دورية أكاديمية
أعرض في EDS

Genotype-Dependent Immunogenicity of Dengue Virus Type 2 Asian I and Asian/American Genotypes in Common Marmoset ( Callithrix jacchus) : Discrepancy in Neutralizing and Infection-Enhancing Antibody Levels between Genotypes.

التفاصيل البيبلوغرافية
العنوان: Genotype-Dependent Immunogenicity of Dengue Virus Type 2 Asian I and Asian/American Genotypes in Common Marmoset ( Callithrix jacchus) : Discrepancy in Neutralizing and Infection-Enhancing Antibody Levels between Genotypes.
المؤلفون: Azami NAM; Department of Virology 1, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.; UKM Medical Molecular Biology Institute, Universiti Kebangsaan Malaysia, Kuala Lumpur 56000, Malaysia., Moi ML; School of International Health, The University of Tokyo, Tokyo 113-0033, Japan., Ami Y; Division of Experimental Animal Research, National Institute of Infectious Diseases, Tokyo 208-0011, Japan., Suzaki Y; Division of Experimental Animal Research, National Institute of Infectious Diseases, Tokyo 208-0011, Japan., Taniguchi S; Department of Virology 1, National Institute of Infectious Diseases, Tokyo 162-8640, Japan., Tajima S; Department of Virology 1, National Institute of Infectious Diseases, Tokyo 162-8640, Japan., Saijo M; Department of Virology 1, National Institute of Infectious Diseases, Tokyo 162-8640, Japan., Takasaki T; Kanagawa Prefectural Institute of Public Health, Kanagawa 253-0087, Japan., Kurane I; National Institute of Infectious Diseases, Tokyo 162-8640, Japan., Lim CK; Department of Virology 1, National Institute of Infectious Diseases, Tokyo 162-8640, Japan.
المصدر: Microorganisms [Microorganisms] 2021 Oct 21; Vol. 9 (11). Date of Electronic Publication: 2021 Oct 21.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: MDPI AG Country of Publication: Switzerland NLM ID: 101625893 Publication Model: Electronic Cited Medium: Print ISSN: 2076-2607 (Print) Linking ISSN: 20762607 NLM ISO Abbreviation: Microorganisms Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Basel, Switzerland : MDPI AG, [2013]-
مستخلص: Owing to genotype-specific neutralizing antibodies, analyzing differences in the immunogenic variation among dengue virus (DENV) genotypes is central to effective vaccine development. Herein, we characterized the viral kinetics and antibody response induced by DENV type 2 Asian I (AI) and Asian/American (AA) genotypes using marmosets ( Callithrix jacchus ) as models. Two groups of marmosets were inoculated with AI and AA genotypes, and serial plasma samples were collected. Viremia levels were determined using quantitative reverse transcription-PCR, plaque assays, and antigen enzyme-linked immunosorbent assay (ELISA). Anti-DENV immunoglobulin M and G antibodies, neutralizing antibody titer, and antibody-dependent enhancement (ADE) activity were determined using ELISA, plaque reduction neutralization test, and ADE assay, respectively. The AI genotype induced viremia for a longer duration, but the AA genotype induced higher levels of viremia. After four months, the neutralizing antibody titer induced by the AA genotype remained high, but that induced by the AI genotype waned. ADE activity toward Cosmopolitan genotypes was detected in marmosets inoculated with the AI genotype. These findings indicate discrepancies between heterologous genotypes that influence neutralizing antibodies and viremia in marmosets, a critical issue in vaccine development.
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معلومات مُعتمدة: Research Program on Emerging and Re-emerging Infectious Diseases of the Japan Agency for Medical Research and Development (AMED) under grant numbers 18fk0108035, 18fk0108067, and JP21fk0108123, Research on Emerging and Re-Emerging Infectious Diseases (21f Japan Agency for Medical Research and Development; a grant-in-aid for Scientific Research (Kiban B no. 25293112) Ministry of Education, Culture, Sports, Science and Technology
فهرسة مساهمة: Keywords: FcγR-expressing BHK cells; common marmoset; dengue; genotypes; infection-enhancing; neutralizing antibody
تواريخ الأحداث: Date Created: 20211127 Latest Revision: 20211130
رمز التحديث: 20231215
مُعرف محوري في PubMed: PMC8618970
DOI: 10.3390/microorganisms9112196
PMID: 34835327
قاعدة البيانات: MEDLINE
الوصف
تدمد:2076-2607
DOI:10.3390/microorganisms9112196