دورية أكاديمية
HDL proteome remodeling associates with COVID-19 severity.
| العنوان: | HDL proteome remodeling associates with COVID-19 severity. |
|---|---|
| المؤلفون: | Souza Junior DR; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Silva ARM; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Rosa-Fernandes L; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil., Reis LR; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Alexandria G; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Bhosale SD; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Ghilardi FR; Institute for Tropical Medicine, University of São Paulo, São Paulo, Brazil., Dalçóquio TF; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Bertolin AJ; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Nicolau JC; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil., Marinho CRF; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil., Wrenger C; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil., Larsen MR; Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark., Siciliano RF; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil; Division of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil., Di Mascio P; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil., Palmisano G; Department of Parasitology, Institute of Biomedical Science, University of São Paulo, São Paulo, Brazil. Electronic address: palmisano.gp@usp.br., Ronsein GE; Department of Biochemistry, Chemistry Institute, University of São Paulo, São Paulo, Brazil. Electronic address: ronsein@iq.usp.br. |
| المصدر: | Journal of clinical lipidology [J Clin Lipidol] 2021 Nov-Dec; Vol. 15 (6), pp. 796-804. Date of Electronic Publication: 2021 Oct 31. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Elsevier Country of Publication: United States NLM ID: 101300157 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1933-2874 (Print) Linking ISSN: 18764789 NLM ISO Abbreviation: J Clin Lipidol Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: New York, NY : Elsevier |
| مواضيع طبية MeSH: | COVID-19/*blood , COVID-19/*pathology , Lipoproteins, HDL/*blood, Adult ; Apolipoproteins/blood ; Cholesterol, HDL/blood ; Female ; Humans ; Male ; Mass Spectrometry ; Middle Aged ; Proteomics ; Serum Amyloid A Protein/metabolism ; Triglycerides/blood |
| مستخلص: | Background: Besides the well-accepted role in lipid metabolism, high-density lipoprotein (HDL) also seems to participate in host immune response against infectious diseases. Objective: We used a quantitative proteomic approach to test the hypothesis that alterations in HDL proteome associate with severity of Coronavirus disease 2019 (COVID-19). Methods: Based on clinical criteria, subjects (n=41) diagnosed with COVID-19 were divided into two groups: a group of subjects presenting mild symptoms and a second group displaying severe symptoms and requiring hospitalization. Using a proteomic approach, we quantified the levels of 29 proteins in HDL particles derived from these subjects. Results: We showed that the levels of serum amyloid A 1 and 2 (SAA1 and SAA2, respectively), pulmonary surfactant-associated protein B (SFTPB), apolipoprotein F (APOF), and inter-alpha-trypsin inhibitor heavy chain H4 (ITIH4) were increased by more than 50% in hospitalized patients, independently of sex, HDL-C or triglycerides when comparing with subjects presenting only mild symptoms. Altered HDL proteins were able to classify COVID-19 subjects according to the severity of the disease (error rate 4.9%). Moreover, apolipoprotein M (APOM) in HDL was inversely associated with odds of death due to COVID-19 complications (odds ratio [OR] per 1-SD increase in APOM was 0.27, with 95% confidence interval [CI] of 0.07 to 0.72, P=0.007). Conclusion: Our results point to a profound inflammatory remodeling of HDL proteome tracking with severity of COVID-19 infection. They also raise the possibility that HDL particles could play an important role in infectious diseases. (Copyright © 2021. Published by Elsevier Inc.) |
| فهرسة مساهمة: | Keywords: COVID-19; HDL; Infection; Quantitative proteomics |
| المشرفين على المادة: | 0 (Apolipoproteins) 0 (Cholesterol, HDL) 0 (Lipoproteins, HDL) 0 (Serum Amyloid A Protein) 0 (Triglycerides) 0 (apolipoprotein F) |
| تواريخ الأحداث: | Date Created: 20211122 Date Completed: 20220103 Latest Revision: 20220103 |
| رمز التحديث: | 20221213 |
| مُعرف محوري في PubMed: | PMC8557113 |
| DOI: | 10.1016/j.jacl.2021.10.005 |
| PMID: | 34802985 |
| قاعدة البيانات: | MEDLINE |
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