in patients with COVID-19.
(© 2021. The Author(s).)
References: Bull World Health Organ. 2020 Jul 1;98(7):442-442A. (PMID: 32742026)
Curr Opin Pulm Med. 2019 May;25(3):242-248. (PMID: 30730311)
Diagn Interv Imaging. 2020 May;101(5):263-268. (PMID: 32291197)
Lancet Infect Dis. 2020 Apr;20(4):425-434. (PMID: 32105637)
Am J Respir Crit Care Med. 2019 Oct 1;200(7):e45-e67. (PMID: 31573350)
Radiology. 2020 Aug;296(2):E97-E104. (PMID: 32339082)
Neth J Med. 2018 Jan;76(1):4-13. (PMID: 29380739)
Clin Microbiol Infect. 2021 Jan;27(1):83-88. (PMID: 32745596)
BMC Med Imaging. 2009 Apr 29;9:7. (PMID: 19400968)
Influenza Other Respir Viruses. 2016 Sep;10(5):394-403. (PMID: 27232677)
N Engl J Med. 2015 Apr 2;372(14):1312-23. (PMID: 25830421)
Clin Infect Dis. 2021 May 18;72(10):e533-e541. (PMID: 32820807)
N Engl J Med. 2021 Apr 22;384(16):1491-1502. (PMID: 33631065)
Ned Tijdschr Geneeskd. 2020 Jul 2;164:. (PMID: 32613784)
BMJ. 2017 Apr 12;357:j1415. (PMID: 28404617)
Emerg Med J. 2004 Jul;21(4):446-8. (PMID: 15208227)
J Am Coll Radiol. 2020 Jun;17(6):701-709. (PMID: 32283052)
J Clin Virol. 2016 Jul;80:12-9. (PMID: 27130980)
Lancet. 2021 May 01;397(10285):1637-1645. (PMID: 33933206)
BMJ. 2020 May 18;369:m1983. (PMID: 32423901)
Euro Surveill. 2020 Nov;25(45):. (PMID: 33183403)
Clin Microbiol Infect. 2020 Dec;26(12):1622-1629. (PMID: 32711058)
Infect Dis (Lond). 2021 Feb;53(2):102-110. (PMID: 33103530)
Clin Infect Dis. 2020 Dec 3;71(9):2459-2468. (PMID: 32358954)
Clin Microbiol Infect. 2020 Oct;26(10):1395-1399. (PMID: 32603803)
Clin Microbiol Infect. 2021 Apr;27(4):653-655. (PMID: 33137513)
AJR Am J Roentgenol. 2000 Jan;174(1):37-41. (PMID: 10628450)
Open Forum Infect Dis. 2020 Dec 21;8(1):ofaa578. (PMID: 33447639)
فهرسة مساهمة: Keywords: Antimicrobial stewardship; Antimicrobial use; COVID-19; Co-infection; Community-acquired pneumonia; SARS-CoV-2
المشرفين على المادة: 0 (Anti-Bacterial Agents)
تواريخ الأحداث: Date Created: 20211031 Date Completed: 20211105 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8556861
DOI: 10.1186/s13756-021-01024-4
PMID: 34717761
قاعدة البيانات: MEDLINE
الوصف
تدمد:2047-2994
DOI:10.1186/s13756-021-01024-4