دورية أكاديمية
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Antimicrobial and Antioxidant Secondary Metabolites from Trifolium baccarinii Chiov. (Fabaceae) and Their Mechanisms of Antibacterial Action.

التفاصيل البيبلوغرافية
العنوان: Antimicrobial and Antioxidant Secondary Metabolites from Trifolium baccarinii Chiov. (Fabaceae) and Their Mechanisms of Antibacterial Action.
المؤلفون: Tsamo DLF; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon., Tamokou JD; Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon., Kengne IC; Research Unit of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon., Ngnokam CDJ; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon., Djamalladine MD; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon., Voutquenne-Nazabadioko L; Groupe Isolement et Structure, Institut de Chimie Moléculaire de Reims (ICMR), CNRS UMR 7312, Bat. 18 B.P. 1039, 51687 Reims Cedex 2, France., Ngnokam D; Research Unit of Applied and Environmental Chemistry, Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67 Dschang, Cameroon.
المصدر: BioMed research international [Biomed Res Int] 2021 Oct 22; Vol. 2021, pp. 3099428. Date of Electronic Publication: 2021 Oct 22 (Print Publication: 2021).
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Hindawi Pub. Co Country of Publication: United States NLM ID: 101600173 Publication Model: eCollection Cited Medium: Internet ISSN: 2314-6141 (Electronic) NLM ISO Abbreviation: Biomed Res Int Subsets: MEDLINE
أسماء مطبوعة: Original Publication: New York, NY : Hindawi Pub. Co.
مواضيع طبية MeSH: Trifolium/*chemistry , Trifolium/*metabolism, Anti-Bacterial Agents/chemistry ; Anti-Infective Agents/chemistry ; Anti-Infective Agents/isolation & purification ; Anti-Infective Agents/pharmacology ; Antifungal Agents/chemistry ; Antifungal Agents/isolation & purification ; Antifungal Agents/pharmacology ; Antioxidants/chemistry ; Antioxidants/isolation & purification ; Antioxidants/pharmacology ; Bacterial Infections ; Fabaceae/chemistry ; Fabaceae/metabolism ; Flavonoids/chemistry ; Microbial Sensitivity Tests ; Plant Extracts/chemistry ; Plant Extracts/pharmacology ; Plants, Medicinal ; Solvents/chemistry
مستخلص: The treatment of infectious diseases with antimicrobial agents continues to present problems in modern-day medicine with many studies showing significant increase in the incidence of bacterial resistance to several antibiotics. The screening of antimicrobial activity of plant extracts and natural products has shown that medicinal plants are made up of a potential source of new anti-infective agents. The aim of this study was to evaluate the antimicrobial and antioxidant activities of extracts and compounds from the whole plant Trifolium baccarinii Chiov. and to determine their modes of antibacterial action. The plant extracts were prepared by maceration in organic solvents. The antimicrobial activities were evaluated using the broth microdilution method. The antioxidant activity was evaluated using the 2,2'-diphenyl-1-picrylhydrazyl radical (DPPH) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS) assays. The mechanisms of antibacterial action were determined by lysis, salt tolerance assays, and antioxidant enzyme activities. The cytotoxic effect on the erythrocytes was determined by a spectrophotometric method. Biochanin A, formononetin, luteolin, luteolin-4'-O- β -D-glucopyranoside, 4,7,2'-trihydroxy-4'-methoxyisoflavanol, sissotrin, 1-methyl- β -D-glucopyranoside, ononin, D-mannitol, and 3-O- β -D-glucuronopyranosylsoyasapogenol B were isolated from Trifolium baccarinii . The MeOH, EtOAc, and n -BuOH extracts as well as biochanin A, formononetin, luteolin, luteolin-4'-O- β -D-glucopyranoside, 4,7,2'-trihydroxy-4'-methoxyisoflavanol, and sissotrin from Trifolium baccarinii displayed the highest antimicrobial and antioxidant activities. The MeOH extract and 4,7,2'-trihydroxy-4'-methoxyisoflavanol exhibited antibacterial activity through the bacteriolytic effect and reduction of the antioxidant defenses in the bacterial cells. The present study portrays Trifolium baccarinii as a potential natural source of antibacterial, antifungal, and antioxidant agents.
Competing Interests: The authors declare that they have no conflicts of interest.
(Copyright © 2021 Donald Léonel Feugap Tsamo et al.)
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المشرفين على المادة: 0 (Anti-Bacterial Agents)
0 (Anti-Infective Agents)
0 (Antifungal Agents)
0 (Antioxidants)
0 (Flavonoids)
0 (Plant Extracts)
0 (Solvents)
تواريخ الأحداث: Date Created: 20211101 Date Completed: 20220124 Latest Revision: 20220124
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8556085
DOI: 10.1155/2021/3099428
PMID: 34722760
قاعدة البيانات: MEDLINE
الوصف
تدمد:2314-6141
DOI:10.1155/2021/3099428