دورية أكاديمية
أعرض في EDS

Spatial regulation of cell motility and its fitness effect in a surface-attached bacterial community.

التفاصيل البيبلوغرافية
العنوان: Spatial regulation of cell motility and its fitness effect in a surface-attached bacterial community.
المؤلفون: Şimşek E; Department of Physics, Emory University, Atlanta, GA, 30322, USA.; Department of Biomedical Engineering, Duke University, Durham, NC, 27708, USA., Dawson E; Department of Physics, Emory University, Atlanta, GA, 30322, USA., Rather PN; Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, 30322, USA.; Department of Microbiology and Immunology, Emory University, Atlanta, GA, 30322, USA.; Research Service, Atlanta VA Medical Center, Decatur, GA, 30033, USA., Kim M; Department of Physics, Emory University, Atlanta, GA, 30322, USA. minsu.kim@emory.edu.; Graduate Division of Biological and Biomedical Sciences, Emory University, Atlanta, GA, 30322, USA. minsu.kim@emory.edu.
المصدر: The ISME journal [ISME J] 2022 Apr; Vol. 16 (4), pp. 1004-1011. Date of Electronic Publication: 2021 Nov 10.
نوع المنشور: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, Non-U.S. Gov't
اللغة: English
بيانات الدورية: Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101301086 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1751-7370 (Electronic) Linking ISSN: 17517362 NLM ISO Abbreviation: ISME J Subsets: MEDLINE
أسماء مطبوعة: Original Publication: London : Nature Pub. Group
مواضيع طبية MeSH: Gene Expression Regulation, Bacterial* , Proteus mirabilis*/genetics , Proteus mirabilis*/metabolism, Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; Cell Movement
مستخلص: On a surface, microorganisms grow into a multi-cellular community. When a community becomes densely populated, cells migrate away to expand the community's territory. How microorganisms regulate surface motility to optimize expansion remains poorly understood. Here, we characterized surface motility of Proteus mirabilis. P. mirabilis is well known for its ability to expand its colony rapidly on a surface. Cursory visual inspection of an expanding colony suggests partial migration, i.e., one fraction of a population migrates while the other is sessile. Quantitative microscopic imaging shows that this migration pattern is determined by spatially inhomogeneous regulation of cell motility. Further analyses reveal that this spatial regulation is mediated by the Rcs system, which represses the expression of the motility regulator (FlhDC) in a nutrient-dependent manner. Alleviating this repression increases the colony expansion speed but results in a rapid drop in the number of viable cells, lowering population fitness. These findings collectively demonstrate how Rcs regulates cell motility dynamically to increase the fitness of an expanding bacterial population, illustrating a fundamental trade-off underlying bacterial colonization of a surface.
(© 2021. The Author(s), under exclusive licence to International Society for Microbial Ecology.)
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معلومات مُعتمدة: I01 BX001725 United States BX BLRD VA; IK6 BX004470 United States BX BLRD VA
المشرفين على المادة: 0 (Bacterial Proteins)
تواريخ الأحداث: Date Created: 20211111 Date Completed: 20220412 Latest Revision: 20230402
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8940935
DOI: 10.1038/s41396-021-01148-w
PMID: 34759303
قاعدة البيانات: MEDLINE
الوصف
تدمد:1751-7370
DOI:10.1038/s41396-021-01148-w