دورية أكاديمية
أعرض في EDS

Efficacy of a cultured conditioned medium of exfoliated deciduous dental pulp stem cells in erectile dysfunction patients.

التفاصيل البيبلوغرافية
العنوان: Efficacy of a cultured conditioned medium of exfoliated deciduous dental pulp stem cells in erectile dysfunction patients.
المؤلفون: Koga S; Ginza Solaria Clinic, Panagy Co., Ltd., Tokyo, Japan.; Department of Urology, Edogawa Hospital, Tokyo, Japan., Horiguchi Y; Department of Urology, Edogawa Hospital, Tokyo, Japan.
المصدر: Journal of cellular and molecular medicine [J Cell Mol Med] 2022 Jan; Vol. 26 (1), pp. 195-201. Date of Electronic Publication: 2021 Nov 29.
نوع المنشور: Clinical Trial; Journal Article
اللغة: English
بيانات الدورية: Publisher: Wiley-Blackwell Country of Publication: England NLM ID: 101083777 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1582-4934 (Electronic) Linking ISSN: 15821838 NLM ISO Abbreviation: J Cell Mol Med Subsets: MEDLINE
أسماء مطبوعة: Publication: Oxford, England : Wiley-Blackwell
Original Publication: Bucharest : "Carol Davila" University Press, 2000-
مواضيع طبية MeSH: Erectile Dysfunction*/drug therapy, Adult ; Aged ; Culture Media, Conditioned/pharmacology ; Dental Pulp ; Endothelial Cells ; Humans ; Male ; Middle Aged ; Penile Erection/physiology ; Pilot Projects ; Stem Cells
مستخلص: Majority of current treatment strategies against erectile dysfunction (ED) has been consisted of only a supportive care to sustain enough erection during a sexual intercourse. In this study, we investigated whether the cultured conditioned medium of human exfoliated deciduous dental pulp stem cells (SHED-CM) had an ability to treat ED through fundamentally repairing the pathological damage of vascular endothelial cells of the corpus cavernosum. An open-label pilot study was performed from April 2016 to October 2020. SHED-CM was injected directly into the corpus cavernosum of penis of 38 ED patients who visited our clinic and fulfilled the inclusion criteria. Efficacy was assessed using the simplified International Index of Erectile Function (IIEF-5) questionnaire. The average age and initial IIEF-5 score of the patients enrolled in this study was 56 (31-79) years old and 13.1 (5-20) points, respectively. Medical history revealed 7 patients with diabetes, 7 patients with hypertension and 1 patient with priapism undergone shunt operation. Of these, 37 patients (97.4%) showed an improvement in IIEF-5 of an average of 19.3 (7-25) points or 64.4 (10-300) % increase after three injections of SHED-CM. Eighteen patients (47.4%) achieved more than 21 points (no ED) in IIEF-5. No adverse events were encountered. This is the first clinical report of ED treatment in the literatures evaluating the efficacy of SHED-CM. Treatment with SHED-CM is expected to repair vascular damages of the corpus cavernosum, which are the main cause of ED, and to be widely spread as a fundamental clinical application for ED.
(© 2021 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd.)
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فهرسة مساهمة: Keywords: International Index of Erectile Function; erectile dysfunction; exfoliated deciduous dental pulp; stem cell-derived growth factor; vascular endothelial cells
المشرفين على المادة: 0 (Culture Media, Conditioned)
تواريخ الأحداث: Date Created: 20211130 Date Completed: 20220331 Latest Revision: 20231105
رمز التحديث: 20231105
مُعرف محوري في PubMed: PMC8742184
DOI: 10.1111/jcmm.17072
PMID: 34845823
قاعدة البيانات: MEDLINE
الوصف
تدمد:1582-4934
DOI:10.1111/jcmm.17072