دورية أكاديمية
أعرض في EDS

Effects of free radicals from doxycycline hyclate and minocycline hydrochloride under blue light irradiation on the deactivation of Staphylococcus aureus, including a methicillin-resistant strain.

التفاصيل البيبلوغرافية
العنوان: Effects of free radicals from doxycycline hyclate and minocycline hydrochloride under blue light irradiation on the deactivation of Staphylococcus aureus, including a methicillin-resistant strain.
المؤلفون: Yuann JP; Department of Biotechnology, Ming Chuan University, Gui Shan 333321, Taiwan., Lee SY; Department of Tourism and Leisure, Hsing Wu University, New Taipei City 244012, Taiwan., He S; Department of Biotechnology, Ming Chuan University, Gui Shan 333321, Taiwan., Wong TW; Department of Dermatology, National Cheng Kung University Hospital, Department of Biochemistry and Molecular Biology, College of Medicine, Center of Applied Nanomedicine, National Cheng Kung University, Tainan 70101, Taiwan., Yang MJ; Tea Research and Extension Station, Yangmei 326011, Taiwan., Cheng CW; Department of Biotechnology, Ming Chuan University, Gui Shan 333321, Taiwan., Huang ST; Department of Science Education and Application, National Taichung University of Education, Taichung 40306, Taiwan; Department of Soil and Environmental Sciences, National Chung Hsing University, Taichung 40200, Taiwan. Electronic address: hstsuen@mail.ntcu.edu.tw., Liang JY; Department of Biotechnology, Ming Chuan University, Gui Shan 333321, Taiwan. Electronic address: liang121@mail.mcu.edu.tw.
المصدر: Journal of photochemistry and photobiology. B, Biology [J Photochem Photobiol B] 2022 Jan; Vol. 226, pp. 112370. Date of Electronic Publication: 2021 Nov 27.
نوع المنشور: Journal Article
اللغة: English
بيانات الدورية: Publisher: Elsevier Sequoia Country of Publication: Switzerland NLM ID: 8804966 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1873-2682 (Electronic) Linking ISSN: 10111344 NLM ISO Abbreviation: J Photochem Photobiol B Subsets: PubMed not MEDLINE
أسماء مطبوعة: Original Publication: Lausanne : Elsevier Sequoia, 1987-
مستخلص: Doxycycline hyclate (DCH) and minocycline hydrochloride (MH) are tetracycline antibiotics and broad-spectrum antimicrobial agents. The changes in DCH and MH under blue light (λ = 462 nm) irradiation in alkaline conditions (BLIA) were investigated. Deactivation caused by superoxide anion radical (O 2 •- ) and deactivation from DCH and MH during photolysis on Staphylococcus aureus (S. aureus), including methicillin-resistant S. aureus (MRSA), were studied. DCH is relatively unstable compared to MH under BLIA. The level of O 2 •- generated from the MH-treated photoreaction is lower than that from DCH photolysis, and the DCH-treated photoreaction is more efficient at inactivating S. aureus and MRSA at the same radiant intensity. DCH subjected to BLIA decreased the viability of S. aureus and MRSA by 3.84 and 5.15 log, respectively. Two photolytic products of DCH (PPDs) were generated under BLIA. The mass spectra of the PPDs featured molecular ions at m/z 460.8 and 458.8. The molecular formulas of the PPDs were C 21 H 22 N 2 O 10 and C 22 H 24 N 2 O 9 , and their exact masses were 462.44 and 460.44 g/mol, respectively. These results bolster the photolytic oxidation that leads to DCH-enhanced deactivation of S. aureus and MRSA. Photochemical treatment of DCH could be applied as a supplement in hygienic processes.
(Copyright © 2021 Elsevier B.V. All rights reserved.)
فهرسة مساهمة: Keywords: Blue light; Doxycycline; MRSA; Minocycline; Staphylococcus aureus
تواريخ الأحداث: Date Created: 20211205 Latest Revision: 20240724
رمز التحديث: 20240725
DOI: 10.1016/j.jphotobiol.2021.112370
PMID: 34864528
قاعدة البيانات: MEDLINE
الوصف
تدمد:1873-2682
DOI:10.1016/j.jphotobiol.2021.112370