دورية أكاديمية
أعرض في EDS

Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin's lymphoma.

التفاصيل البيبلوغرافية
العنوان: Expression of L-type amino acid transporter 1 is a poor prognostic factor for Non-Hodgkin's lymphoma.
المؤلفون: Jigjidkhorloo N; Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan.; Center of Hematology and Blood & Marrow Transplantation, The First Central Hospital of Mongolia, Ulaanbaatar, 14210, Mongolia., Kanekura K; Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan. kanekura@tokyo-med.ac.jp., Matsubayashi J; Department of Anatomical Pathology, Tokyo Medical University Hospital, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan., Akahane D; Department of Hematology, Tokyo Medical University Hospital, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan., Fujita K; Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan., Oikawa K; Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan., Kurata A; Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan., Takanashi M; Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan., Endou H; J-Pharma Co., Ltd., 75-1 Ono-cho, Tsurumi-ku, Yokohama, Kanagawa, 230-0046, Japan., Nagao T; Department of Anatomical Pathology, Tokyo Medical University Hospital, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan., Gotoh A; Department of Hematology, Tokyo Medical University Hospital, 6-7-1 Nishi-Shinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan., Norov O; Center of Hematology and Blood & Marrow Transplantation, The First Central Hospital of Mongolia, Ulaanbaatar, 14210, Mongolia., Kuroda M; Department of Molecular Pathology, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo, 160-8402, Japan. kuroda@tokyo-med.ac.jp.
المصدر: Scientific reports [Sci Rep] 2021 Nov 04; Vol. 11 (1), pp. 21638. Date of Electronic Publication: 2021 Nov 04.
نوع المنشور: Journal Article; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Publishing Group Country of Publication: England NLM ID: 101563288 Publication Model: Electronic Cited Medium: Internet ISSN: 2045-2322 (Electronic) Linking ISSN: 20452322 NLM ISO Abbreviation: Sci Rep Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Publishing Group, copyright 2011-
مواضيع طبية MeSH: Large Neutral Amino Acid-Transporter 1/*genetics , Lymphoma, Non-Hodgkin/*metabolism, Adult ; Aged ; Aged, 80 and over ; Amino Acid Transport System L/metabolism ; Amino Acid Transport Systems/metabolism ; Cell Line, Tumor ; Cell Proliferation/genetics ; Female ; Gene Expression/genetics ; Gene Expression Profiling/methods ; Gene Expression Regulation, Neoplastic/genetics ; Humans ; Large Neutral Amino Acid-Transporter 1/metabolism ; Lymphoma, Non-Hodgkin/physiopathology ; Male ; Middle Aged ; Prognosis ; Transcriptome/genetics
مستخلص: L-type neutral amino acid transporter 1 (LAT1) is a heterodimeric membrane transport protein involved in neutral amino acid transport. LAT1 is highly expressed in various malignant solid tumors and plays an essential role in cell proliferation. However, its role in malignant lymphoma remains unknown. Here, we evaluated LAT1 expression level in tissues from 138 patients with Non-Hodgkin lymphoma (NHL). Overexpression of LAT1 was confirmed in all types of NHL and we found that there is a significant correlation between the level of LAT1 expression and lymphoma grade. The LAT1 expression was higher in aggressive types of lymphomas when compared with static types of lymphomas, suggesting that active tumor proliferation requires nutrient uptake via LAT1. The expression level of LAT1 was inversely correlated with patients' survival span. Furthermore, pharmacological inhibition of LAT1 by a specific inhibitor JPH203 inhibits lymphoma cell growth. In conclusion, our study demonstrated that LAT1 expression can be used as a prognostic marker for patients with NHL and targeting LAT1 by JPH203 can be a novel therapeutic modality for NHL.
(© 2021. The Author(s).)
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المشرفين على المادة: 0 (Amino Acid Transport System L)
0 (Amino Acid Transport Systems)
0 (Large Neutral Amino Acid-Transporter 1)
0 (SLC7A5 protein, human)
تواريخ الأحداث: Date Created: 20211105 Date Completed: 20220125 Latest Revision: 20220125
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8569019
DOI: 10.1038/s41598-021-00811-8
PMID: 34737339
قاعدة البيانات: MEDLINE
الوصف
تدمد:2045-2322
DOI:10.1038/s41598-021-00811-8