دورية أكاديمية
QimmeqHealth-thyroid status of Greenland sled dogs (Canis lupus familiaris borealis).
| العنوان: | QimmeqHealth-thyroid status of Greenland sled dogs (Canis lupus familiaris borealis). |
|---|---|
| المؤلفون: | Gjaldbæk BW; Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870, Frederiksberg C, Denmark., Andersen-Ranberg EU; Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870, Frederiksberg C, Denmark., Langebæk R; Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870, Frederiksberg C, Denmark., Krogh AKH; Department of Veterinary Clinical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Dyrlægevej 16, 1870, Frederiksberg C, Denmark. akrk@sund.ku.dk. |
| المصدر: | Acta veterinaria Scandinavica [Acta Vet Scand] 2021 Nov 29; Vol. 63 (1), pp. 51. Date of Electronic Publication: 2021 Nov 29. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: BioMed Central Country of Publication: England NLM ID: 0370400 Publication Model: Electronic Cited Medium: Internet ISSN: 1751-0147 (Electronic) Linking ISSN: 0044605X NLM ISO Abbreviation: Acta Vet Scand Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: London : BioMed Central Original Publication: Copenhagen. |
| مواضيع طبية MeSH: | Dogs* , Thyroid Gland*, Animals ; Female ; Greenland ; Male ; Reference Values ; Thyrotropin/blood ; Thyroxine/blood |
| مستخلص: | Background: Greenland sled dogs (GSD) are a unique, genetically isolated population of dogs living under exceptional environmental conditions. Metabolism, and thereby thyroid hormones are affected by multiple factors. Among other activity, energy balance and environmental conditions are important. A breed-specific reference interval (RI) can be useful for diagnostics of potential thyroid-related pathologies. The aim of this study was to establish RIs of the thyroid hormones thyroxin (T4), free thyroxin (fT4), and thyroid stimulating hormone (TSH) in GSD. In addition to evaluate the effect of sex, age, season, management, and body condition score (BCS) in GSD. Physical exams and cephalic venous blood sampling were performed in the period of 2018-2019 from 265 GSD managed either privately or by the Danish navy. Serum biochemical analyses, including C-reactive protein, were performed and RIs were determined for TSH, T4 and fT4 in only healthy dogs. The RIs were determined using American Society for Veterinary Clinical Pathology guidelines and the effect of varying factors were evaluated by linear regression and further tested by Mann-Whitney test. Results: 144 GSD were included in the reference group resulting in RIs: T4: 6.44-48.65 nmol/L; fT4: 3.91-18.51 pmol/L; and TSH: 0.04-0.55 ng/mL. Female GSD had significantly higher concentrations of T4 (P = 0.039) and fT4 (P = 0.015) compared to males; a positive correlation between TSH and aging was found; T4 concentrations were significantly higher (P = 0.003) during summer; and TSH concentrations were lower in GSD managed by the navy (P < 0.0001). BCS was higher (P < 0.0001) in Sirius GSD compared to civilian GSD, and BCS was positively correlated with T4 and negatively correlated with TSH. Conclusions: Reference intervals for T4, fT4 and TSH in GSD were established. The RI for T4 and fT4 was lower compared to other breeds. In addition, sex, age, season, management and BCS demonstrated variable effects on thyroid hormones. Our results can be used as a foundation for improving management and further research of GSD. (© 2021. The Author(s).) |
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| معلومات مُعتمدة: | N2019-0014 Agria & Svenska Kennelklubben Forskningsfond; 117728 Dansk Kennel Klub; 113758 Beckett-Fonden (DK) |
| فهرسة مساهمة: | Keywords: Body condition score; Management; Reference interval; Season; Sled dogs; Thyroid hormones |
| المشرفين على المادة: | 9002-71-5 (Thyrotropin) Q51BO43MG4 (Thyroxine) |
| تواريخ الأحداث: | Date Created: 20211130 Date Completed: 20211203 Latest Revision: 20230921 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8630915 |
| DOI: | 10.1186/s13028-021-00617-8 |
| PMID: | 34844628 |
| قاعدة البيانات: | MEDLINE |
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