دورية أكاديمية
أعرض في EDS

Competitive dynamics underlie cognitive improvements during sleep.

التفاصيل البيبلوغرافية
العنوان: Competitive dynamics underlie cognitive improvements during sleep.
المؤلفون: Chen PC; Department of Cognitive Sciences, University of California, Irvine, CA 92697.; Department of Statistics, University of California, Irvine, CA 92697., Niknazar H; Department of Cognitive Sciences, University of California, Irvine, CA 92697., Alaynick WA; ScholarNexus LLC, San Diego, CA 92122., Whitehurst LN; Department of Psychology, University of Kentucky, Lexington, KY 40506., Mednick SC; Department of Cognitive Sciences, University of California, Irvine, CA 92697; mednicks@uci.edu.
المصدر: Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 Dec 21; Vol. 118 (51).
نوع المنشور: Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.
اللغة: English
بيانات الدورية: Publisher: National Academy of Sciences Country of Publication: United States NLM ID: 7505876 Publication Model: Print Cited Medium: Internet ISSN: 1091-6490 (Electronic) Linking ISSN: 00278424 NLM ISO Abbreviation: Proc Natl Acad Sci U S A Subsets: MEDLINE
أسماء مطبوعة: Original Publication: Washington, DC : National Academy of Sciences
مواضيع طبية MeSH: Memory, Long-Term/*physiology , Memory, Short-Term/*physiology , Sleep/*physiology, Adult ; Autonomic Nervous System/drug effects ; Autonomic Nervous System/physiology ; Cerebral Cortex/drug effects ; Cerebral Cortex/physiology ; Female ; Hippocampus/drug effects ; Hippocampus/physiology ; Humans ; Male ; Memory Consolidation/drug effects ; Memory Consolidation/physiology ; Memory, Long-Term/drug effects ; Memory, Short-Term/drug effects ; Models, Neurological ; Neural Pathways ; Sleep/drug effects ; Sleep Stages/drug effects ; Sleep Stages/physiology ; Zolpidem/pharmacology
مستخلص: We provide evidence that human sleep is a competitive arena in which cognitive domains vie for limited resources. Using pharmacology and effective connectivity analysis, we demonstrate that long-term memory and working memory are served by distinct offline neural mechanisms that are mutually antagonistic. Specifically, we administered zolpidem to increase central sigma activity and demonstrated targeted suppression of autonomic vagal activity. With effective connectivity, we determined the central activity has greater causal influence over autonomic activity, and the magnitude of this influence during sleep produced a behavioral trade-off between offline long-term and working memory processing. These findings suggest a sleep switch mechanism that toggles between central sigma-dependent long-term memory and autonomic vagal-dependent working memory processing.
Competing Interests: The authors declare no competing interest.
(Copyright © 2021 the Author(s). Published by PNAS.)
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معلومات مُعتمدة: R01 AG046646 United States AG NIA NIH HHS
فهرسة مساهمة: Keywords: long-term memory; sleep; spindle activity; vagal activity; working memory
المشرفين على المادة: 7K383OQI23 (Zolpidem)
تواريخ الأحداث: Date Created: 20211214 Date Completed: 20220113 Latest Revision: 20220123
رمز التحديث: 20221213
مُعرف محوري في PubMed: PMC8713802
DOI: 10.1073/pnas.2109339118
PMID: 34903651
قاعدة البيانات: MEDLINE
الوصف
تدمد:1091-6490
DOI:10.1073/pnas.2109339118