دورية أكاديمية
The Role of Glucocorticoids in Inflammatory Diseases.
| العنوان: | The Role of Glucocorticoids in Inflammatory Diseases. |
|---|---|
| المؤلفون: | Reichardt SD; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany., Amouret A; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany., Muzzi C; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany., Vettorazzi S; Institute of Comparative Molecular Endocrinology, Ulm University, 89081 Ulm, Germany., Tuckermann JP; Institute of Comparative Molecular Endocrinology, Ulm University, 89081 Ulm, Germany., Lühder F; Institute for Neuroimmunology and Multiple Sclerosis Research, University Medical Center Göttingen, 37075 Göttingen, Germany., Reichardt HM; Institute for Cellular and Molecular Immunology, University Medical Center Göttingen, 37073 Göttingen, Germany. |
| المصدر: | Cells [Cells] 2021 Oct 28; Vol. 10 (11). Date of Electronic Publication: 2021 Oct 28. |
| نوع المنشور: | Journal Article; Research Support, Non-U.S. Gov't; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: MDPI Country of Publication: Switzerland NLM ID: 101600052 Publication Model: Electronic Cited Medium: Internet ISSN: 2073-4409 (Electronic) Linking ISSN: 20734409 NLM ISO Abbreviation: Cells Subsets: MEDLINE |
| أسماء مطبوعة: | Original Publication: Basel, Switzerland : MDPI |
| مواضيع طبية MeSH: | Glucocorticoids/*metabolism , Inflammation/*metabolism, Animals ; Disease Models, Animal ; Humans ; Inflammation/pathology ; Models, Biological ; Nanoparticles/chemistry ; Phenotype |
| مستخلص: | For more than 70 years, glucocorticoids (GCs) have been a powerful and affordable treatment option for inflammatory diseases. However, their benefits do not come without a cost, since GCs also cause side effects. Therefore, strong efforts are being made to improve their therapeutic index. In this review, we illustrate the mechanisms and target cells of GCs in the pathogenesis and treatment of some of the most frequent inflammatory disorders affecting the central nervous system, the gastrointestinal tract, the lung, and the joints, as well as graft-versus-host disease, which often develops after hematopoietic stem cell transplantation. In addition, an overview is provided of novel approaches aimed at improving GC therapy based on chemical modifications or GC delivery using nanoformulations. GCs remain a topic of highly active scientific research despite being one of the oldest class of drugs in medical use. |
| التعليقات: | Comment in: Cells. 2022 Dec 13;11(24):. (PMID: 36552795) |
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| معلومات مُعتمدة: | RE 4439/1-1 Deutsche Forschungsgemeinschaft; RE 1631/17-1 Deutsche Forschungsgemeinschaft |
| فهرسة مساهمة: | Keywords: acute lung injury; asthma; glucocorticoid receptor; graft-versus-host-disease; inflammatory bowel disease; multiple sclerosis; nanoparticles; rheumatoid arthritis |
| المشرفين على المادة: | 0 (Glucocorticoids) |
| تواريخ الأحداث: | Date Created: 20211127 Date Completed: 20220103 Latest Revision: 20230115 |
| رمز التحديث: | 20230116 |
| مُعرف محوري في PubMed: | PMC8616489 |
| DOI: | 10.3390/cells10112921 |
| PMID: | 34831143 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2073-4409 |
|---|---|
| DOI: | 10.3390/cells10112921 |