دورية أكاديمية
A review on garcinia kola heckel: traditional uses, phytochemistry, pharmacological activities, and toxicology.
| العنوان: | A review on garcinia kola heckel: traditional uses, phytochemistry, pharmacological activities, and toxicology. |
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| المؤلفون: | Emmanuel O; Department of Biochemistry, Abia State University, Uturu, Nigeria., Uche ME; Department of Biochemistry, Abia State University, Uturu, Nigeria., Dike ED; Department of Biochemistry, Abia State University, Uturu, Nigeria., Etumnu LR; Department of Biochemistry, Abia State University, Uturu, Nigeria., Ugbogu OC; Department of Microbiology, Abia State University, Uturu, Nigeria., Ugbogu EA; Department of Biochemistry, Abia State University, Uturu, Nigeria. |
| المصدر: | Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2022 Mar; Vol. 27 (2), pp. 101-117. Date of Electronic Publication: 2021 Dec 31. |
| نوع المنشور: | Journal Article; Review |
| اللغة: | English |
| بيانات الدورية: | Publisher: Tayor & Francis Country of Publication: England NLM ID: 9606000 Publication Model: Print-Electronic Cited Medium: Internet ISSN: 1366-5804 (Electronic) Linking ISSN: 1354750X NLM ISO Abbreviation: Biomarkers Subsets: MEDLINE |
| أسماء مطبوعة: | Publication: 2015- : Abingdon, Oxford : Tayor & Francis Original Publication: London : Taylor & Francis, c1996- |
| مواضيع طبية MeSH: | Garcinia kola*/chemistry, Antioxidants ; Humans ; Phytochemicals/pharmacology ; Plant Extracts/chemistry ; Plant Extracts/pharmacology |
| مستخلص: | Purpose: Garcinia kola is a medicinal plant commonly known as bitter kola. It is utilised in ethnomedicine for the treatment of diarrhoea, bronchitis, bacterial infection, cough, hepatitis, gonorrhoea, laryngitis, food poison, liver and gastric diseases. Objective: This study reviewed the phytochemistry, pharmacological activities, and ethnomedicinal potentials of G. kola . Materials and Methods: An extensive review was performed using electronic literature collated from ScienceDirect, Springer, Wiley, and PubMed databases. Results: Phytochemical analysis revealed the isolation of several chemical compounds including 9-octadecenoic acid, linoleic acid, 14-methylpentadecanoic acid, 1-butanol, hexadecanamide, I-4',II-4',I-5,II-5,I-7,II-7-hexahydroxy-I-3,II-8-biflavanone, lanost-7-en-3-one, kolaflavanone (8E)-4-geranyl-3,5-dihydroxybenzophenone, glutinol, Garcinia biflavonoid (GB-2a-II-4'-OMe), 9,19-cyclolanost-24-en-3-ol, 24-methylene, tirucallol, lupeol, β-amyrin, obtusifoliol and Kolaviron. Diverse pharmacological in-vivo and in vitro investigations revealed that G. kola has anti-inflammatory, antimalarial, hepatoprotective, cardioprotective, anti-asthmatic, neuroprotective, antioxidant, and antidiabetic activities. Conclusion: The present study revealed that G. kola has preventive and therapeutic potentials against various diseases in both in vivo and in vitro studies and therefore can be utilised as a raw material in the pharmaceutical industries for the development of therapeutic products. However, there is a need for clinical trial experiments to validate and provide accurate and substantial information on the required safe dosage and efficacy for the treatment of several diseases. |
| فهرسة مساهمة: | Keywords: Garcinia kola; pharmacological; phytochemistry; toxicology |
| المشرفين على المادة: | 0 (Antioxidants) 0 (Phytochemicals) 0 (Plant Extracts) |
| تواريخ الأحداث: | Date Created: 20211214 Date Completed: 20220404 Latest Revision: 20220430 |
| رمز التحديث: | 20240829 |
| DOI: | 10.1080/1354750X.2021.2016974 |
| PMID: | 34904497 |
| قاعدة البيانات: | MEDLINE |
PDF full text from Publisher | تدمد: | 1366-5804 |
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| DOI: | 10.1080/1354750X.2021.2016974 |