دورية أكاديمية
Correlation between the expression of matrix metalloproteinase 9 and the expression of tissue inhibitor of metalloproteinase-1 of uterosacral ligament in uterine prolapse.
| العنوان: | Correlation between the expression of matrix metalloproteinase 9 and the expression of tissue inhibitor of metalloproteinase-1 of uterosacral ligament in uterine prolapse. |
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| المؤلفون: | Santoso DPJ; Department of Obstetrics and Gynaecology, Dr. Hasan Sadikin Hospital Bandung, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia., Purwara BH; Department of Obstetrics and Gynaecology, Dr. Hasan Sadikin Hospital Bandung, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia., Achmad ED; Department of Obstetrics and Gynaecology, Dr. Hasan Sadikin Hospital Bandung, Faculty of Medicine, Padjadjaran University, Bandung, Indonesia. |
| المصدر: | Obstetrics & gynecology science [Obstet Gynecol Sci] 2022 Jan; Vol. 65 (1), pp. 46-51. Date of Electronic Publication: 2021 Dec 14. |
| نوع المنشور: | Journal Article |
| اللغة: | English |
| بيانات الدورية: | Publisher: Korean Society of Obstetrics and Gynecology Country of Publication: Korea (South) NLM ID: 101602614 Publication Model: Print-Electronic Cited Medium: Print ISSN: 2287-8572 (Print) Linking ISSN: 22878572 NLM ISO Abbreviation: Obstet Gynecol Sci Subsets: PubMed not MEDLINE |
| أسماء مطبوعة: | Original Publication: Seoul : Korean Society of Obstetrics and Gynecology |
| مستخلص: | Objective: This study aimed to analyze the correlation between the immunoexpression of matrix metalloproteinase 9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TiMP1) in the uterosacral ligaments in patients with uterine prolapse. Methods: This analytic-correlative cross-sectional study included 32 patients who were admitted at the Hasan Sadikin General Hospital from July to December 2013. Sixteen of the patients had uterine prolapse, while the rest did not. The patients underwent total hysterectomy, radical hysterectomy, or staging laparotomy. MMP-9 and TiMP1 expression in the uterosacral ligaments was measured via immunohistochemical staining. The median expression per field of view was calculated using a histoscore. Results: MMP-9 expression in patients with uterine prolapse was found to be higher than that in the control group. Meanwhile, TiMP1 expression showed no significant difference between the groups. Spearman's analysis showed a moderate correlation between the expression of MMP-9 and uterine prolapse incidence (P=0.02), with a correlation coefficient of 0.574. Conclusion: There is a moderate correlation between MMP-9 expression and the incidence of uterine prolapse. It can be considered one of the primary etiologies of uterine prolapse. |
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| فهرسة مساهمة: | Keywords: Correlation; Matrix metalloproteinase 9; TiMP1; Uterine prolapse; Uterosacral ligament |
| تواريخ الأحداث: | Date Created: 20211213 Latest Revision: 20220202 |
| رمز التحديث: | 20231215 |
| مُعرف محوري في PubMed: | PMC8784936 |
| DOI: | 10.5468/ogs.21156 |
| PMID: | 34902892 |
| قاعدة البيانات: | MEDLINE |
Full Text Finder | تدمد: | 2287-8572 |
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| DOI: | 10.5468/ogs.21156 |