دورية أكاديمية
Obstructive sleep apnea in children and adolescents with cystic fibrosis and preserved lung function or mild impairment: a systematic review and meta-analysis of prevalence.
| العنوان: | Obstructive sleep apnea in children and adolescents with cystic fibrosis and preserved lung function or mild impairment: a systematic review and meta-analysis of prevalence. |
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| المؤلفون: | de Sousa LP; Department of Physiotherapy, Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, Espírito Santo, Brazil., Liberato FMG; Cystic Fibrosis Reference Center, Hospital Infantil Nossa Senhora da Glória, Vitória, Espírito Santo, Brazil., Vendrusculo FM; Laboratory of Pediatric Physical Activity, Centro Infant, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil., Donadio MVF; Laboratory of Pediatric Physical Activity, Centro Infant, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, Rio Grande do Sul, Brazil., Barbosa RRB; Department of Physiotherapy, Escola Superior de Ciências da Santa Casa de Misericórdia de Vitória, Vitória, Espírito Santo, Brazil. Electronic address: robertaribeirob@hotmail.com. |
| المصدر: | Sleep medicine [Sleep Med] 2021 Dec; Vol. 88, pp. 36-43. Date of Electronic Publication: 2021 Oct 01. |
| نوع المنشور: | Journal Article; Meta-Analysis; Research Support, Non-U.S. Gov't; Review; Systematic Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Science Country of Publication: Netherlands NLM ID: 100898759 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1878-5506 (Electronic) Linking ISSN: 13899457 NLM ISO Abbreviation: Sleep Med Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Amsterdam ; New York : Elsevier Science, c2000- |
| مواضيع طبية MeSH: | Cystic Fibrosis*/complications , Cystic Fibrosis*/epidemiology , Sleep Apnea, Obstructive*/epidemiology, Adolescent ; Child ; Humans ; Lung ; Prevalence ; Quality of Life |
| مستخلص: | Objective/background: Sleep disorders in cystic fibrosis may be present before daytime clinical manifestations, regardless of lung function impairment, affecting quality of life and disease progression. This study investigated the prevalence of obstructive sleep apnea in children and adolescents with cystic fibrosis and preserved lung function or mild impairment, and evaluated its association with clinical variables. Methods: A systematic review with meta-analysis of prevalence was conducted, including observational studies with polysomnographies in patients with cystic fibrosis who presented mean lung function values > 60% predicted. The methodological quality of the studies was analyzed, and a meta-analysis was performed to assess the prevalence of obstructive sleep apnea. Results: Of the 2318 studies identified, 7 were included in the systematic review and 6 in the meta-analysis of prevalence. The confounding factors and strategies identified were the items with greatest weakness in the methodological quality assessment. Most studies were cross-sectional, and sample size ranged from 9 to 67 individuals. The most frequent criterion for defining obstructive sleep apnea was apnea-hypopnea index (AHI) > 1 per hour. The prevalence found ranged from 32.3 to 100% and the pooled prevalence was 65% (I 2 = 53.4%), considering AHI>1, and 52% (I 2 = 89.4%) for AHI>2 per hour. It was not possible to verify the association between obstructive sleep apnea and clinical variables. Conclusions: A high prevalence of obstructive sleep apnea in children and adolescents with cystic fibrosis was found, regardless of age and lung function impairment, reinforcing the importance of investigating sleep-disordered breathing during clinical visits even when lung function is not yet compromised. (Copyright © 2021 Elsevier B.V. All rights reserved.) |
| فهرسة مساهمة: | Keywords: Cystic fibrosis; Obstructive sleep apnea; Sleep-disordered breathing |
| تواريخ الأحداث: | Date Created: 20211103 Date Completed: 20220106 Latest Revision: 20220106 |
| رمز التحديث: | 20240628 |
| DOI: | 10.1016/j.sleep.2021.09.017 |
| PMID: | 34731826 |
| قاعدة البيانات: | MEDLINE |
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Full Text Finder | تدمد: | 1878-5506 |
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| DOI: | 10.1016/j.sleep.2021.09.017 |