دورية أكاديمية
أعرض في EDS

Explorations into Peptide Nucleic Acid Contrast Agents as Emerging Scaffolds for Breakthrough Solutions in Medical Imaging and Diagnosis.

التفاصيل البيبلوغرافية
العنوان: Explorations into Peptide Nucleic Acid Contrast Agents as Emerging Scaffolds for Breakthrough Solutions in Medical Imaging and Diagnosis.
المؤلفون: Exner RM; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom., Paisey SJ; Wales Research & Diagnostic Positron Emission Tomography Imaging Centre (PETIC), School of Medicine, Cardiff University, University Hospital of Wales, Heath Park, Cardiff CF14 4XN, United Kingdom., Redman JE; School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff CF10 3AT, United Kingdom., Pascu SI; Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.; Centre for Sustainable and Circular Technologies, 1 South, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.; Centre for Therapeutic Innovation, 3 West 2.03, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom.
المصدر: ACS omega [ACS Omega] 2021 Oct 19; Vol. 6 (43), pp. 28455-28462. Date of Electronic Publication: 2021 Oct 19 (Print Publication: 2021).
نوع المنشور: Journal Article; Review
اللغة: English
بيانات الدورية: Publisher: American Chemical Society Country of Publication: United States NLM ID: 101691658 Publication Model: eCollection Cited Medium: Internet ISSN: 2470-1343 (Electronic) Linking ISSN: 24701343 NLM ISO Abbreviation: ACS Omega Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Washington, D.C. : American Chemical Society, [2016]-
مستخلص: Peptide nucleic acids (PNAs, nucleic acid analogues with a peptide backbone rather than a phosphoribosyl backbone) have emerged as promising chemical agents in antigene or antisense therapeutics, as splicing modulators or in gene editing. Their main benefits, compared to DNA or RNA agents, are their biochemical stability and the lack of negative charges throughout the backbone, leading to negligible electrostatic interaction with the strand with which they are hybridizing. As a result, hybridization of PNA strands with DNA or RNA strands leads to higher binding energies and melting temperatures. A lack of natural transporters, however, necessitates the formation of PNA-containing chimeras or the formulation of nanoparticular cell delivery methods. Here, we set out to explore the progress made in using imaging agents based on PNAs in diagnostic applications and highlight selected developments and challenges.
Competing Interests: The authors declare no competing financial interest.
(© 2021 The Authors. Published by American Chemical Society.)
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تواريخ الأحداث: Date Created: 20211108 Latest Revision: 20240404
رمز التحديث: 20240404
مُعرف محوري في PubMed: PMC8569549
DOI: 10.1021/acsomega.1c03994
PMID: 34746541
قاعدة البيانات: MEDLINE
الوصف
تدمد:2470-1343
DOI:10.1021/acsomega.1c03994