دورية أكاديمية
Comparison of the Cardiovascular Effects of Two Medetomidine Doses Combined with Tiletamine-Zolazepam for the Immobilization of Red Deer Hinds (Cervus elaphus).
| العنوان: | Comparison of the Cardiovascular Effects of Two Medetomidine Doses Combined with Tiletamine-Zolazepam for the Immobilization of Red Deer Hinds (Cervus elaphus). |
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| المؤلفون: | Rauch H; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria., Pohlin F; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria., Einwaller J; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria., Habe M; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria., Painer J; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria.; These authors contributed equally to this work., Stalder G; Research Institute of Wildlife Ecology, University of Veterinary Medicine, Vienna, Savoyenstrasse 1, 1160 Vienna, Austria.; These authors contributed equally to this work. |
| المصدر: | Journal of wildlife diseases [J Wildl Dis] 2022 Jan 01; Vol. 58 (1), pp. 188-193. |
| نوع المنشور: | Clinical Trial, Veterinary; Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Wildlife Disease Association Country of Publication: United States NLM ID: 0244160 Publication Model: Print Cited Medium: Internet ISSN: 1943-3700 (Electronic) Linking ISSN: 00903558 NLM ISO Abbreviation: J Wildl Dis Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: Lawrence, KS : Wildlife Disease Association Original Publication: Ames, Iowa, Wildlife Disease Assn. |
| مواضيع طبية MeSH: | Deer*/physiology , Zolazepam*/pharmacology, Anesthetics, Combined/pharmacology ; Anesthetics, Dissociative/pharmacology ; Animals ; Female ; Heart Rate ; Hypnotics and Sedatives/pharmacology ; Immobilization/methods ; Immobilization/veterinary ; Medetomidine/pharmacology ; Tiletamine/pharmacology |
| مستخلص: | Wild animal immobilization often requires high doses of α2-adrenoceptor agonists. Despite their desired sedative and analgetic effects, well-recognized cardiovascular side effects, such as hypertension and bradycardia, remain a major concern. We compared the effect of two medetomidine doses on intra-arterial blood pressure and heart rate in 13 captive, female red deer (Cervus elaphus) immobilized during winter. Each animal was randomly assigned to receive either 80 µg/kg (group L) or 100 µg/kg (group H) medetomidine, combined with 3 mg/kg tiletamine-zolazepam administered intramuscularly. Changes in cardiovascular variables over time and differences between the groups were analyzed using linear mixed-effect models. Induction time was faster in group L compared with group H; recovery time did not differ between groups. Initially, the arterial blood pressure was higher in group H compared with group L, but differences between groups diminished during anesthesia. Moreover, the decline in arterial blood pressure in group H was more rapid. Heart rate was significantly lower in group L, but bradycardia was not observed. The higher medetomidine dose did not reduce induction time, and initial hypertension was reduced by administering the lower dose. Therefore, although the sample size was small and, thus, the significance of results might be limited, we suggest using 80 µg/kg instead of 100 µg/kg medetomidine when combined with 3 mg/kg tiletamine-zolazepam for the immobilization of female red deer. (© Wildlife Disease Association 2022.) |
| فهرسة مساهمة: | Keywords: Bradycardia; dose-dependent effect; hypertension; medetomidine; red deer |
| المشرفين على المادة: | 0 (Anesthetics, Combined) 0 (Anesthetics, Dissociative) 0 (Hypnotics and Sedatives) 2YFC543249 (Tiletamine) G1R474U58U (Zolazepam) MR15E85MQM (Medetomidine) |
| تواريخ الأحداث: | Date Created: 20211101 Date Completed: 20220330 Latest Revision: 20220531 |
| رمز التحديث: | 20240829 |
| DOI: | 10.7589/JWD-D-20-00229 |
| PMID: | 34724568 |
| قاعدة البيانات: | MEDLINE |
| تدمد: | 1943-3700 |
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| DOI: | 10.7589/JWD-D-20-00229 |