دورية أكاديمية
Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system.
| العنوان: | Methylome-wide association study of antidepressant use in Generation Scotland and the Netherlands Twin Register implicates the innate immune system. |
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| المؤلفون: | Barbu MC; Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. mbarbu@ed.ac.uk., Huider F; Faculty of Behavioural and Movement Sciences, Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Campbell A; Centre for Genomic and Experimental Medicine, The Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Amador C; MRC Human Genetics Unit, The Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Adams MJ; Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK., Lynall ME; Department of Psychiatry, University of Cambridge, Cambridge, UK., Howard DM; Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK.; Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK., Walker RM; Centre for Genomic and Experimental Medicine, The Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Morris SW; Centre for Genomic and Experimental Medicine, The Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Van Dongen J; Faculty of Behavioural and Movement Sciences, Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Porteous DJ; Centre for Genomic and Experimental Medicine, The Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Evans KL; Centre for Genomic and Experimental Medicine, The Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK., Bullmore E; Department of Psychiatry, University of Cambridge, Cambridge, UK., Willemsen G; Faculty of Behavioural and Movement Sciences, Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Boomsma DI; Faculty of Behavioural and Movement Sciences, Biological Psychology, Vrije Universiteit Amsterdam, Amsterdam, Netherlands., Whalley HC; Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK., McIntosh AM; Division of Psychiatry, The University of Edinburgh, Royal Edinburgh Hospital, Edinburgh, UK. |
| المصدر: | Molecular psychiatry [Mol Psychiatry] 2022 Mar; Vol. 27 (3), pp. 1647-1657. Date of Electronic Publication: 2021 Dec 08. |
| نوع المنشور: | Journal Article; Meta-Analysis; Twin Study; Research Support, Non-U.S. Gov't |
| اللغة: | English |
| بيانات الدورية: | Publisher: Nature Publishing Group Specialist Journals Country of Publication: England NLM ID: 9607835 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1476-5578 (Electronic) Linking ISSN: 13594184 NLM ISO Abbreviation: Mol Psychiatry Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2000- : Houndmills, Basingstoke, UK : Nature Publishing Group Specialist Journals Original Publication: Houndmills, Hampshire, UK ; New York, NY : Stockton Press, c1996- |
| مواضيع طبية MeSH: | Depressive Disorder, Major*/drug therapy , Depressive Disorder, Major*/genetics , Pregnancy Proteins*/genetics, Antidepressive Agents/therapeutic use ; Epigenome ; Heme-Binding Proteins ; Humans ; Immune System ; Netherlands ; Scotland |
| مستخلص: | Antidepressants are an effective treatment for major depressive disorder (MDD), although individual response is unpredictable and highly variable. Whilst the mode of action of antidepressants is incompletely understood, many medications are associated with changes in DNA methylation in genes that are plausibly linked to their mechanisms. Studies of DNA methylation may therefore reveal the biological processes underpinning the efficacy and side effects of antidepressants. We performed a methylome-wide association study (MWAS) of self-reported antidepressant use accounting for lifestyle factors and MDD in Generation Scotland (GS:SFHS, N = 6428, EPIC array) and the Netherlands Twin Register (NTR, N = 2449, 450 K array) and ran a meta-analysis of antidepressant use across these two cohorts. We found ten CpG sites significantly associated with self-reported antidepressant use in GS:SFHS, with the top CpG located within a gene previously associated with mental health disorders, ATP6V1B2 (β = -0.055, p (© 2021. The Author(s).) |
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| معلومات مُعتمدة: | 220857/Z/20/Z United Kingdom WT_ Wellcome Trust; 104036/Z/14/Z United Kingdom WT_ Wellcome Trust; MR/W014386/1 United Kingdom MRC_ Medical Research Council; CZD/16/6 United Kingdom CSO_ Chief Scientist Office; MR/S006257/1 United Kingdom MRC_ Medical Research Council; 213674/Z/18/Z United Kingdom WT_ Wellcome Trust; MC_G0802534 United Kingdom MRC_ Medical Research Council; MC_UU_00007/10 United Kingdom MRC_ Medical Research Council; United Kingdom WT_ Wellcome Trust |
| المشرفين على المادة: | 0 (Antidepressive Agents) 0 (HEBP2 protein, human) 0 (Heme-Binding Proteins) 0 (Pregnancy Proteins) |
| تواريخ الأحداث: | Date Created: 20211209 Date Completed: 20220517 Latest Revision: 20240214 |
| رمز التحديث: | 20240214 |
| مُعرف محوري في PubMed: | PMC9095457 |
| DOI: | 10.1038/s41380-021-01412-7 |
| PMID: | 34880450 |
| قاعدة البيانات: | MEDLINE |
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| DOI: | 10.1038/s41380-021-01412-7 |