دورية أكاديمية
أعرض في EDS

Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts ( Cyclopia sp.)-A Comparison Ex Vivo Study.

التفاصيل البيبلوغرافية
العنوان: Mangiferin and Hesperidin Transdermal Distribution and Permeability through the Skin from Solutions and Honeybush Extracts ( Cyclopia sp.)-A Comparison Ex Vivo Study.
المؤلفون: Hering A; Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, 80-416 Gdansk, Poland., Ochocka JR; Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, 80-416 Gdansk, Poland., Baranska H; Department of Pharmaceutical Technology, Medical University of Gdansk, 80-416 Gdansk, Poland., Cal K; Department of Pharmaceutical Technology, Medical University of Gdansk, 80-416 Gdansk, Poland., Stefanowicz-Hajduk J; Department of Biology and Pharmaceutical Botany, Medical University of Gdansk, 80-416 Gdansk, Poland.
المصدر: Molecules (Basel, Switzerland) [Molecules] 2021 Oct 29; Vol. 26 (21). Date of Electronic Publication: 2021 Oct 29.
نوع المنشور: Comparative Study; Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI Country of Publication: Switzerland NLM ID: 100964009 Publication Model: Electronic Cited Medium: Internet ISSN: 1420-3049 (Electronic) Linking ISSN: 14203049 NLM ISO Abbreviation: Molecules Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI, c1995-
مواضيع طبية MeSH: Cyclopia Plant/*chemistry , Hesperidin/*pharmacology , Plant Extracts/*pharmacology , Skin/*drug effects , Xanthones/*pharmacology, Administration, Cutaneous ; Adult ; Hesperidin/administration & dosage ; Hesperidin/isolation & purification ; Humans ; Microscopy, Fluorescence ; Middle Aged ; Plant Extracts/administration & dosage ; Plant Extracts/isolation & purification ; Solutions ; Xanthones/administration & dosage ; Xanthones/isolation & purification
مستخلص: Polyphenolic compounds-mangiferin and hesperidin-are, among others, the most important secondary metabolites of African shrub Cyclopia sp. (honeybush). The aim of this study was to compare the percutaneous absorption of mangiferin and hesperidin from solutions (water, ethanol 50%, ( v/v )) and extracts obtained from green and fermented honeybush (water, ethanol 50%, ( v/v )). Research was performed with the Bronaugh cells, on human dorsal skin. The mangiferin and hesperidin distributions in skin layers (stratum corneum, epidermis, and dermis) and in acceptor fluid (in every 2, 4, 6, and 24 h) were evaluated by HPLC-Photodiode Array Coulometric and Coulometric Electrochemical Array Detection. The transdermal distribution of hesperidin was also demonstrated by fluorescence microscopy. Results indicated that mangiferin and hesperidin were able to cross the stratum corneum and penetrate into the epidermis and dermis. An advantage of hesperidin penetration into the skin from the water over ethanol solution was observed (451.02 ± 14.50 vs. 357.39 ± 4.51 ng/cm 2 ), as well as in the mangiferin study (127.56 ± 9.49 vs. 97.23 ± 2.92 ng/cm 2 ). Furthermore, mangiferin penetration was more evident from nonfermented honeybush ethanol extract (189.85 ± 4.11 ng/cm 2 ) than from solutions. The permeation of mangiferin and hesperidin through the skin to the acceptor fluid was observed regardless of whether the solution or the honeybush extract was applied. The highest ability to permeate the skin was demonstrated for the water solution of hesperidin (250.92 ± 16.01 ng/cm 2 ), while the hesperidin occurring in the extracts permeated in a very low capacity. Mangiferin from nonfermented honeybush ethanol extract had the highest ability to permeate to the acceptor fluid within 24 h (152.36 ± 8.57 ng/cm 2 ).
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فهرسة مساهمة: Keywords: Fabaceae; HPLC; fluorescent microscopy; honeybush; skin penetration; skin permeation
المشرفين على المادة: 0 (Plant Extracts)
0 (Solutions)
0 (Xanthones)
1M84LD0UMD (mangiferin)
E750O06Y6O (Hesperidin)
تواريخ الأحداث: Date Created: 20211113 Date Completed: 20211203 Latest Revision: 20211214
رمز التحديث: 20240829
مُعرف محوري في PubMed: PMC8587049
DOI: 10.3390/molecules26216547
PMID: 34770957
قاعدة البيانات: MEDLINE
الوصف
تدمد:1420-3049
DOI:10.3390/molecules26216547